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A3NZ83

- A3NZ83_BURP0

UniProt

A3NZ83 - A3NZ83_BURP0

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Protein

Dihydroorotase

Gene

pyrC

Organism
Burkholderia pseudomallei (strain 1106a)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate.UniRule annotationSAAS annotation

Cofactori

Note: Binds 2 zinc ions per subunit.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi18 – 181Zinc 1; via tele nitrogenUniRule annotation
Metal bindingi20 – 201Zinc 1; via tele nitrogenUniRule annotation
Metal bindingi104 – 1041Zinc 1; via carbamate groupUniRule annotation
Metal bindingi104 – 1041Zinc 2; via carbamate groupUniRule annotation
Metal bindingi142 – 1421Zinc 2; via pros nitrogenUniRule annotation
Metal bindingi180 – 1801Zinc 2; via tele nitrogenUniRule annotation
Metal bindingi256 – 2561Zinc 1UniRule annotation

GO - Molecular functioni

  1. dihydroorotase activity Source: UniProtKB-HAMAP
  2. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  2. pyrimidine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Biological processi

Pyrimidine biosynthesisUniRule annotation

Keywords - Ligandi

Metal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

BioCyciBPSE357348:GHVF-3417-MONOMER.
UniPathwayiUPA00070; UER00117.

Names & Taxonomyi

Protein namesi
Recommended name:
DihydroorotaseUniRule annotationSAAS annotation (EC:3.5.2.3UniRule annotationSAAS annotation)
Short name:
DHOaseUniRule annotation
Gene namesi
Name:pyrCUniRule annotationImported
Ordered Locus Names:BURPS1106A_3417Imported
OrganismiBurkholderia pseudomallei (strain 1106a)Imported
Taxonomic identifieri357348 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
ProteomesiUP000006738: Chromosome I

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei104 – 1041N6-carboxylysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi357348.BURPS1106A_3417.

Structurei

3D structure databases

ProteinModelPortaliA3NZ83.
SMRiA3NZ83. Positions 7-351.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DHOase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0418.
HOGENOMiHOG000256259.
KOiK01465.
OMAiVAFEPLM.
OrthoDBiEOG6TFCMH.

Family and domain databases

HAMAPiMF_00219. PyrC_type1.
InterProiIPR006680. Amidohydro_1.
IPR004721. DHOdimr.
IPR002195. Dihydroorotase_CS.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
[Graphical view]
PIRSFiPIRSF001237. DHOdimr. 1 hit.
TIGRFAMsiTIGR00856. pyrC_dimer. 1 hit.
PROSITEiPS00482. DIHYDROOROTASE_1. 1 hit.
PS00483. DIHYDROOROTASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3NZ83-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNASVPASLT LARPDDWHLH VRDGAMLAAV LPHTARQFGR AIIMPNLKPP
60 70 80 90 100
VTTTAQAQAY RERILAAVPA GMTFEPLMTL YLTDNTPADE IRRARESGCV
110 120 130 140 150
HGVKLYPAGA TTNSDAGVTD LLGKCAKTLE AMQEVGMPLL VHGEVTDPSI
160 170 180 190 200
DLFDREKVFI DRVMEPLRRA LPGLKVVFEH ITTKDAADYV RDADAASGRI
210 220 230 240 250
GATITAHHLL YNRNAMFFGG IRPHYYCLPV LKRETHRIAL VEAATSGNPR
260 270 280 290 300
FFLGTDSAPH AKGAKEAACG CAGCYTALHA LELYAEAFDQ AGALDKLEGF
310 320 330 340 350
ASFFGADFYG LPRSAETVTL RRETWELPRE IDAGAGPVVP LRGGEAIGWR

LV
Length:352
Mass (Da):38,178
Last modified:April 3, 2007 - v1
Checksum:i88B2B9B04EB1F241
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000572 Genomic DNA. Translation: ABN92544.1.
RefSeqiYP_001067654.1. NC_009076.1.

Genome annotation databases

EnsemblBacteriaiABN92544; ABN92544; BURPS1106A_3417.
GeneIDi4899569.
KEGGibpl:BURPS1106A_3417.
PATRICi19225163. VBIBurPse14980_3225.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000572 Genomic DNA. Translation: ABN92544.1 .
RefSeqi YP_001067654.1. NC_009076.1.

3D structure databases

ProteinModelPortali A3NZ83.
SMRi A3NZ83. Positions 7-351.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 357348.BURPS1106A_3417.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABN92544 ; ABN92544 ; BURPS1106A_3417 .
GeneIDi 4899569.
KEGGi bpl:BURPS1106A_3417.
PATRICi 19225163. VBIBurPse14980_3225.

Phylogenomic databases

eggNOGi COG0418.
HOGENOMi HOG000256259.
KOi K01465.
OMAi VAFEPLM.
OrthoDBi EOG6TFCMH.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00117 .
BioCyci BPSE357348:GHVF-3417-MONOMER.

Family and domain databases

HAMAPi MF_00219. PyrC_type1.
InterProi IPR006680. Amidohydro_1.
IPR004721. DHOdimr.
IPR002195. Dihydroorotase_CS.
[Graphical view ]
Pfami PF01979. Amidohydro_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF001237. DHOdimr. 1 hit.
TIGRFAMsi TIGR00856. pyrC_dimer. 1 hit.
PROSITEi PS00482. DIHYDROOROTASE_1. 1 hit.
PS00483. DIHYDROOROTASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. DeShazer D., Woods D.E., Nierman W.C.
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1106aImported.

Entry informationi

Entry nameiA3NZ83_BURP0
AccessioniPrimary (citable) accession number: A3NZ83
Entry historyi
Integrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: November 26, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3