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A3NYA9

- UPPP2_BURP0

UniProt

A3NYA9 - UPPP2_BURP0

Protein

Undecaprenyl-diphosphatase 2

Gene

uppP2

Organism
Burkholderia pseudomallei (strain 1106a)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciBPSE357348:GHVF-3092-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphatase 2UniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance protein 2UniRule annotation
    Undecaprenyl pyrophosphate phosphatase 2UniRule annotation
    Gene namesi
    Name:uppP2UniRule annotation
    Ordered Locus Names:BURPS1106A_3092
    OrganismiBurkholderia pseudomallei (strain 1106a)
    Taxonomic identifieri357348 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
    ProteomesiUP000006738: Chromosome I

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 276276Undecaprenyl-diphosphatase 2PRO_0000303024Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi357348.BURPS1106A_3092.

    Structurei

    3D structure databases

    ProteinModelPortaliA3NYA9.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei85 – 10521HelicalUniRule annotationAdd
    BLAST
    Transmembranei108 – 12821HelicalUniRule annotationAdd
    BLAST
    Transmembranei187 – 20721HelicalUniRule annotationAdd
    BLAST
    Transmembranei217 – 23721HelicalUniRule annotationAdd
    BLAST
    Transmembranei253 – 27321HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218356.
    KOiK06153.
    OMAiWRKISSS.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A3NYA9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDWILICKAL ALGIVEGLTE FLPVSSTGHL IVAGSFLRFH PEQAKTFDVV    50
    IQFGAILAVC WEYRRRIIDV VTGLPAQREA RRFTMNVVIA TVPAVALALL 100
    FEKTIKSVLF APVPVAVALV VGGAAILWVE GRQRERSEPA RVQSIDALTP 150
    FDALKVGLAQ CCALIPGMSR SGSTIIGGML FGLERRVATE FSFFLAIPVI 200
    FGATLYETAK DWRAFNVDSV GLFAIGLVAA FVSAFACVRW LLRYVASHDF 250
    TAFAWYRIAF GLFVLLVGYS GWIEWT 276
    Length:276
    Mass (Da):30,284
    Last modified:April 3, 2007 - v1
    Checksum:i608BFAFD49296177
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000572 Genomic DNA. Translation: ABN90854.1.
    RefSeqiYP_001067330.1. NC_009076.1.

    Genome annotation databases

    EnsemblBacteriaiABN90854; ABN90854; BURPS1106A_3092.
    GeneIDi4900188.
    KEGGibpl:BURPS1106A_3092.
    PATRICi19224534. VBIBurPse14980_2912.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000572 Genomic DNA. Translation: ABN90854.1 .
    RefSeqi YP_001067330.1. NC_009076.1.

    3D structure databases

    ProteinModelPortali A3NYA9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 357348.BURPS1106A_3092.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABN90854 ; ABN90854 ; BURPS1106A_3092 .
    GeneIDi 4900188.
    KEGGi bpl:BURPS1106A_3092.
    PATRICi 19224534. VBIBurPse14980_2912.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218356.
    KOi K06153.
    OMAi WRKISSS.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci BPSE357348:GHVF-3092-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. DeShazer D., Woods D.E., Nierman W.C.
      Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1106a.

    Entry informationi

    Entry nameiUPPP2_BURP0
    AccessioniPrimary (citable) accession number: A3NYA9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3