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A3NZ83 (A3NZ83_BURP0) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydroorotase HAMAP-Rule MF_00219
Short name=DHOase HAMAP-Rule MF_00219
EC=3.5.2.3 HAMAP-Rule MF_00219
Gene names
Name:pyrC HAMAP-Rule MF_00219 EMBL ABN92544.1
Ordered Locus Names:BURPS1106A_3417
OrganismBurkholderia pseudomallei (strain 1106a) [Complete proteome] [HAMAP]
Taxonomic identifier357348 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group ›

Protein attributes

Sequence length352 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate. HAMAP-Rule MF_00219 RuleBase RU003440 SAAS SAAS002195

Cofactor

Binds 2 zinc ions per subunit By similarity. HAMAP-Rule MF_00219 RuleBase RU003440 SAAS SAAS002195

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3. HAMAP-Rule MF_00219 RuleBase RU003440 SAAS SAAS002195

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00219 SAAS SAAS002195

Sequence similarities

Belongs to the DHOase family. Type 1 subfamily. HAMAP-Rule MF_00219 RuleBase RU003440

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding181Zinc 1 By similarity HAMAP-Rule MF_00219
Metal binding201Zinc 1 By similarity HAMAP-Rule MF_00219
Metal binding1041Zinc 1; via carbamate group By similarity HAMAP-Rule MF_00219
Metal binding1041Zinc 2; via carbamate group By similarity HAMAP-Rule MF_00219
Metal binding1421Zinc 2 By similarity HAMAP-Rule MF_00219
Metal binding1801Zinc 2 By similarity HAMAP-Rule MF_00219
Metal binding2561Zinc 1 By similarity HAMAP-Rule MF_00219

Amino acid modifications

Modified residue1041N6-carboxylysine By similarity HAMAP-Rule MF_00219

Sequences

Sequence LengthMass (Da)Tools
A3NZ83 [UniParc].

Last modified April 3, 2007. Version 1.
Checksum: 88B2B9B04EB1F241

FASTA35238,178
        10         20         30         40         50         60 
MNASVPASLT LARPDDWHLH VRDGAMLAAV LPHTARQFGR AIIMPNLKPP VTTTAQAQAY 

        70         80         90        100        110        120 
RERILAAVPA GMTFEPLMTL YLTDNTPADE IRRARESGCV HGVKLYPAGA TTNSDAGVTD 

       130        140        150        160        170        180 
LLGKCAKTLE AMQEVGMPLL VHGEVTDPSI DLFDREKVFI DRVMEPLRRA LPGLKVVFEH 

       190        200        210        220        230        240 
ITTKDAADYV RDADAASGRI GATITAHHLL YNRNAMFFGG IRPHYYCLPV LKRETHRIAL 

       250        260        270        280        290        300 
VEAATSGNPR FFLGTDSAPH AKGAKEAACG CAGCYTALHA LELYAEAFDQ AGALDKLEGF 

       310        320        330        340        350 
ASFFGADFYG LPRSAETVTL RRETWELPRE IDAGAGPVVP LRGGEAIGWR LV

« Hide

References

[1]DeShazer D., Woods D.E., Nierman W.C.
Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1106a.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000572 Genomic DNA. Translation: ABN92544.1.
RefSeqYP_001067654.1. NC_009076.1.

3D structure databases

ProteinModelPortalA3NZ83.
SMRA3NZ83. Positions 7-351.
ModBaseSearch...

Protein-protein interaction databases

STRING357348.BURPS1106A_3417.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABN92544; ABN92544; BURPS1106A_3417.
GeneID4899569.
KEGGbpl:BURPS1106A_3417.
PATRIC19225163. VBIBurPse14980_3225.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0418.
HOGENOMHOG000256259.
KOK01465.
OMAMTLYLTE.
ProtClustDBPRK05451.

Enzyme and pathway databases

BioCycBPSE357348:GHVF-6606-MONOMER.
UniPathwayUPA00070; UER00117.

Family and domain databases

HAMAPMF_00219. PyrC_type1.
InterProIPR006680. Amidohydro_1.
IPR004721. DHOdimr.
IPR002195. Dihydroorotase_CS.
[Graphical view]
PfamPF01979. Amidohydro_1. 1 hit.
[Graphical view]
PIRSFPIRSF001237. DHOdimr. 1 hit.
TIGRFAMsTIGR00856. pyrC_dimer. 1 hit.
PROSITEPS00482. DIHYDROOROTASE_1. 1 hit.
PS00483. DIHYDROOROTASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA3NZ83_BURP0
AccessionPrimary (citable) accession number: A3NZ83
Entry history
Integrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: May 1, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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