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Protein

NAD/NADP-dependent betaine aldehyde dehydrogenase

Gene

betB

Organism
Burkholderia pseudomallei (strain 1106a)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid.UniRule annotation

Catalytic activityi

Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

K+UniRule annotationNote: Binds 2 potassium ions per subunit.UniRule annotation

Pathwayi: betaine biosynthesis via choline pathway

This protein is involved in step 1 of the subpathway that synthesizes betaine from betaine aldehyde.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. NAD/NADP-dependent betaine aldehyde dehydrogenase (betB)
This subpathway is part of the pathway betaine biosynthesis via choline pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes betaine from betaine aldehyde, the pathway betaine biosynthesis via choline pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi26Potassium 1UniRule annotation1
Metal bindingi93Potassium 1UniRule annotation1
Active sitei162Charge relay systemUniRule annotation1
Metal bindingi180Potassium 1; via carbonyl oxygenUniRule annotation1
Binding sitei209NAD/NADP; via amide nitrogenUniRule annotation1
Metal bindingi245Potassium 2; via carbonyl oxygenUniRule annotation1
Sitei247Seems to be a necessary countercharge to the potassium cationsUniRule annotation1
Active sitei251Proton acceptorUniRule annotation1
Binding sitei285NAD/NADPUniRule annotation1
Binding sitei386NAD/NADPUniRule annotation1
Metal bindingi456Potassium 2; via carbonyl oxygenUniRule annotation1
Metal bindingi459Potassium 2; via carbonyl oxygenUniRule annotation1
Active sitei463Charge relay systemUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi150 – 153NAD/NADPUniRule annotation4
Nucleotide bindingi176 – 179NAD/NADPUniRule annotation4
Nucleotide bindingi228 – 233NAD/NADPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, NADP, Potassium

Enzyme and pathway databases

UniPathwayiUPA00529; UER00386.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD/NADP-dependent betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADHUniRule annotation
Gene namesi
Name:betBUniRule annotation
Ordered Locus Names:BURPS1106A_A1836
OrganismiBurkholderia pseudomallei (strain 1106a)
Taxonomic identifieri357348 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
Proteomesi
  • UP000006738 Componenti: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000470371 – 489NAD/NADP-dependent betaine aldehyde dehydrogenaseAdd BLAST489

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei285Cysteine sulfenic acid (-SOH)UniRule annotation1

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Dimer of dimers.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA3P6B0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000271505.
KOiK00130.
OMAiTKSVYVG.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPiMF_00804. BADH. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01804. BADH. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3P6B0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVYGLQRLY IAGAHADATS GKTFDTFDPA TGELLARVQQ ASADDVDRAV
60 70 80 90 100
ASAREGQREW AAMTAMQRSR ILRRAVELLR ERNDALAELE MRDTGKPIAE
110 120 130 140 150
TRAVDIVTGA DVIEYYAGLA TAIEGLQVPL RPESFVYTRR EPLGVCAGIG
160 170 180 190 200
AWNYPIQIAC WKSAPALAAG NAMIFKPSEV TPLSALKLAE IYTEAGVPAG
210 220 230 240 250
VFNVVQGDGS VGALLSAHPG IAKVSFTGGV ETGKKVMSLA GASSLKEVTM
260 270 280 290 300
ELGGKSPLIV FDDADLDRAA DIAVTANFFS AGQVCTNGTR VFVQQAVKDA
310 320 330 340 350
FVERVLARVA RIRVGKPSDS DTNFGPLASA AQLDKVLGYI DSGKAEGAKL
360 370 380 390 400
LAGGARLVND HFASGQYVAP TVFGDCRDDM RIVREEIFGP VMSILSFETE
410 420 430 440 450
DEAIARANAT DYGLAAGVVT ENLSRAHRAI HRLEAGICWI NTWGESPAEM
460 470 480
PVGGYKQSGV GRENGITTLE HYTRIKSVQV ELGRYQPVF
Length:489
Mass (Da):52,191
Last modified:April 3, 2007 - v1
Checksum:iB53067B29C8665F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000573 Genomic DNA. Translation: ABN93040.1.
RefSeqiWP_004528662.1. NC_009078.1.

Genome annotation databases

EnsemblBacteriaiABN93040; ABN93040; BURPS1106A_A1836.
KEGGibpl:BURPS1106A_A1836.
PATRICi19229703. VBIBurPse14980_5468.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000573 Genomic DNA. Translation: ABN93040.1.
RefSeqiWP_004528662.1. NC_009078.1.

3D structure databases

ProteinModelPortaliA3P6B0.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABN93040; ABN93040; BURPS1106A_A1836.
KEGGibpl:BURPS1106A_A1836.
PATRICi19229703. VBIBurPse14980_5468.

Phylogenomic databases

HOGENOMiHOG000271505.
KOiK00130.
OMAiTKSVYVG.

Enzyme and pathway databases

UniPathwayiUPA00529; UER00386.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPiMF_00804. BADH. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01804. BADH. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBETB_BURP0
AccessioniPrimary (citable) accession number: A3P6B0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: November 2, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.