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A3NI75

- A3NI75_BURP6

UniProt

A3NI75 - A3NI75_BURP6

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Protein
Alanine racemase
Gene
alr, BURPS668_A1047
Organism
Burkholderia pseudomallei (strain 668)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotations

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei35 – 351Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei130 – 1301Substrate By similarityUniRule annotation
Active sitei252 – 2521Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei300 – 3001Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotationsImported

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciBPSE320373:GJ9C-5018-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:BURPS668_A1047Imported
OrganismiBurkholderia pseudomallei (strain 668)Imported
Taxonomic identifieri320373 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
ProteomesiUP000002153: Chromosome II

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei35 – 351N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi320373.BURPS668_A1047.

Structurei

3D structure databases

ProteinModelPortaliA3NI75.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031446.
KOiK01775.
OMAiISHFACA.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3NI75-1 [UniParc]FASTAAdd to Basket

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MPRPIVARIH PDAVAHNLAI VRQKAPNARI WSVVKANAYG HGIEHVYPAL    50
AGADGIALLD LDEAVRVREL GWTKPVLLLE GIFEAADVEI ADRHRLTVAV 100
HGDEQLKLLT AAKTTRPIDI QLKMNSGMNR LGYRPHALRA AWERAAAAPS 150
IGRIALMMHF ANADEGEIDW QMSVFDAATQ GLPGERTLSN SAAVLWHPRA 200
HRDWVRPGTI LYGASPTGAS RHVADVPLRA AMTVTSRIIG VQTLTPGETV 250
GYGRCFAAER EMRIGVVACG YADGYPRHAP TGTPIAVDGV RTQVVGRVSM 300
DMLTVDLTPC PNAGVGSAVE LWGEQVRVDD VAEAAGTIGY ELMCALARRV 350
PVTVDPSPAA AALARPVRTG SYGR 374
Length:374
Mass (Da):40,088
Last modified:April 3, 2007 - v1
Checksum:i8BD07162169C70F3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000571 Genomic DNA. Translation: ABN87855.1.
RefSeqiYP_001062046.1. NC_009075.1.

Genome annotation databases

EnsemblBacteriaiABN87855; ABN87855; BURPS668_A1047.
GeneIDi4887080.
KEGGibpd:BURPS668_A1047.
PATRICi19255477. VBIBurPse82117_4644.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000571 Genomic DNA. Translation: ABN87855.1 .
RefSeqi YP_001062046.1. NC_009075.1.

3D structure databases

ProteinModelPortali A3NI75.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 320373.BURPS668_A1047.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABN87855 ; ABN87855 ; BURPS668_A1047 .
GeneIDi 4887080.
KEGGi bpd:BURPS668_A1047.
PATRICi 19255477. VBIBurPse82117_4644.

Phylogenomic databases

eggNOGi COG0787.
HOGENOMi HOG000031446.
KOi K01775.
OMAi ISHFACA.
OrthoDBi EOG6PP9NJ.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci BPSE320373:GJ9C-5018-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. DeShazer D., Woods D.E., Nierman W.C.
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 668Imported.

Entry informationi

Entry nameiA3NI75_BURP6
AccessioniPrimary (citable) accession number: A3NI75
Entry historyi
Integrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: July 9, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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