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A3NZ83

- A3NZ83_BURP0

UniProt

A3NZ83 - A3NZ83_BURP0

Protein

Dihydroorotase

Gene

pyrC

Organism
Burkholderia pseudomallei (strain 1106a)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate.UniRule annotationSAAS annotation

    Cofactori

    Binds 2 zinc ions per subunit.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi18 – 181Zinc 1; via tele nitrogenUniRule annotation
    Metal bindingi20 – 201Zinc 1; via tele nitrogenUniRule annotation
    Metal bindingi104 – 1041Zinc 1; via carbamate groupUniRule annotation
    Metal bindingi104 – 1041Zinc 2; via carbamate groupUniRule annotation
    Metal bindingi142 – 1421Zinc 2; via pros nitrogenUniRule annotation
    Metal bindingi180 – 1801Zinc 2; via tele nitrogenUniRule annotation
    Metal bindingi256 – 2561Zinc 1UniRule annotation

    GO - Molecular functioni

    1. dihydroorotase activity Source: UniProtKB-HAMAP
    2. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
    2. pyrimidine nucleobase biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    HydrolaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Pyrimidine biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    Metal-bindingUniRule annotationSAAS annotation, ZincUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciBPSE357348:GHVF-3417-MONOMER.
    UniPathwayiUPA00070; UER00117.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DihydroorotaseUniRule annotation (EC:3.5.2.3UniRule annotation)
    Short name:
    DHOaseUniRule annotation
    Gene namesi
    Name:pyrCUniRule annotationImported
    Ordered Locus Names:BURPS1106A_3417Imported
    OrganismiBurkholderia pseudomallei (strain 1106a)Imported
    Taxonomic identifieri357348 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
    ProteomesiUP000006738: Chromosome I

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei104 – 1041N6-carboxylysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotationSAAS annotation

    Protein-protein interaction databases

    STRINGi357348.BURPS1106A_3417.

    Structurei

    3D structure databases

    ProteinModelPortaliA3NZ83.
    SMRiA3NZ83. Positions 7-351.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DHOase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0418.
    HOGENOMiHOG000256259.
    KOiK01465.
    OMAiVAFEPLM.
    OrthoDBiEOG6TFCMH.

    Family and domain databases

    HAMAPiMF_00219. PyrC_type1.
    InterProiIPR006680. Amidohydro_1.
    IPR004721. DHOdimr.
    IPR002195. Dihydroorotase_CS.
    [Graphical view]
    PfamiPF01979. Amidohydro_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001237. DHOdimr. 1 hit.
    TIGRFAMsiTIGR00856. pyrC_dimer. 1 hit.
    PROSITEiPS00482. DIHYDROOROTASE_1. 1 hit.
    PS00483. DIHYDROOROTASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A3NZ83-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNASVPASLT LARPDDWHLH VRDGAMLAAV LPHTARQFGR AIIMPNLKPP    50
    VTTTAQAQAY RERILAAVPA GMTFEPLMTL YLTDNTPADE IRRARESGCV 100
    HGVKLYPAGA TTNSDAGVTD LLGKCAKTLE AMQEVGMPLL VHGEVTDPSI 150
    DLFDREKVFI DRVMEPLRRA LPGLKVVFEH ITTKDAADYV RDADAASGRI 200
    GATITAHHLL YNRNAMFFGG IRPHYYCLPV LKRETHRIAL VEAATSGNPR 250
    FFLGTDSAPH AKGAKEAACG CAGCYTALHA LELYAEAFDQ AGALDKLEGF 300
    ASFFGADFYG LPRSAETVTL RRETWELPRE IDAGAGPVVP LRGGEAIGWR 350
    LV 352
    Length:352
    Mass (Da):38,178
    Last modified:April 3, 2007 - v1
    Checksum:i88B2B9B04EB1F241
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000572 Genomic DNA. Translation: ABN92544.1.
    RefSeqiYP_001067654.1. NC_009076.1.

    Genome annotation databases

    EnsemblBacteriaiABN92544; ABN92544; BURPS1106A_3417.
    GeneIDi4899569.
    KEGGibpl:BURPS1106A_3417.
    PATRICi19225163. VBIBurPse14980_3225.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000572 Genomic DNA. Translation: ABN92544.1 .
    RefSeqi YP_001067654.1. NC_009076.1.

    3D structure databases

    ProteinModelPortali A3NZ83.
    SMRi A3NZ83. Positions 7-351.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 357348.BURPS1106A_3417.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABN92544 ; ABN92544 ; BURPS1106A_3417 .
    GeneIDi 4899569.
    KEGGi bpl:BURPS1106A_3417.
    PATRICi 19225163. VBIBurPse14980_3225.

    Phylogenomic databases

    eggNOGi COG0418.
    HOGENOMi HOG000256259.
    KOi K01465.
    OMAi VAFEPLM.
    OrthoDBi EOG6TFCMH.

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00117 .
    BioCyci BPSE357348:GHVF-3417-MONOMER.

    Family and domain databases

    HAMAPi MF_00219. PyrC_type1.
    InterProi IPR006680. Amidohydro_1.
    IPR004721. DHOdimr.
    IPR002195. Dihydroorotase_CS.
    [Graphical view ]
    Pfami PF01979. Amidohydro_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001237. DHOdimr. 1 hit.
    TIGRFAMsi TIGR00856. pyrC_dimer. 1 hit.
    PROSITEi PS00482. DIHYDROOROTASE_1. 1 hit.
    PS00483. DIHYDROOROTASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. DeShazer D., Woods D.E., Nierman W.C.
      Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1106aImported.

    Entry informationi

    Entry nameiA3NZ83_BURP0
    AccessioniPrimary (citable) accession number: A3NZ83
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 3, 2007
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3