Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein-L-isoaspartate O-methyltransferase

Gene

pcm

Organism
Burkholderia pseudomallei (strain 668)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + protein L-isoaspartate = S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei170UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-L-isoaspartate O-methyltransferaseUniRule annotation (EC:2.1.1.77UniRule annotation)
Alternative name(s):
L-isoaspartyl protein carboxyl methyltransferaseUniRule annotation
Protein L-isoaspartyl methyltransferaseUniRule annotation
Protein-beta-aspartate methyltransferaseUniRule annotation
Short name:
PIMTUniRule annotation
Gene namesi
Name:pcmUniRule annotation
Ordered Locus Names:BURPS668_2200
OrganismiBurkholderia pseudomallei (strain 668)
Taxonomic identifieri320373 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
Proteomesi
  • UP000002153 Componenti: Chromosome I

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003518371 – 322Protein-L-isoaspartate O-methyltransferaseAdd BLAST322

Structurei

3D structure databases

ProteinModelPortaliA3NA64.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000257189.
KOiK00573.
OMAiAWMSSGK.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00090. PIMT. 1 hit.
InterProiIPR000682. PCMT.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR11579. PTHR11579. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00080. pimt. 1 hit.
PROSITEiPS01279. PCMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3NA64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGERAKRFP LALEDLKREP RKPEGRVAER QAAGDAARQR LTAAAAVPAA
60 70 80 90 100
ASPIVPERRA PHGGVFAANP ARAKQHAPAA PGAAKRAPQG GAKQGDRSAA
110 120 130 140 150
PNVALSGALA LTSERVRERM VERLRANGVA DPRVLAAMSA VPRHMFVDPG
160 170 180 190 200
LAAQAYEDAA LPIGHQQTIS KPSVVARMIE LAAAGRALER VLEIGTGCGY
210 220 230 240 250
QAAVLSRVAR DVYSIERVKP LYERAKLNLR PLRVPNIRLH YGDGRVGLPA
260 270 280 290 300
AAPFDAIVIA AAGLDVPRAL LEQLAIGGRL VAPVGEQAGE QVLTLVERVA
310 320
PAQWRESRLD RVFFVPLKSG VI
Length:322
Mass (Da):34,143
Last modified:April 3, 2007 - v1
Checksum:i0104B9ECAB484FA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000570 Genomic DNA. Translation: ABN81508.1.
RefSeqiWP_011851736.1. NC_009074.1.

Genome annotation databases

EnsemblBacteriaiABN81508; ABN81508; BURPS668_2200.
KEGGibpd:BURPS668_2200.
PATRICi19250202. VBIBurPse82117_2057.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000570 Genomic DNA. Translation: ABN81508.1.
RefSeqiWP_011851736.1. NC_009074.1.

3D structure databases

ProteinModelPortaliA3NA64.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABN81508; ABN81508; BURPS668_2200.
KEGGibpd:BURPS668_2200.
PATRICi19250202. VBIBurPse82117_2057.

Phylogenomic databases

HOGENOMiHOG000257189.
KOiK00573.
OMAiAWMSSGK.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00090. PIMT. 1 hit.
InterProiIPR000682. PCMT.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR11579. PTHR11579. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00080. pimt. 1 hit.
PROSITEiPS01279. PCMT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPIMT_BURP6
AccessioniPrimary (citable) accession number: A3NA64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: April 3, 2007
Last modified: November 2, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.