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A3P026 (HIS3_BURP0) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoribosyl-AMP cyclohydrolase

Short name=PRA-CH
EC=3.5.4.19
Gene names
Name:hisI
Ordered Locus Names:BURPS1106A_3717
OrganismBurkholderia pseudomallei (strain 1106a) [Complete proteome] [HAMAP]
Taxonomic identifier357348 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group

Protein attributes

Sequence length137 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

1-(5-phospho-beta-D-ribosyl)-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide. HAMAP-Rule MF_01021

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9. HAMAP-Rule MF_01021

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01021.

Sequence similarities

Belongs to the PRA-CH family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Histidine biosynthesis
   Cellular componentCytoplasm
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processhistidine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionphosphoribosyl-AMP cyclohydrolase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 137137Phosphoribosyl-AMP cyclohydrolase HAMAP-Rule MF_01021
PRO_1000063397

Sequences

Sequence LengthMass (Da)Tools
A3P026 [UniParc].

Last modified April 3, 2007. Version 1.
Checksum: D792C45902D6F457

FASTA13715,699
        10         20         30         40         50         60 
MNAEAKPGDW LGKVRWDANG LVPVIAQDAA TNDVLMFAWM NRDALAKTIE LKRAVYYSRS 

        70         80         90        100        110        120 
RQRLWFKGEE SGHVQHVHEV RLDCDEDVVL LKVEQVEGIA CHTGRRSCFF QKFEGTVDDG 

       130 
EWVAVDPVLK DPEHIYK 

« Hide

References

[1]DeShazer D., Woods D.E., Nierman W.C.
Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1106a.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000572 Genomic DNA. Translation: ABN91984.1.
RefSeqYP_001067947.1. NC_009076.1.

3D structure databases

ProteinModelPortalA3P026.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING357348.BURPS1106A_3717.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABN91984; ABN91984; BURPS1106A_3717.
GeneID4902182.
KEGGbpl:BURPS1106A_3717.
PATRIC19225737. VBIBurPse14980_3505.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0139.
HOGENOMHOG000277504.
KOK01496.
OMAHEPGIAC.
OrthoDBEOG6PGKB6.

Enzyme and pathway databases

BioCycBPSE357348:GHVF-3718-MONOMER.
UniPathwayUPA00031; UER00008.

Family and domain databases

HAMAPMF_01021. HisI.
InterProIPR026660. PRA-CH.
IPR002496. PRib_AMP_CycHydrolase_dom.
[Graphical view]
PfamPF01502. PRA-CH. 1 hit.
[Graphical view]
ProDomPD002610. PRA_CycHdrlase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Entry information

Entry nameHIS3_BURP0
AccessionPrimary (citable) accession number: A3P026
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: April 3, 2007
Last modified: May 14, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways