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A3NAT4

- LPXB_BURP6

UniProt

A3NAT4 - LPXB_BURP6

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Burkholderia pseudomallei (strain 668)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciBPSE320373:GJ9C-2417-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:BURPS668_2423
    OrganismiBurkholderia pseudomallei (strain 668)
    Taxonomic identifieri320373 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
    ProteomesiUP000002153: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 388388Lipid-A-disaccharide synthasePRO_1000049391Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi320373.BURPS668_2423.

    Structurei

    3D structure databases

    ProteinModelPortaliA3NAT4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018003.
    KOiK00748.
    OMAiVSPITYR.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A3NAT4-1 [UniParc]FASTAAdd to Basket

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    MAFQLTPLRV ALVAGEPSGD LLGASLLGGL HARLPASSRY YGIGGPRMSA    50
    VEFDAHWPME KLAVRGYVEA LKHIPEILRI RGELKRQLLA EPPDAFVGID 100
    APDFNFGLEQ ALRGAGIPTI HFVCPSIWAW RGGRIKKIVK AVDHMLCLFP 150
    FEPELLEKAG VAATFVGHPL ADEIPLAPDT HGARIALGLP GGGPVIAVLP 200
    GSRRSEIELI GPTFFDAMEL MQQREPGVRF VVPAATPALR ALLQPLVDAH 250
    PSLSVTLTEG RAQVAMTAAD AILVKSGTVT LEAALLKKPM VISYKVPWLT 300
    GQIMRRQGYL PYVGLPNILA GRFVVPELLQ HFATPDALAD ATLTQLRDDA 350
    NRRALTDIFT DMHLALRQNT AQRAAEAVAR VIDSRKPR 388
    Length:388
    Mass (Da):42,003
    Last modified:April 3, 2007 - v1
    Checksum:i0546E47CAF98A772
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000570 Genomic DNA. Translation: ABN83057.1.
    RefSeqiWP_011851815.1. NC_009074.1.
    YP_001059455.1. NC_009074.1.

    Genome annotation databases

    EnsemblBacteriaiABN83057; ABN83057; BURPS668_2423.
    GeneIDi4881778.
    KEGGibpd:BURPS668_2423.
    PATRICi19250619. VBIBurPse82117_2262.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000570 Genomic DNA. Translation: ABN83057.1 .
    RefSeqi WP_011851815.1. NC_009074.1.
    YP_001059455.1. NC_009074.1.

    3D structure databases

    ProteinModelPortali A3NAT4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 320373.BURPS668_2423.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABN83057 ; ABN83057 ; BURPS668_2423 .
    GeneIDi 4881778.
    KEGGi bpd:BURPS668_2423.
    PATRICi 19250619. VBIBurPse82117_2262.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018003.
    KOi K00748.
    OMAi VSPITYR.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci BPSE320373:GJ9C-2417-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. DeShazer D., Woods D.E., Nierman W.C.
      Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 668.

    Entry informationi

    Entry nameiLPXB_BURP6
    AccessioniPrimary (citable) accession number: A3NAT4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3