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A3P026

- HIS3_BURP0

UniProt

A3P026 - HIS3_BURP0

Protein

Phosphoribosyl-AMP cyclohydrolase

Gene

hisI

Organism
Burkholderia pseudomallei (strain 1106a)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.UniRule annotation

    Catalytic activityi

    1-(5-phospho-beta-D-ribosyl)-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide.UniRule annotation

    Cofactori

    Binds 1 magnesium ion per subunit.UniRule annotation
    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi83 – 831MagnesiumUniRule annotation
    Metal bindingi84 – 841Zinc; shared with dimeric partnerUniRule annotation
    Metal bindingi85 – 851MagnesiumUniRule annotation
    Metal bindingi87 – 871MagnesiumUniRule annotation
    Metal bindingi101 – 1011Zinc; shared with dimeric partnerUniRule annotation
    Metal bindingi108 – 1081Zinc; shared with dimeric partnerUniRule annotation

    GO - Molecular functioni

    1. phosphoribosyl-AMP cyclohydrolase activity Source: UniProtKB-EC

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Magnesium, Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciBPSE357348:GHVF-3718-MONOMER.
    UniPathwayiUPA00031; UER00008.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosyl-AMP cyclohydrolaseUniRule annotation (EC:3.5.4.19UniRule annotation)
    Short name:
    PRA-CHUniRule annotation
    Gene namesi
    Name:hisIUniRule annotation
    Ordered Locus Names:BURPS1106A_3717
    OrganismiBurkholderia pseudomallei (strain 1106a)
    Taxonomic identifieri357348 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
    ProteomesiUP000006738: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 137137Phosphoribosyl-AMP cyclohydrolasePRO_1000063397Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi357348.BURPS1106A_3717.

    Structurei

    3D structure databases

    ProteinModelPortaliA3P026.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PRA-CH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0139.
    HOGENOMiHOG000277504.
    KOiK01496.
    OMAiHEPGIAC.
    OrthoDBiEOG6PGKB6.

    Family and domain databases

    HAMAPiMF_01021. HisI.
    InterProiIPR026660. PRA-CH.
    IPR002496. PRib_AMP_CycHydrolase_dom.
    [Graphical view]
    PfamiPF01502. PRA-CH. 1 hit.
    [Graphical view]
    ProDomiPD002610. PRA_CycHdrlase. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    A3P026-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNAEAKPGDW LGKVRWDANG LVPVIAQDAA TNDVLMFAWM NRDALAKTIE    50
    LKRAVYYSRS RQRLWFKGEE SGHVQHVHEV RLDCDEDVVL LKVEQVEGIA 100
    CHTGRRSCFF QKFEGTVDDG EWVAVDPVLK DPEHIYK 137
    Length:137
    Mass (Da):15,699
    Last modified:April 3, 2007 - v1
    Checksum:iD792C45902D6F457
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000572 Genomic DNA. Translation: ABN91984.1.
    RefSeqiYP_001067947.1. NC_009076.1.

    Genome annotation databases

    EnsemblBacteriaiABN91984; ABN91984; BURPS1106A_3717.
    GeneIDi4902182.
    KEGGibpl:BURPS1106A_3717.
    PATRICi19225737. VBIBurPse14980_3505.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000572 Genomic DNA. Translation: ABN91984.1 .
    RefSeqi YP_001067947.1. NC_009076.1.

    3D structure databases

    ProteinModelPortali A3P026.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 357348.BURPS1106A_3717.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABN91984 ; ABN91984 ; BURPS1106A_3717 .
    GeneIDi 4902182.
    KEGGi bpl:BURPS1106A_3717.
    PATRICi 19225737. VBIBurPse14980_3505.

    Phylogenomic databases

    eggNOGi COG0139.
    HOGENOMi HOG000277504.
    KOi K01496.
    OMAi HEPGIAC.
    OrthoDBi EOG6PGKB6.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00008 .
    BioCyci BPSE357348:GHVF-3718-MONOMER.

    Family and domain databases

    HAMAPi MF_01021. HisI.
    InterProi IPR026660. PRA-CH.
    IPR002496. PRib_AMP_CycHydrolase_dom.
    [Graphical view ]
    Pfami PF01502. PRA-CH. 1 hit.
    [Graphical view ]
    ProDomi PD002610. PRA_CycHdrlase. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. DeShazer D., Woods D.E., Nierman W.C.
      Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1106a.

    Entry informationi

    Entry nameiHIS3_BURP0
    AccessioniPrimary (citable) accession number: A3P026
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3