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A3NSB9

- A3NSB9_BURP0

UniProt

A3NSB9 - A3NSB9_BURP0

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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Burkholderia pseudomallei (strain 1106a)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.UniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciBPSE357348:GHVF-958-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdImported
Ordered Locus Names:BURPS1106A_0960Imported
OrganismiBurkholderia pseudomallei (strain 1106a)Imported
Taxonomic identifieri357348 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
ProteomesiUP000006738: Chromosome I

Interactioni

Protein-protein interaction databases

STRINGi357348.BURPS1106A_0960.

Structurei

3D structure databases

ProteinModelPortaliA3NSB9.
SMRiA3NSB9. Positions 6-418.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000021113.
KOiK00031.
OMAiRYAIDND.
OrthoDBiEOG6SNDTP.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3NSB9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPYQHIKVPE GGDKITVNKD FSLNVSDQPI IPYIEGDGTG FDITPVMIKV
60 70 80 90 100
VDAAVEKAYG GKKKIHWMEI YAGEKATKVY GPDVWLPEET LQVLKEYVVS
110 120 130 140 150
IKGPLTTPVG GGIRSLNVAL RQELDLYVCL RPIQYFKGVP SPVREPEKTN
160 170 180 190 200
MVIFRENSED IYAGIEWAAE SEQAKKVIKF LQEEMGVKKI RFPQTSGIGI
210 220 230 240 250
KPVSKEGTER LVRKAIQYAI DNDRKSVTLV HKGNIMKFTE GAFRDAGYAL
260 270 280 290 300
AQKEFGAELI DGGPWMKFKN PKTGNEIVVK DSIADAFLQQ ILLRPAEYDV
310 320 330 340 350
IATLNLNGDY ISDALAAQVG GIGIAPGANL SDSVAMFEAT HGTAPKYAGK
360 370 380 390 400
DYVNPGSEIL SAEMMLRHLG WTEAADVIIS AMEKSIKQKR VTYDFARLME
410
GATQVSCSGF GQVLIENME
Length:419
Mass (Da):46,146
Last modified:April 3, 2007 - v1
Checksum:iF85E7112F2CB3C69
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000572 Genomic DNA. Translation: ABN90528.1.
RefSeqiYP_001065240.1. NC_009076.1.

Genome annotation databases

EnsemblBacteriaiABN90528; ABN90528; BURPS1106A_0960.
GeneIDi4899455.
KEGGibpl:BURPS1106A_0960.
PATRICi19220468. VBIBurPse14980_0918.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000572 Genomic DNA. Translation: ABN90528.1 .
RefSeqi YP_001065240.1. NC_009076.1.

3D structure databases

ProteinModelPortali A3NSB9.
SMRi A3NSB9. Positions 6-418.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 357348.BURPS1106A_0960.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABN90528 ; ABN90528 ; BURPS1106A_0960 .
GeneIDi 4899455.
KEGGi bpl:BURPS1106A_0960.
PATRICi 19220468. VBIBurPse14980_0918.

Phylogenomic databases

eggNOGi COG0538.
HOGENOMi HOG000021113.
KOi K00031.
OMAi RYAIDND.
OrthoDBi EOG6SNDTP.

Enzyme and pathway databases

BioCyci BPSE357348:GHVF-958-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. DeShazer D., Woods D.E., Nierman W.C.
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1106aImported.

Entry informationi

Entry nameiA3NSB9_BURP0
AccessioniPrimary (citable) accession number: A3NSB9
Entry historyi
Integrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: November 26, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3