A3NDZ3 (TRPC_BURP6) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Indole-3-glycerol phosphate synthase
Short name=IGPS
EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	BURPS668_3559

Organism

Burkholderia pseudomallei (strain 668) [Complete proteome] [HAMAP]

Taxonomic identifier

320373 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length	261 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134_B
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134_B
Sequence similarities	Belongs to the TrpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 261	261	Indole-3-glycerol phosphate synthase HAMAP MF_00134_B		PRO_1000018460

Sequences

	Sequence		Length	Mass (Da)
	A3NDZ3 [UniParc]. Last modified April 3, 2007. Version 1. Checksum: EE4A56EA4E3DD7C9	FASTA	261	28,335
	10 20 30 40 50 60 MSDILDKIIA VKREEIAAAL ESAPLEELKV QASARDSRDF VGALRDKHAA GHAAVIAEVK 70 80 90 100 110 120 KASPSKGVLR EHFVPADIAR SYAQHGAACL SVLTDERFFQ GSARYLEQAR AACALPVLRK 130 140 150 160 170 180 DFIVDAYQVL EARAMGADAI LLIAAALDTP LMIDLEAYAH SLGLAVLVEV HNRSELDEAL 190 200 210 220 230 240 KLKTPLVGIN NRNLRTFETT IDTTLGMLDA IPDDRIVVTE SGILSRADVE RMEAAGVHTF 250 260 LVGEAFMRAE NPGAELARMF F

References

[1]	DeShazer D., Woods D.E., Nierman W.C. Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 668.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000570 Genomic DNA. Translation: ABN83518.1.
RefSeq	YP_001060564.1. NC_009074.1.
3D structure databases
ProteinModelPortal	A3NDZ3.
ModBase	Search...
Protein-protein interaction databases
STRING	A3NDZ3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4885202.
GenomeReviews	Gene locus BURPS668_3559 in contig CP000570_GR.
KEGG	bpd:BURPS668_3559.
NMPDR	fig|320373.3.peg.2545.
PATRIC	19252760. VBIBurPse82117_3306.
TIGR	BURPS668_3559.
Phylogenomic databases
eggNOG	COG0134.
HOGENOM	HBG540956.
OMA	LEYAVPH.
ProtClustDB	PRK00278.
Enzyme and pathway databases
BioCyc	BPSE320373:BURPS668_3559-MONOMER.
Family and domain databases
HAMAP	MF_00134_B. IGPS_B. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01609.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_BURP6

Accession

Primary (citable) accession number: A3NDZ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	April 3, 2007
Last modified:	December 14, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program