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A3NKP8

- BETB_BURP6

UniProt

A3NKP8 - BETB_BURP6

Protein

NAD/NADP-dependent betaine aldehyde dehydrogenase

Gene

betB

Organism
Burkholderia pseudomallei (strain 668)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (03 Apr 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid.UniRule annotation

    Catalytic activityi

    Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

    Cofactori

    Binds 2 potassium ions per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi26 – 261Potassium 1UniRule annotation
    Metal bindingi93 – 931Potassium 1UniRule annotation
    Active sitei162 – 1621Charge relay systemUniRule annotation
    Metal bindingi180 – 1801Potassium 1; via carbonyl oxygenUniRule annotation
    Binding sitei209 – 2091NAD/NADP; via amide nitrogenUniRule annotation
    Metal bindingi245 – 2451Potassium 2; via carbonyl oxygenUniRule annotation
    Sitei247 – 2471Seems to be a necessary countercharge to the potassium cationsUniRule annotation
    Active sitei251 – 2511Proton acceptorUniRule annotation
    Binding sitei285 – 2851NAD/NADPUniRule annotation
    Binding sitei386 – 3861NAD/NADPUniRule annotation
    Metal bindingi456 – 4561Potassium 2; via carbonyl oxygenUniRule annotation
    Metal bindingi459 – 4591Potassium 2; via carbonyl oxygenUniRule annotation
    Active sitei463 – 4631Charge relay systemUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi150 – 1534NAD/NADPUniRule annotation
    Nucleotide bindingi176 – 1794NAD/NADPUniRule annotation
    Nucleotide bindingi228 – 2336NAD/NADPUniRule annotation

    GO - Molecular functioni

    1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Metal-binding, NAD, NADP, Potassium

    Enzyme and pathway databases

    BioCyciBPSE320373:GJ9C-5862-MONOMER.
    UniPathwayiUPA00529; UER00386.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD/NADP-dependent betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
    Short name:
    BADHUniRule annotation
    Gene namesi
    Name:betBUniRule annotation
    Ordered Locus Names:BURPS668_A1924
    OrganismiBurkholderia pseudomallei (strain 668)
    Taxonomic identifieri320373 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
    ProteomesiUP000002153: Chromosome II

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 489489NAD/NADP-dependent betaine aldehyde dehydrogenasePRO_1000047039Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei285 – 2851Cysteine sulfenic acid (-SOH)UniRule annotation

    Keywords - PTMi

    Oxidation

    Interactioni

    Subunit structurei

    Dimer of dimers.UniRule annotation

    Protein-protein interaction databases

    STRINGi320373.BURPS668_A1924.

    Structurei

    3D structure databases

    ProteinModelPortaliA3NKP8.
    SMRiA3NKP8. Positions 8-489.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1012.
    HOGENOMiHOG000271505.
    KOiK00130.
    OMAiSIFEARW.
    OrthoDBiEOG6BS8QW.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    HAMAPiMF_00804. BADH.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR011264. BADH.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR01804. BADH. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A3NKP8-1 [UniParc]FASTAAdd to Basket

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    MSVYGLQRLY IAGAHADATS GKTFDTFDPA TGELLARVQQ ASADDVDRAV    50
    ASAREGQREW AAMTAMQRSR ILRRAVELLR ERNNALAELE MRDTGKPIAE 100
    TRAVDIVTGA DVIEYYAGLA TAIEGLQVPL RPESFVYTRR EPLGVCAGIG 150
    AWNYPIQIAC WKSAPALAAG NAMIFKPSEV TPLSALKLAE IYTEAGVPAG 200
    VFNVVQGDGS VGALLSAHPG IAKVSFTGGV ETGKKVMSLA GASSLKEVTM 250
    ELGGKSPLIV FDDADLDRAA DIAVTANFFS AGQVCTNGTR VFVQQAVKDA 300
    FVERVLARVA RIRAGKPSDP DTNFGPLASA AQLDKVLGYI DSGKAEGAKL 350
    LAGGARLVND HFASGQYVAP TVFGDCRDDM RIVREEIFGP VMSILSFETE 400
    DEAIARANAT DYGLAAGVVT ENLSRAHRAI HRLEAGICWI NTWGESPAEM 450
    PVGGYKQSGV GRENGITTLE HYTRIKSVQV ELGRYQPVF 489
    Length:489
    Mass (Da):52,172
    Last modified:April 3, 2007 - v1
    Checksum:iB4CCEB7C82D3EEC5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000571 Genomic DNA. Translation: ABN86741.1.
    RefSeqiWP_011853337.1. NC_009075.1.
    YP_001062919.1. NC_009075.1.

    Genome annotation databases

    EnsemblBacteriaiABN86741; ABN86741; BURPS668_A1924.
    GeneIDi4886363.
    KEGGibpd:BURPS668_A1924.
    PATRICi19257047. VBIBurPse82117_5428.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000571 Genomic DNA. Translation: ABN86741.1 .
    RefSeqi WP_011853337.1. NC_009075.1.
    YP_001062919.1. NC_009075.1.

    3D structure databases

    ProteinModelPortali A3NKP8.
    SMRi A3NKP8. Positions 8-489.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 320373.BURPS668_A1924.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABN86741 ; ABN86741 ; BURPS668_A1924 .
    GeneIDi 4886363.
    KEGGi bpd:BURPS668_A1924.
    PATRICi 19257047. VBIBurPse82117_5428.

    Phylogenomic databases

    eggNOGi COG1012.
    HOGENOMi HOG000271505.
    KOi K00130.
    OMAi SIFEARW.
    OrthoDBi EOG6BS8QW.

    Enzyme and pathway databases

    UniPathwayi UPA00529 ; UER00386 .
    BioCyci BPSE320373:GJ9C-5862-MONOMER.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    HAMAPi MF_00804. BADH.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR011264. BADH.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR01804. BADH. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. DeShazer D., Woods D.E., Nierman W.C.
      Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 668.

    Entry informationi

    Entry nameiBETB_BURP6
    AccessioniPrimary (citable) accession number: A3NKP8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3