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A3NJS6 (THIM_BURP6) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name=TH kinase
Short name=Thz kinase
Gene names
Name:thiM
Ordered Locus Names:BURPS668_A1601
OrganismBurkholderia pseudomallei (strain 668) [Complete proteome] [HAMAP]
Taxonomic identifier320373 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group

Protein attributes

Sequence length276 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence caution

The sequence ABN86382.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 276276Hydroxyethylthiazole kinase HAMAP-Rule MF_00228
PRO_0000383829

Sites

Binding site1261ATP By similarity
Binding site1721ATP By similarity
Binding site1991Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
A3NJS6 [UniParc].

Last modified September 22, 2009. Version 2.
Checksum: 1F7B2E4B381E6D6E

FASTA27627,510
        10         20         30         40         50         60 
MESISWNTPS VRDALAAVKR DAPFVYGLTN YVAANLSANV LLAVGAAPAI GAAADWPARF 

        70         80         90        100        110        120 
GAGANALWIN TAALMSSGAD TLLTAARAAS KAGTRWVLDP VALGAGAPEY DAIVRDLLAL 

       130        140        150        160        170        180 
RPTVIRGNAS ELIALAGGTA AGKGVDTTAS PESALAFIGD LARRSGAVVA VSGPTDYVTD 

       190        200        210        220        230        240 
GVATLAVAGG DARLTRVTGA GCALGALIAA LLAQRGAALA AASAAHAIYA TAAERAADAR 

       250        260        270 
GTASFAVRFV DELSLLDPAE SSRDRSAGQI GAKRRE 

« Hide

References

[1]DeShazer D., Woods D.E., Nierman W.C.
Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 668.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000571 Genomic DNA. Translation: ABN86382.1. Different initiation.
RefSeqYP_001062597.1. NC_009075.1.

3D structure databases

ProteinModelPortalA3NJS6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING320373.BURPS668_A1601.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABN86382; ABN86382; BURPS668_A1601.
GeneID4886592.
KEGGbpd:BURPS668_A1601.
PATRIC19256465. VBIBurPse82117_5137.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2145.
HOGENOMHOG000114352.
KOK00878.
OrthoDBEOG6677TX.

Enzyme and pathway databases

BioCycBPSE320373:GJ9C-5551-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

Gene3D3.40.1190.20. 1 hit.
HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
SUPFAMSSF53613. SSF53613. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTHIM_BURP6
AccessionPrimary (citable) accession number: A3NJS6
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 22, 2009
Last modified: June 11, 2014
This is version 49 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways