A3NYA9 (UPPP2_BURP0) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase 2
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein 2
Undecaprenyl pyrophosphate phosphatase 2

Gene names

Name:	uppP2
Ordered Locus Names:	BURPS1106A_3092

Organism

Burkholderia pseudomallei (strain 1106a) [Complete proteome] [HAMAP]

Taxonomic identifier

357348 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group › Burkholderia pseudomallei

Protein attributes

Sequence length	276 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 276	276	Undecaprenyl-diphosphatase 2 HAMAP-Rule MF_01006		PRO_0000303024
Regions
	Transmembrane	85 – 105	21	Helical; Potential
	Transmembrane	108 – 128	21	Helical; Potential
	Transmembrane	187 – 207	21	Helical; Potential
	Transmembrane	217 – 237	21	Helical; Potential
	Transmembrane	253 – 273	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	A3NYA9 [UniParc]. Last modified April 3, 2007. Version 1. Checksum: 608BFAFD49296177	FASTA	276	30,284
	10 20 30 40 50 60 MDWILICKAL ALGIVEGLTE FLPVSSTGHL IVAGSFLRFH PEQAKTFDVV IQFGAILAVC 70 80 90 100 110 120 WEYRRRIIDV VTGLPAQREA RRFTMNVVIA TVPAVALALL FEKTIKSVLF APVPVAVALV 130 140 150 160 170 180 VGGAAILWVE GRQRERSEPA RVQSIDALTP FDALKVGLAQ CCALIPGMSR SGSTIIGGML 190 200 210 220 230 240 FGLERRVATE FSFFLAIPVI FGATLYETAK DWRAFNVDSV GLFAIGLVAA FVSAFACVRW 250 260 270 LLRYVASHDF TAFAWYRIAF GLFVLLVGYS GWIEWT

References

[1]	DeShazer D., Woods D.E., Nierman W.C. Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1106a.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000572 Genomic DNA. Translation: ABN90854.1.
RefSeq	YP_001067330.1. NC_009076.1.
3D structure databases
ProteinModelPortal	A3NYA9.
ModBase	Search...
Protein-protein interaction databases
STRING	357348.BURPS1106A_3092.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABN90854; ABN90854; BURPS1106A_3092.
GeneID	4900188.
KEGG	bpl:BURPS1106A_3092.
PATRIC	19224534. VBIBurPse14980_2912.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HOG000218356.
KO	K06153.
OMA	RWLLRYI.
ProtClustDB	PRK00281.
Enzyme and pathway databases
BioCyc	BPSE357348:GHVF-6282-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP2_BURP0

Accession

Primary (citable) accession number: A3NYA9

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	April 3, 2007
Last modified:	May 1, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program