Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A3NXX5 (A3NXX5_BURP0) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein attributes

Sequence length866 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. HAMAP-Rule MF_01897

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA. HAMAP-Rule MF_01897 SAAS SAAS006691

Subunit structure

Heterotetramer, composed of two GyrA and two GyrB chains. Within the heterotetramer, GyrA contains the active site tyrosine that forms a covalent intermediate with the DNA, while GyrB contributes the cofactor binding sites and catalyzes ATP hydrolysis By similarity. HAMAP-Rule MF_01897

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01897.

Sequence similarities

Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP-Rule MF_01897

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1221O-(5'-phospho-DNA)-tyrosine intermediate By similarity HAMAP-Rule MF_01897

Sequences

Sequence LengthMass (Da)Tools
A3NXX5 [UniParc].

Last modified April 3, 2007. Version 1.
Checksum: CCCCAF2839748156

FASTA86696,159
        10         20         30         40         50         60 
MDQFAKETLP TSLEEEMRKS YLDYAMSVIV GRALPDVRDG LKPVHRRVLF AMHELNNDWN 

        70         80         90        100        110        120 
RPYKKSARIV GDVIGKYHPH GDTAVYDTIV RMAQDFSLRY MLVDGQGNFG SVDGDNAAAM 

       130        140        150        160        170        180 
RYTEIRMAKI GHELLADIDK ETVDFGPNYD GSEMQPLILP SRIPNLLING SSGIAVGMAT 

       190        200        210        220        230        240 
NIPPHNLNEV VDACLYLLNN PQASVDELIE IIPAPDFPTA GIIYGVAGVR DGYRTGRGRV 

       250        260        270        280        290        300 
VMRAATHFEE IDRGQRMAII VDELPYQVNK RSLLERIAEL VNEKKLEGIS DIRDESDKSG 

       310        320        330        340        350        360 
MRVVIELKRG EVPEVVLNNL YKATQLQDTF GMNMVALVDN QPKLLNLREI LQCFLSHRRE 

       370        380        390        400        410        420 
VLTRRTVYEL RKARERGHVL EGLAVALANI DEFIAIIKAA PTPPIAKQEL MAKSWDSSLV 

       430        440        450        460        470        480 
RDMLTRAETE NAAAGGRDAY RPEGLSPAFG MQGDGLYRLS DTQAQEILQM RLQRLTGLEQ 

       490        500        510        520        530        540 
DKIIGEYRDV MAQIADLLDI LARPERITTL IGDELTQVKA EFGDARRSKI ELNATELNTE 

       550        560        570        580        590        600 
DLITPQDMVV TMSHAGYVKS QPLSEYRAQK RGGRGKQATQ MKEDDWIETL FIANTHDYIL 

       610        620        630        640        650        660 
CFSNRGRVYW VKVYEVPQGS RNSRGRPIVN MFPLQDGEKI NVVLPVKEFS ADKYVFMTTA 

       670        680        690        700        710        720 
LGTVKKTPLE AFSRPMKKGI IAVGLDDGDY LIGAAITDGA HDVMLFSDAG KAVRFDENDV 

       730        740        750        760        770        780 
RPMGREARGV RGMQLDDAQQ VIAMLVAGSE EQSVLTATEN GYGKRTPITE YTRHGRGTKG 

       790        800        810        820        830        840 
MIAIQTSERN GRVVAATLVD PEDQIMLITT AGVLIRTRVS EIREMGRATQ GVTLISLDEG 

       850        860 
TKLSGLQQIA EADADADDDA VEGGDA 

« Hide

References

[1]DeShazer D., Woods D.E., Nierman W.C.
Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1106a EMBL ABN90955.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000572 Genomic DNA. Translation: ABN90955.1.
RefSeqYP_001067196.1. NC_009076.1.

3D structure databases

ProteinModelPortalA3NXX5.
SMRA3NXX5. Positions 30-530, 544-851.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING357348.BURPS1106A_2951.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABN90955; ABN90955; BURPS1106A_2951.
GeneID4903090.
KEGGbpl:BURPS1106A_2951.
PATRIC19224266. VBIBurPse14980_2784.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0188.
HOGENOMHOG000076278.
KOK02469.
OMAETVDWVP.
OrthoDBEOG661H5V.
ProtClustDBPRK05560.

Enzyme and pathway databases

BioCycBPSE357348:GHVF-2951-MONOMER.

Family and domain databases

Gene3D1.10.268.10. 1 hit.
3.30.1360.40. 1 hit.
3.90.199.10. 1 hit.
HAMAPMF_01897. GyrA.
InterProIPR024946. Arg_repress_C-like.
IPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013757. Topo_IIA_A_a.
IPR013760. Topo_IIA_like_dom.
[Graphical view]
PfamPF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMSSF56719. SSF56719. 1 hit.
TIGRFAMsTIGR01063. gyrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA3NXX5_BURP0
AccessionPrimary (citable) accession number: A3NXX5
Entry history
Integrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: April 16, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)