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Protein

Ornithine carbamoyltransferase

Gene

argF

Organism
Burkholderia pseudomallei (strain 1106a)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.SAAS annotation

Catalytic activityi

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.UniRule annotationSAAS annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (arcB), Ornithine carbamoyltransferase (argF)
  2. Argininosuccinate synthase (argG), Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH), Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei83Carbamoyl phosphateUniRule annotation1
Binding sitei107Carbamoyl phosphateUniRule annotation1
Binding sitei165OrnithineUniRule annotation1
Binding sitei223OrnithineUniRule annotation1
Binding sitei291Carbamoyl phosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotationSAAS annotationImported
Biological processAmino-acid biosynthesis, Arginine biosynthesisUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00068; UER00112.

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine carbamoyltransferaseUniRule annotationSAAS annotation (EC:2.1.3.3UniRule annotationSAAS annotation)
Short name:
OTCaseUniRule annotation
Gene namesi
Name:argFUniRule annotationImported
Ordered Locus Names:BURPS1106A_0921Imported
OrganismiBurkholderia pseudomallei (strain 1106a)Imported
Taxonomic identifieri357348 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
Proteomesi
  • UP000006738 Componenti: Chromosome I

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliA3NS81.
SMRiA3NS81.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 147OTCace_NInterPro annotationAdd BLAST141
Domaini154 – 301OTCaceInterPro annotationAdd BLAST148

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni56 – 59Carbamoyl phosphate bindingUniRule annotation4
Regioni134 – 137Carbamoyl phosphate bindingUniRule annotation4
Regioni227 – 228Ornithine bindingUniRule annotation2
Regioni263 – 264Carbamoyl phosphate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the ATCase/OTCase family.UniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000022686.
OMAiHPMFLGK.

Family and domain databases

Gene3Di3.40.50.1370. 2 hits.
HAMAPiMF_01109. OTCase. 1 hit.
InterProiView protein in InterPro
IPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
IPR024904. OTCase_ArgI.
PfamiView protein in Pfam
PF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
PRINTSiPR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00658. orni_carb_tr. 1 hit.
PROSITEiView protein in PROSITE
PS00097. CARBAMOYLTRANSFERASE. 1 hit.

Sequencei

Sequence statusi: Complete.

A3NS81-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAKTIRHYL QFKDFSLEDY EYVLERTGIL KRKFKNYETY HPLHDRTLAM
60 70 80 90 100
IFEKSSTRTR LSFEAGIFQL GGHAVFMSTR DTQLGRGEPV EDSAQVISRM
110 120 130 140 150
VDIIMIRTFE QDIIQRFAEN SRVPVINGLT NEYHPCQVLA DIFTYYEHRG
160 170 180 190 200
PIRGKTVAWV GDANNMLYTW IQAARILGFK LRLSTPPGYA LDTKLVDAES
210 220 230 240 250
APFYQVFDDP NEACKGADLV TTDVWTSMGF EAENEARKQA FADWCVDEEM
260 270 280 290 300
MSHAHPDALF MHCLPAHRGE EVTAGVIDGP QSVVWDEAEN RLHVQKALME

FLLLGRLNH
Length:309
Mass (Da):35,418
Last modified:April 3, 2007 - v1
Checksum:iA5868C5D3AD7D582
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000572 Genomic DNA. Translation: ABN92537.1.
RefSeqiWP_004190177.1. NC_009076.1.

Genome annotation databases

EnsemblBacteriaiABN92537; ABN92537; BURPS1106A_0921.
KEGGibpl:BURPS1106A_0921.

Similar proteinsi

Entry informationi

Entry nameiA3NS81_BURP0
AccessioniPrimary (citable) accession number: A3NS81
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: June 7, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported