A3NS57 (KYNB_BURP0) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kynurenine formamidase
Short name=KFA
EC=3.5.1.9

Alternative name(s):
N-formylkynurenine formamidase

Gene names

Name:	kynB
Ordered Locus Names:	BURPS1106A_0897

Organism

Burkholderia pseudomallei (strain 1106a) [Complete proteome] [HAMAP]

Taxonomic identifier

357348 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length	213 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine By similarity.
Catalytic activity	N-formyl-L-kynurenine + H2O = formate + L-kynurenine.
Pathway	Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.
Sequence similarities	Belongs to the kynB family.
Sequence caution	The sequence ABN90793.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Tryptophan catabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	anthranilate metabolic process Inferred from sequence or structural similarity. Source: UniProtKB tryptophan catabolic process to kynurenine Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	arylformamidase activity Inferred from sequence or structural similarity. Source: UniProtKB formamidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 213	213	Kynurenine formamidase		PRO_0000362110

Sequences

	Sequence		Length	Mass (Da)
	A3NS57 [UniParc]. Last modified February 10, 2009. Version 2. Checksum: A0825BE27DD43A27	FASTA	213	22,696
	10 20 30 40 50 60 MDTIWDISPP IAPATPVWPG DTPVGIERVW RIEAGSPVNV ARVTLSPHTG AHADAPLHYD 70 80 90 100 110 120 ADGAPIGAVP LDAYLGRCRV IHCIGARSAV TPEHVRAALA GAPPRVLLRT YGQAPQHAWD 130 140 150 160 170 180 SAFCAVAPET IDLLAAHGVR LVGIDTPSLD PQESKTMDAH RRIRAHRMAI LEGLVLDEIA 190 200 210 AGDYELIALP LKFATLDASP VRAVLRALPD APR

References

[1]	DeShazer D., Woods D.E., Nierman W.C. Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1106a.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000572 Genomic DNA. Translation: ABN90793.1. Different initiation.
RefSeq	YP_001065178.1. NC_009076.1.
3D structure databases
ProteinModelPortal	A3NS57.
ModBase	Search...
Protein-protein interaction databases
STRING	A3NS57.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4900765.
GenomeReviews	Gene locus BURPS1106A_0897 in contig CP000572_GR.
KEGG	bpl:BURPS1106A_0897.
PATRIC	19220350. VBIBurPse14980_0859.
TIGR	BURPS1106A_0897.
Phylogenomic databases
eggNOG	COG1878.
HOGENOM	HBG686791.
ProtClustDB	CLSK930430.
Family and domain databases
InterPro	IPR017484. Arylformamidase. IPR007325. Cyclase. [Graphical view]
KO	K07130.
Pfam	PF04199. Cyclase. 1 hit. [Graphical view]
TIGRFAMs	TIGR03035. Trp_arylform. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KYNB_BURP0

Accession

Primary (citable) accession number: A3NS57

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	February 10, 2009
Last modified:	December 14, 2011
This is version 28 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program