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A3N925

- PYRD_BURP6

UniProt

A3N925 - PYRD_BURP6

Protein

Dihydroorotate dehydrogenase (quinone)

Gene

pyrD

Organism
Burkholderia pseudomallei (strain 668)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (03 Apr 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.UniRule annotation

    Catalytic activityi

    (S)-dihydroorotate + a quinone = orotate + a quinol.UniRule annotation

    Cofactori

    Binds 1 FMN per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei69 – 691SubstrateUniRule annotation
    Binding sitei89 – 891FMN; via amide nitrogenUniRule annotation
    Binding sitei142 – 1421FMNUniRule annotation
    Binding sitei175 – 1751FMNUniRule annotation
    Binding sitei175 – 1751SubstrateUniRule annotation
    Active sitei178 – 1781NucleophileUniRule annotation
    Binding sitei180 – 1801SubstrateUniRule annotation
    Binding sitei220 – 2201FMNUniRule annotation
    Binding sitei248 – 2481FMN; via carbonyl oxygenUniRule annotation
    Binding sitei271 – 2711FMN; via amide nitrogenUniRule annotation
    Binding sitei300 – 3001FMN; via amide nitrogenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 695FMNUniRule annotation
    Nucleotide bindingi321 – 3222FMNUniRule annotation

    GO - Molecular functioni

    1. dihydroorotate oxidase activity Source: InterPro

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Keywords - Ligandi

    Flavoprotein, FMN

    Enzyme and pathway databases

    BioCyciBPSE320373:GJ9C-1806-MONOMER.
    UniPathwayiUPA00070; UER00946.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dihydroorotate dehydrogenase (quinone)UniRule annotation (EC:1.3.5.2UniRule annotation)
    Alternative name(s):
    DHOdehaseUniRule annotation
    Short name:
    DHODUniRule annotation
    Short name:
    DHODaseUniRule annotation
    Dihydroorotate oxidaseUniRule annotation
    Gene namesi
    Name:pyrDUniRule annotation
    Ordered Locus Names:BURPS668_1809
    OrganismiBurkholderia pseudomallei (strain 668)
    Taxonomic identifieri320373 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
    ProteomesiUP000002153: Chromosome I

    Subcellular locationi

    Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation

    GO - Cellular componenti

    1. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 342342Dihydroorotate dehydrogenase (quinone)PRO_1000024163Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi320373.BURPS668_1809.

    Structurei

    3D structure databases

    ProteinModelPortaliA3N925.
    SMRiA3N925. Positions 5-339.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni114 – 1185Substrate bindingUniRule annotation
    Regioni249 – 2502Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0167.
    HOGENOMiHOG000225103.
    KOiK00254.
    OMAiGECIDAF.
    OrthoDBiEOG65BDN8.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00225. DHO_dh_type2.
    InterProiIPR013785. Aldolase_TIM.
    IPR012135. Dihydroorotate_DH_1_2.
    IPR005719. Dihydroorotate_DH_2.
    IPR001295. Dihydroorotate_DH_CS.
    [Graphical view]
    PfamiPF01180. DHO_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000164. DHO_oxidase. 1 hit.
    TIGRFAMsiTIGR01036. pyrD_sub2. 1 hit.
    PROSITEiPS00911. DHODEHASE_1. 1 hit.
    PS00912. DHODEHASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A3N925-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFSSLYPLAR ASLFKMDAED AHHLTLRMLG AAGRTGLACA LSPRVPDAPR    50
    TVMGLSFRNP VGLAAGLDKD GAAIDGFAAL GFGFIEVGTV TPRAQPGNPR 100
    PRLFRLPEAD AIINRMGFNN SGVDQFVKNV QAARYRGVLG LNIGKNADTP 150
    IERAADDYLY CLERVYPFAS YVTINISSPN TKNLRQLQGA GELDALLAAL 200
    KDKQRRLADL HGKLVPLALK IAPDLDDEQV KEIAATLLRH DIEGVIATNT 250
    TLSREAVKGL PHADEAGGLS GRPVFDASNA VIRKLRAELG DAVPIIGVGG 300
    IFSGEDARAK LAAGAALVQL YTGFIYRGPA LVAECVKAIA RG 342
    Length:342
    Mass (Da):36,305
    Last modified:April 3, 2007 - v1
    Checksum:i5E7244A6476813E7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000570 Genomic DNA. Translation: ABN82176.1.
    RefSeqiWP_011851553.1. NC_009074.1.
    YP_001058846.1. NC_009074.1.

    Genome annotation databases

    EnsemblBacteriaiABN82176; ABN82176; BURPS668_1809.
    GeneIDi4881949.
    KEGGibpd:BURPS668_1809.
    PATRICi19249485. VBIBurPse82117_1701.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000570 Genomic DNA. Translation: ABN82176.1 .
    RefSeqi WP_011851553.1. NC_009074.1.
    YP_001058846.1. NC_009074.1.

    3D structure databases

    ProteinModelPortali A3N925.
    SMRi A3N925. Positions 5-339.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 320373.BURPS668_1809.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABN82176 ; ABN82176 ; BURPS668_1809 .
    GeneIDi 4881949.
    KEGGi bpd:BURPS668_1809.
    PATRICi 19249485. VBIBurPse82117_1701.

    Phylogenomic databases

    eggNOGi COG0167.
    HOGENOMi HOG000225103.
    KOi K00254.
    OMAi GECIDAF.
    OrthoDBi EOG65BDN8.

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00946 .
    BioCyci BPSE320373:GJ9C-1806-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00225. DHO_dh_type2.
    InterProi IPR013785. Aldolase_TIM.
    IPR012135. Dihydroorotate_DH_1_2.
    IPR005719. Dihydroorotate_DH_2.
    IPR001295. Dihydroorotate_DH_CS.
    [Graphical view ]
    Pfami PF01180. DHO_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000164. DHO_oxidase. 1 hit.
    TIGRFAMsi TIGR01036. pyrD_sub2. 1 hit.
    PROSITEi PS00911. DHODEHASE_1. 1 hit.
    PS00912. DHODEHASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. DeShazer D., Woods D.E., Nierman W.C.
      Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 668.

    Entry informationi

    Entry nameiPYRD_BURP6
    AccessioniPrimary (citable) accession number: A3N925
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3