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Protein

Argininosuccinate lyase

Gene

argH

Organism
Burkholderia pseudomallei (strain 1106a)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.UniRule annotationSAAS annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotationSAAS annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (arcB), Ornithine carbamoyltransferase (argF)
  2. Argininosuccinate synthase (argG), Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH), Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotationImported

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00068; UER00114.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate lyaseUniRule annotationSAAS annotation (EC:4.3.2.1UniRule annotationSAAS annotation)
Short name:
ASALUniRule annotation
Alternative name(s):
ArginosuccinaseUniRule annotation
Gene namesi
Name:argHUniRule annotationImported
Ordered Locus Names:BURPS1106A_2017Imported
OrganismiBurkholderia pseudomallei (strain 1106a)Imported
Taxonomic identifieri357348 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
Proteomesi
  • UP000006738 Componenti: Chromosome I

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliA3NVB1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 305Lyase_1InterPro annotationAdd BLAST295
Domaini370 – 427ASL_C2InterPro annotationAdd BLAST58

Sequence similaritiesi

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000242744.
KOiK01755.
OMAiPQIHQEN.

Family and domain databases

CDDicd01359. Argininosuccinate_lyase. 1 hit.
Gene3Di1.10.275.10. 1 hit.
HAMAPiMF_00006. Arg_succ_lyase. 1 hit.
InterProiIPR029419. Arg_succ_lyase_C.
IPR009049. Argininosuccinate_lyase.
IPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PTHR11444:SF3. PTHR11444:SF3. 1 hit.
PfamiPF14698. ASL_C2. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00838. argH. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3NVB1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNPMANPWA GRFSQTMTDS LVAFNTSLPL ETRLFEADID GTAAHVEMLH
60 70 80 90 100
ATGLLETAEH EALARALDEI RAAWRAGEIR LSPALEDIHM NLETLLVDKL
110 120 130 140 150
GELGKKTHTA RSRNDQQASA QRLYFMRSTR ELVDAIDALQ RAILEHGERH
160 170 180 190 200
DALVMPSYTH LQRAEFTYYA HWLATYVVML ERDRSRFVDA LARADQCPLG
210 220 230 240 250
ACASTGTSLP IDRRRSASRL GFREPTLHSI DSVSDRDYLV EFCSHAANLM
260 270 280 290 300
IHLSRLSEEL ISFTSQEFGF IALADGYCTG SSIMPQKKNP DVPELVRGKA
310 320 330 340 350
ASVIGNAMSL MALLKALPLG YNKDLQEDKT AWFAALDNCM SSLAILTELV
360 370 380 390 400
RTMAPVPDRM RQATLGGHII ATEYANYLVR KGMPFREAHR VVGELVKTAD
410 420 430 440 450
ARGVDVSALP QAAFAEASPL FGDDIGRVTV EDMVSRKNSY GSCGDQALGE
460
LLAQLRSMLD AHRLGR
Length:466
Mass (Da):51,493
Last modified:April 3, 2007 - v1
Checksum:iAD427DD85576B7FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000572 Genomic DNA. Translation: ABN89762.1.
RefSeqiWP_004531290.1. NC_009076.1.

Genome annotation databases

EnsemblBacteriaiABN89762; ABN89762; BURPS1106A_2017.
KEGGibpl:BURPS1106A_2017.
PATRICi19222525. VBIBurPse14980_1930.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000572 Genomic DNA. Translation: ABN89762.1.
RefSeqiWP_004531290.1. NC_009076.1.

3D structure databases

ProteinModelPortaliA3NVB1.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABN89762; ABN89762; BURPS1106A_2017.
KEGGibpl:BURPS1106A_2017.
PATRICi19222525. VBIBurPse14980_1930.

Phylogenomic databases

HOGENOMiHOG000242744.
KOiK01755.
OMAiPQIHQEN.

Enzyme and pathway databases

UniPathwayiUPA00068; UER00114.

Family and domain databases

CDDicd01359. Argininosuccinate_lyase. 1 hit.
Gene3Di1.10.275.10. 1 hit.
HAMAPiMF_00006. Arg_succ_lyase. 1 hit.
InterProiIPR029419. Arg_succ_lyase_C.
IPR009049. Argininosuccinate_lyase.
IPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PTHR11444:SF3. PTHR11444:SF3. 1 hit.
PfamiPF14698. ASL_C2. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00838. argH. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA3NVB1_BURP0
AccessioniPrimary (citable) accession number: A3NVB1
Entry historyi
Integrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: November 30, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.