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A3P0U7

- GCSP_BURP0

UniProt

A3P0U7 - GCSP_BURP0

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, BURPS1106A_4000
Organism
Burkholderia pseudomallei (strain 1106a)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciBPSE357348:GHVF-3999-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:BURPS1106A_4000
OrganismiBurkholderia pseudomallei (strain 1106a)
Taxonomic identifieri357348 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
ProteomesiUP000006738: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 970970Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_1000045574Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei723 – 7231N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi357348.BURPS1106A_4000.

Structurei

3D structure databases

ProteinModelPortaliA3P0U7.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

A3P0U7-1 [UniParc]FASTAAdd to Basket

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MKLEHPDRLM NRTPLSLAAL ETHDAFAERH IGPDAASQQA MLDTLGFATR    50
AALIDAVIPA SIRRAETLPL GPFAQPKSEA EALAALRALA DKNQVFRSYI 100
GQGYYDTHTP AVILRNVLEN PAWYTAYTPY QPEISQGRLE ALLNFQQMVA 150
DLTGLEISNA SLLDEATAAA EAMTLLQRVG KPQSNVFYVA DDVLPQTLEV 200
IKTRAKPIGI EVKSGPAADA AAANAFGVLL QYPGANGDVR DYRALADAIH 250
AAGGHVVVAA DILALTVLMP PGEWGADVAV GNTQRFGVPM GFGGPHAAYM 300
AVRDEFKRQM PGRLVGVTVD AQGKPALRLA LQTREQHIRR EKATSNVCTA 350
QALLAIMASM YAVYHGPRGL KTIALRVNRI AALLAAGIRH LGYATVNDTF 400
FDTLTIDTGA RTAQLHAFAQ AKRINLRRAG DTRVGVSVDE TTTRADLADL 450
LTIFAQAAGA TAPDIDALDA GLLPAPALPP SLERTSAYLT HHVFNRHHSE 500
TEMLRYLRSL SDKDLALDRS MIPLGSCTMK LNATSEMLPV TWPEFGRIHP 550
FAPAEQTVGY REMIDQLEQM LVAATGYAAV SLQPNAGSQG EYAGLLIIHA 600
YHESRGESHR DVCLIPASAH GTNPASAHMA GMKVVVVACD AQGNVDIADL 650
KAKADAHSHD LAAIMITYPS THGVFEQNVR EICEIVHAHG GQVYVDGANM 700
NAMVGLTAPG QFGGDVSHLN LHKTFCIPHG GGGPGVGPHL AKFLPNQRST 750
GYARGEDGIG AVSAAPYGSA SILPISWMYI AMMGAKNLTA ATETAILNAN 800
YIAKRLAPHY PVLYSGPGGL VAHECILDLR PIKDSSGITV DDVAKRLMDY 850
GFHAPTMSFP VPGTLMVEPT ESESQEELDR FIAAMIAIRD EIRAVEEGRA 900
DREDNPLRHA PHTAAVVTAN EWPHAYSREQ AAFPVASLVA NKYWPPVGRA 950
DNAYGDRNLF CSCVPVSDYA 970
Length:970
Mass (Da):104,036
Last modified:April 3, 2007 - v1
Checksum:i737CC68C04B9E47E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000572 Genomic DNA. Translation: ABN89009.1.
RefSeqiWP_004535539.1. NC_009076.1.
YP_001068218.1. NC_009076.1.

Genome annotation databases

EnsemblBacteriaiABN89009; ABN89009; BURPS1106A_4000.
GeneIDi4900284.
KEGGibpl:BURPS1106A_4000.
PATRICi19226263. VBIBurPse14980_3757.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000572 Genomic DNA. Translation: ABN89009.1 .
RefSeqi WP_004535539.1. NC_009076.1.
YP_001068218.1. NC_009076.1.

3D structure databases

ProteinModelPortali A3P0U7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 357348.BURPS1106A_4000.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABN89009 ; ABN89009 ; BURPS1106A_4000 .
GeneIDi 4900284.
KEGGi bpl:BURPS1106A_4000.
PATRICi 19226263. VBIBurPse14980_3757.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci BPSE357348:GHVF-3999-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. DeShazer D., Woods D.E., Nierman W.C.
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1106a.

Entry informationi

Entry nameiGCSP_BURP0
AccessioniPrimary (citable) accession number: A3P0U7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: September 3, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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