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A3NY82

- GSA_BURP0

UniProt

A3NY82 - GSA_BURP0

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Protein
Glutamate-1-semialdehyde 2,1-aminomutase
Gene
hemL, BURPS1106A_3064
Organism
Burkholderia pseudomallei (strain 1106a)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciBPSE357348:GHVF-3064-MONOMER.
UniPathwayiUPA00251; UER00317.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase (EC:5.4.3.8)
Short name:
GSA
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name:
GSA-AT
Gene namesi
Name:hemL
Ordered Locus Names:BURPS1106A_3064
OrganismiBurkholderia pseudomallei (strain 1106a)
Taxonomic identifieri357348 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
ProteomesiUP000006738: Chromosome I

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 427427Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation
PRO_0000300897Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei265 – 2651N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi357348.BURPS1106A_3064.

Structurei

3D structure databases

ProteinModelPortaliA3NY82.
SMRiA3NY82. Positions 4-421.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0001.
HOGENOMiHOG000020210.
KOiK01845.
OMAiHGHANAF.
OrthoDBiEOG6QVRHN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3NY82-1 [UniParc]FASTAAdd to Basket

« Hide

MSNNQTLFER AQRIIPGGVN SPVRAFRSVG GTPRFVARAQ GAYFWDADGK    50
RYIDYIGSWG PMIVGHVHPD VLAAVQRVLA DGFSFGAPTE AEIEIAEEIC 100
KLVPSIEQVR MVSSGTEATM SALRLARGFT GRSRIVKFEG CYHGHADSLL 150
VKAGSGLLTF GNPTSAGVPA DVAKHTTVLE YNNVAALEEA FAAFGGEIAA 200
VIVEPVAGNM NLVRGTPEFL NALRALTAKH GAVLIFDEVM CGFRVALGGA 250
QQHYGITPDL TCLGKVIGGG MPAAAFGGRG DIMSHLAPLG GVYQAGTLSG 300
NPVAVAAGLA TLRLIQAPGF HDALADKTRR LADGLAAEAR AAGVPFSADA 350
IGGMFGLYFT EQVPASFADV TKSDIERFNR FFHLMLDTGV YFAPSAYEAG 400
FVSSAHDDAT LDATLDAARR AFAALRA 427
Length:427
Mass (Da):44,840
Last modified:April 3, 2007 - v1
Checksum:iA10FAA6DC56C37C4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000572 Genomic DNA. Translation: ABN89793.1.
RefSeqiYP_001067303.1. NC_009076.1.

Genome annotation databases

EnsemblBacteriaiABN89793; ABN89793; BURPS1106A_3064.
GeneIDi4902712.
KEGGibpl:BURPS1106A_3064.
PATRICi19224484. VBIBurPse14980_2888.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000572 Genomic DNA. Translation: ABN89793.1 .
RefSeqi YP_001067303.1. NC_009076.1.

3D structure databases

ProteinModelPortali A3NY82.
SMRi A3NY82. Positions 4-421.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 357348.BURPS1106A_3064.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABN89793 ; ABN89793 ; BURPS1106A_3064 .
GeneIDi 4902712.
KEGGi bpl:BURPS1106A_3064.
PATRICi 19224484. VBIBurPse14980_2888.

Phylogenomic databases

eggNOGi COG0001.
HOGENOMi HOG000020210.
KOi K01845.
OMAi HGHANAF.
OrthoDBi EOG6QVRHN.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .
BioCyci BPSE357348:GHVF-3064-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. DeShazer D., Woods D.E., Nierman W.C.
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1106a.

Entry informationi

Entry nameiGSA_BURP0
AccessioniPrimary (citable) accession number: A3NY82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: April 3, 2007
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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