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A3NZ83

- A3NZ83_BURP0

UniProt

A3NZ83 - A3NZ83_BURP0

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Protein
Dihydroorotase
Gene
pyrC, BURPS1106A_3417
Organism
Burkholderia pseudomallei (strain 1106a)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate.UniRule annotationSAAS annotations

Cofactori

Binds 2 zinc ions per subunit By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi18 – 181Zinc 1; via tele nitrogen By similarityUniRule annotation
Metal bindingi20 – 201Zinc 1; via tele nitrogen By similarityUniRule annotation
Metal bindingi104 – 1041Zinc 1; via carbamate group By similarityUniRule annotation
Metal bindingi104 – 1041Zinc 2; via carbamate group By similarityUniRule annotation
Metal bindingi142 – 1421Zinc 2; via pros nitrogen By similarityUniRule annotation
Metal bindingi180 – 1801Zinc 2; via tele nitrogen By similarityUniRule annotation
Metal bindingi256 – 2561Zinc 1 By similarityUniRule annotation

GO - Molecular functioni

  1. dihydroorotase activity Source: UniProtKB-HAMAP
  2. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  2. pyrimidine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Pyrimidine biosynthesisUniRule annotationSAAS annotations

Keywords - Ligandi

Metal-bindingUniRule annotationSAAS annotations, ZincUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciBPSE357348:GHVF-3417-MONOMER.
UniPathwayiUPA00070; UER00117.

Names & Taxonomyi

Protein namesi
Recommended name:
DihydroorotaseUniRule annotation (EC:3.5.2.3UniRule annotation)
Short name:
DHOaseUniRule annotation
Gene namesi
Name:pyrCUniRule annotationImported
Ordered Locus Names:BURPS1106A_3417Imported
OrganismiBurkholderia pseudomallei (strain 1106a)Imported
Taxonomic identifieri357348 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
ProteomesiUP000006738: Chromosome I

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei104 – 1041N6-carboxylysine By similarityUniRule annotation

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotationSAAS annotations

Protein-protein interaction databases

STRINGi357348.BURPS1106A_3417.

Structurei

3D structure databases

ProteinModelPortaliA3NZ83.
SMRiA3NZ83. Positions 7-351.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0418.
HOGENOMiHOG000256259.
KOiK01465.
OMAiVAFEPLM.
OrthoDBiEOG6TFCMH.

Family and domain databases

HAMAPiMF_00219. PyrC_type1.
InterProiIPR006680. Amidohydro_1.
IPR004721. DHOdimr.
IPR002195. Dihydroorotase_CS.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
[Graphical view]
PIRSFiPIRSF001237. DHOdimr. 1 hit.
TIGRFAMsiTIGR00856. pyrC_dimer. 1 hit.
PROSITEiPS00482. DIHYDROOROTASE_1. 1 hit.
PS00483. DIHYDROOROTASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3NZ83-1 [UniParc]FASTAAdd to Basket

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MNASVPASLT LARPDDWHLH VRDGAMLAAV LPHTARQFGR AIIMPNLKPP    50
VTTTAQAQAY RERILAAVPA GMTFEPLMTL YLTDNTPADE IRRARESGCV 100
HGVKLYPAGA TTNSDAGVTD LLGKCAKTLE AMQEVGMPLL VHGEVTDPSI 150
DLFDREKVFI DRVMEPLRRA LPGLKVVFEH ITTKDAADYV RDADAASGRI 200
GATITAHHLL YNRNAMFFGG IRPHYYCLPV LKRETHRIAL VEAATSGNPR 250
FFLGTDSAPH AKGAKEAACG CAGCYTALHA LELYAEAFDQ AGALDKLEGF 300
ASFFGADFYG LPRSAETVTL RRETWELPRE IDAGAGPVVP LRGGEAIGWR 350
LV 352
Length:352
Mass (Da):38,178
Last modified:April 3, 2007 - v1
Checksum:i88B2B9B04EB1F241
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000572 Genomic DNA. Translation: ABN92544.1.
RefSeqiYP_001067654.1. NC_009076.1.

Genome annotation databases

EnsemblBacteriaiABN92544; ABN92544; BURPS1106A_3417.
GeneIDi4899569.
KEGGibpl:BURPS1106A_3417.
PATRICi19225163. VBIBurPse14980_3225.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000572 Genomic DNA. Translation: ABN92544.1 .
RefSeqi YP_001067654.1. NC_009076.1.

3D structure databases

ProteinModelPortali A3NZ83.
SMRi A3NZ83. Positions 7-351.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 357348.BURPS1106A_3417.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABN92544 ; ABN92544 ; BURPS1106A_3417 .
GeneIDi 4899569.
KEGGi bpl:BURPS1106A_3417.
PATRICi 19225163. VBIBurPse14980_3225.

Phylogenomic databases

eggNOGi COG0418.
HOGENOMi HOG000256259.
KOi K01465.
OMAi VAFEPLM.
OrthoDBi EOG6TFCMH.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00117 .
BioCyci BPSE357348:GHVF-3417-MONOMER.

Family and domain databases

HAMAPi MF_00219. PyrC_type1.
InterProi IPR006680. Amidohydro_1.
IPR004721. DHOdimr.
IPR002195. Dihydroorotase_CS.
[Graphical view ]
Pfami PF01979. Amidohydro_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF001237. DHOdimr. 1 hit.
TIGRFAMsi TIGR00856. pyrC_dimer. 1 hit.
PROSITEi PS00482. DIHYDROOROTASE_1. 1 hit.
PS00483. DIHYDROOROTASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. DeShazer D., Woods D.E., Nierman W.C.
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1106aImported.

Entry informationi

Entry nameiA3NZ83_BURP0
AccessioniPrimary (citable) accession number: A3NZ83
Entry historyi
Integrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: September 3, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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