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A3NTZ5

- UPPP1_BURP0

UniProt

A3NTZ5 - UPPP1_BURP0

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Protein
Undecaprenyl-diphosphatase 1
Gene
uppP1, BURPS1106A_1544
Organism
Burkholderia pseudomallei (strain 1106a)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciBPSE357348:GHVF-1545-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase 1 (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein 1
Undecaprenyl pyrophosphate phosphatase 1
Gene namesi
Name:uppP1
Ordered Locus Names:BURPS1106A_1544
OrganismiBurkholderia pseudomallei (strain 1106a)
Taxonomic identifieri357348 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
ProteomesiUP000006738: Chromosome I

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121Helical; Reviewed prediction
Add
BLAST
Transmembranei44 – 6421Helical; Reviewed prediction
Add
BLAST
Transmembranei87 – 10721Helical; Reviewed prediction
Add
BLAST
Transmembranei114 – 13421Helical; Reviewed prediction
Add
BLAST
Transmembranei150 – 17021Helical; Reviewed prediction
Add
BLAST
Transmembranei190 – 21021Helical; Reviewed prediction
Add
BLAST
Transmembranei222 – 24221Helical; Reviewed prediction
Add
BLAST
Transmembranei251 – 27121Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 276276Undecaprenyl-diphosphatase 1UniRule annotation
PRO_0000303023Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi357348.BURPS1106A_1544.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218357.
KOiK06153.
OMAiNANEAVD.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3NTZ5-1 [UniParc]FASTAAdd to Basket

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MSLWFLVFLS VLQGVTELFP VSSLGHTLLV PALFGMHIDK HAPQLLPFLV    50
ALHLGTALAL LWYFRERWIA LIAGFFASLN GRKNDEGHLM WALIIGTIPT 100
GLVGLLLEKR IERVFHDLRI VAAALIINGV LLWLGDRIQR ARAHRPPEKL 150
TFKQAFFVGL AQVGALIPGF SRSGLTMIAG NAAGLTADKA AEFSFLLGTP 200
IIFAAGLLEL PKLFHAPDQL ADALLGGVLT AIAAYLSVRF LMRYFEGRGR 250
LASFGLYCVL AGLFCLGWFM FHAQPV 276
Length:276
Mass (Da):30,247
Last modified:April 3, 2007 - v1
Checksum:i27C258F7FAC6845D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000572 Genomic DNA. Translation: ABN90511.1.
RefSeqiYP_001065816.1. NC_009076.1.

Genome annotation databases

EnsemblBacteriaiABN90511; ABN90511; BURPS1106A_1544.
GeneIDi4901658.
KEGGibpl:BURPS1106A_1544.
PATRICi19221623. VBIBurPse14980_1487.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000572 Genomic DNA. Translation: ABN90511.1 .
RefSeqi YP_001065816.1. NC_009076.1.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 357348.BURPS1106A_1544.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABN90511 ; ABN90511 ; BURPS1106A_1544 .
GeneIDi 4901658.
KEGGi bpl:BURPS1106A_1544.
PATRICi 19221623. VBIBurPse14980_1487.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218357.
KOi K06153.
OMAi NANEAVD.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci BPSE357348:GHVF-1545-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. DeShazer D., Woods D.E., Nierman W.C.
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1106a.

Entry informationi

Entry nameiUPPP1_BURP0
AccessioniPrimary (citable) accession number: A3NTZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: April 3, 2007
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi