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A3NED2 (AROB_BURP6) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:BURPS668_3699
OrganismBurkholderia pseudomallei (strain 668) [Complete proteome] [HAMAP]
Taxonomic identifier320373 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

Divalent metal cations By similarity. HAMAP MF_00110

NAD By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm By similarity HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3593593-dehydroquinate synthase HAMAP MF_00110
PRO_1000094479

Sequences

Sequence LengthMass (Da)Tools
A3NED2 [UniParc].

Last modified April 3, 2007. Version 1.
Checksum: CFD37136057BD086

FASTA35937,896
        10         20         30         40         50         60 
MITVNVDLGE RAYPIHIGAD LIGRTELFAP HIAGASVTIV TNTTVEPLYG DTLRAALAPL 

        70         80         90        100        110        120 
GKRVSTVVLP DGEAYKNWET LNLIFDGLLE QHADRKTTLI ALGGGVIGDM TGFAAACYMR 

       130        140        150        160        170        180 
GVPFIQVPTT LLSQVDSSVG GKTGINHPLG KNMIGAFYQP QAVIADIGAL STLPDRELAA 

       190        200        210        220        230        240 
GVAEIVKTGA IADAAFFDWI EANVGALTRR DPDALAHAVK RSCEIKAGVV AADEREGGLR 

       250        260        270        280        290        300 
AILNFGHTFG HAIEAGLGYG EWLHGEAVGC GMVMAADLSV RTGHLDEASR ARLCRVVEAA 

       310        320        330        340        350 
HLPTRAPDLG DARYVELMRV DKKAEAGAIK FILLKRFGET IITPAPDDAV LATLAATTR

« Hide

References

[1]DeShazer D., Woods D.E., Nierman W.C.
Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 668.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000570 Genomic DNA. Translation: ABN84390.1.
RefSeqYP_001060703.1. NC_009074.1.

3D structure databases

ProteinModelPortalA3NED2.
ModBaseSearch...

Protein-protein interaction databases

STRINGA3NED2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4881745.
GenomeReviewsGene locus BURPS668_3699 in contig CP000570_GR.
KEGGbpd:BURPS668_3699.
PATRIC19253026. VBIBurPse82117_3438.
TIGRBURPS668_3699.

Phylogenomic databases

eggNOGCOG0337.
HOGENOMHBG632303.
OMAVMALEMS.
ProtClustDBPRK00002.

Enzyme and pathway databases

BioCycBPSE320373:BURPS668_3699-MONOMER.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_BURP6
AccessionPrimary (citable) accession number: A3NED2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 3, 2007
Last modified: December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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