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A3P0U7 (GCSP_BURP0) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:BURPS1106A_4000
OrganismBurkholderia pseudomallei (strain 1106a) [Complete proteome] [HAMAP]
Taxonomic identifier357348 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group

Protein attributes

Sequence length970 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 970970Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000045574

Amino acid modifications

Modified residue7231N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
A3P0U7 [UniParc].

Last modified April 3, 2007. Version 1.
Checksum: 737CC68C04B9E47E

FASTA970104,036
        10         20         30         40         50         60 
MKLEHPDRLM NRTPLSLAAL ETHDAFAERH IGPDAASQQA MLDTLGFATR AALIDAVIPA 

        70         80         90        100        110        120 
SIRRAETLPL GPFAQPKSEA EALAALRALA DKNQVFRSYI GQGYYDTHTP AVILRNVLEN 

       130        140        150        160        170        180 
PAWYTAYTPY QPEISQGRLE ALLNFQQMVA DLTGLEISNA SLLDEATAAA EAMTLLQRVG 

       190        200        210        220        230        240 
KPQSNVFYVA DDVLPQTLEV IKTRAKPIGI EVKSGPAADA AAANAFGVLL QYPGANGDVR 

       250        260        270        280        290        300 
DYRALADAIH AAGGHVVVAA DILALTVLMP PGEWGADVAV GNTQRFGVPM GFGGPHAAYM 

       310        320        330        340        350        360 
AVRDEFKRQM PGRLVGVTVD AQGKPALRLA LQTREQHIRR EKATSNVCTA QALLAIMASM 

       370        380        390        400        410        420 
YAVYHGPRGL KTIALRVNRI AALLAAGIRH LGYATVNDTF FDTLTIDTGA RTAQLHAFAQ 

       430        440        450        460        470        480 
AKRINLRRAG DTRVGVSVDE TTTRADLADL LTIFAQAAGA TAPDIDALDA GLLPAPALPP 

       490        500        510        520        530        540 
SLERTSAYLT HHVFNRHHSE TEMLRYLRSL SDKDLALDRS MIPLGSCTMK LNATSEMLPV 

       550        560        570        580        590        600 
TWPEFGRIHP FAPAEQTVGY REMIDQLEQM LVAATGYAAV SLQPNAGSQG EYAGLLIIHA 

       610        620        630        640        650        660 
YHESRGESHR DVCLIPASAH GTNPASAHMA GMKVVVVACD AQGNVDIADL KAKADAHSHD 

       670        680        690        700        710        720 
LAAIMITYPS THGVFEQNVR EICEIVHAHG GQVYVDGANM NAMVGLTAPG QFGGDVSHLN 

       730        740        750        760        770        780 
LHKTFCIPHG GGGPGVGPHL AKFLPNQRST GYARGEDGIG AVSAAPYGSA SILPISWMYI 

       790        800        810        820        830        840 
AMMGAKNLTA ATETAILNAN YIAKRLAPHY PVLYSGPGGL VAHECILDLR PIKDSSGITV 

       850        860        870        880        890        900 
DDVAKRLMDY GFHAPTMSFP VPGTLMVEPT ESESQEELDR FIAAMIAIRD EIRAVEEGRA 

       910        920        930        940        950        960 
DREDNPLRHA PHTAAVVTAN EWPHAYSREQ AAFPVASLVA NKYWPPVGRA DNAYGDRNLF 

       970 
CSCVPVSDYA 

« Hide

References

[1]DeShazer D., Woods D.E., Nierman W.C.
Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1106a.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000572 Genomic DNA. Translation: ABN89009.1.
RefSeqYP_001068218.1. NC_009076.1.

3D structure databases

ProteinModelPortalA3P0U7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING357348.BURPS1106A_4000.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABN89009; ABN89009; BURPS1106A_4000.
GeneID4900284.
KEGGbpl:BURPS1106A_4000.
PATRIC19226263. VBIBurPse14980_3757.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAFDSRPYS.
OrthoDBEOG6HMXDX.

Enzyme and pathway databases

BioCycBPSE357348:GHVF-3999-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_BURP0
AccessionPrimary (citable) accession number: A3P0U7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: May 14, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families