A3P026 (HIS3_BURP0) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosyl-AMP cyclohydrolase
Short name=PRA-CH
EC=3.5.4.19

Gene names

Name:	hisI
Ordered Locus Names:	BURPS1106A_3717

Organism

Burkholderia pseudomallei (strain 1106a) [Complete proteome] [HAMAP]

Taxonomic identifier

357348 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group › Burkholderia pseudomallei

Protein attributes

Sequence length	137 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(5-phosphoribosyl)-AMP + H2O = 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide. HAMAP-Rule MF_01021
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9. HAMAP-Rule MF_01021
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the PRA-CH family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	phosphoribosyl-AMP cyclohydrolase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 137	137	Phosphoribosyl-AMP cyclohydrolase HAMAP-Rule MF_01021		PRO_1000063397

Sequences

	Sequence		Length	Mass (Da)
	A3P026 [UniParc]. Last modified April 3, 2007. Version 1. Checksum: D792C45902D6F457	FASTA	137	15,699
	10 20 30 40 50 60 MNAEAKPGDW LGKVRWDANG LVPVIAQDAA TNDVLMFAWM NRDALAKTIE LKRAVYYSRS 70 80 90 100 110 120 RQRLWFKGEE SGHVQHVHEV RLDCDEDVVL LKVEQVEGIA CHTGRRSCFF QKFEGTVDDG 130 EWVAVDPVLK DPEHIYK

References

[1]	DeShazer D., Woods D.E., Nierman W.C. Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1106a.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000572 Genomic DNA. Translation: ABN91984.1.
RefSeq	YP_001067947.1. NC_009076.1.
3D structure databases
ProteinModelPortal	A3P026.
ModBase	Search...
Protein-protein interaction databases
STRING	357348.BURPS1106A_3717.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABN91984; ABN91984; BURPS1106A_3717.
GeneID	4902182.
KEGG	bpl:BURPS1106A_3717.
PATRIC	19225737. VBIBurPse14980_3505.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0139.
HOGENOM	HOG000277504.
KO	K01496.
OMA	GACHVGY.
ProtClustDB	PRK00051.
Enzyme and pathway databases
BioCyc	BPSE357348:GHVF-6714-MONOMER.
UniPathway	UPA00031; UER00008.
Family and domain databases
HAMAP	MF_01021. HisI.
InterPro	IPR026660. PRA-CH. IPR002496. PRib_AMP_CycHydrolase_dom. [Graphical view]
Pfam	PF01502. PRA-CH. 1 hit. [Graphical view]
ProDom	PD002610. PRA_CycHdrlase. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

HIS3_BURP0

Accession

Primary (citable) accession number: A3P026

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	April 3, 2007
Last modified:	May 1, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program