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Protein

Alanine racemase

Gene

alr

Organism
Burkholderia pseudomallei (strain 668)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei35 – 351Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei130 – 1301SubstrateUniRule annotation
Active sitei252 – 2521Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei300 – 3001Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciBPSE320373:GJ9C-5018-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotationSAAS annotation (EC:5.1.1.1UniRule annotationSAAS annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:BURPS668_A1047Imported
OrganismiBurkholderia pseudomallei (strain 668)Imported
Taxonomic identifieri320373 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
ProteomesiUP000002153: Chromosome II

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei35 – 351N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi320373.BURPS668_A1047.

Structurei

3D structure databases

ProteinModelPortaliA3NI75.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031446.
KOiK01775.
OMAiSVELWGD.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3NI75-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPRPIVARIH PDAVAHNLAI VRQKAPNARI WSVVKANAYG HGIEHVYPAL
60 70 80 90 100
AGADGIALLD LDEAVRVREL GWTKPVLLLE GIFEAADVEI ADRHRLTVAV
110 120 130 140 150
HGDEQLKLLT AAKTTRPIDI QLKMNSGMNR LGYRPHALRA AWERAAAAPS
160 170 180 190 200
IGRIALMMHF ANADEGEIDW QMSVFDAATQ GLPGERTLSN SAAVLWHPRA
210 220 230 240 250
HRDWVRPGTI LYGASPTGAS RHVADVPLRA AMTVTSRIIG VQTLTPGETV
260 270 280 290 300
GYGRCFAAER EMRIGVVACG YADGYPRHAP TGTPIAVDGV RTQVVGRVSM
310 320 330 340 350
DMLTVDLTPC PNAGVGSAVE LWGEQVRVDD VAEAAGTIGY ELMCALARRV
360 370
PVTVDPSPAA AALARPVRTG SYGR
Length:374
Mass (Da):40,088
Last modified:April 3, 2007 - v1
Checksum:i8BD07162169C70F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000571 Genomic DNA. Translation: ABN87855.1.
RefSeqiYP_001062046.1. NC_009075.1.

Genome annotation databases

EnsemblBacteriaiABN87855; ABN87855; BURPS668_A1047.
GeneIDi4887080.
KEGGibpd:BURPS668_A1047.
PATRICi19255477. VBIBurPse82117_4644.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000571 Genomic DNA. Translation: ABN87855.1.
RefSeqiYP_001062046.1. NC_009075.1.

3D structure databases

ProteinModelPortaliA3NI75.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi320373.BURPS668_A1047.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABN87855; ABN87855; BURPS668_A1047.
GeneIDi4887080.
KEGGibpd:BURPS668_A1047.
PATRICi19255477. VBIBurPse82117_4644.

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031446.
KOiK01775.
OMAiSVELWGD.
OrthoDBiEOG6PP9NJ.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciBPSE320373:GJ9C-5018-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. DeShazer D., Woods D.E., Nierman W.C.
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 668Imported.

Entry informationi

Entry nameiA3NI75_BURP6
AccessioniPrimary (citable) accession number: A3NI75
Entry historyi
Integrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: February 4, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.