SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A3N925

- PYRD_BURP6

UniProt

A3N925 - PYRD_BURP6

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Dihydroorotate dehydrogenase (quinone)

Gene
pyrD, BURPS668_1809
Organism
Burkholderia pseudomallei (strain 668)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor By similarity.UniRule annotation

Catalytic activityi

(S)-dihydroorotate + a quinone = orotate + a quinol.UniRule annotation

Cofactori

Binds 1 FMN per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei69 – 691Substrate By similarity
Binding sitei89 – 891FMN; via amide nitrogen By similarity
Binding sitei142 – 1421FMN By similarity
Binding sitei175 – 1751FMN By similarity
Binding sitei175 – 1751Substrate By similarity
Active sitei178 – 1781Nucleophile By similarity
Binding sitei180 – 1801Substrate By similarity
Binding sitei220 – 2201FMN By similarity
Binding sitei248 – 2481FMN; via carbonyl oxygen By similarity
Binding sitei271 – 2711FMN; via amide nitrogen By similarity
Binding sitei300 – 3001FMN; via amide nitrogen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 695FMN By similarity
Nucleotide bindingi321 – 3222FMN By similarity

GO - Molecular functioni

  1. dihydroorotate oxidase activity Source: InterPro

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyrimidine biosynthesis

Keywords - Ligandi

Flavoprotein, FMN

Enzyme and pathway databases

BioCyciBPSE320373:GJ9C-1806-MONOMER.
UniPathwayiUPA00070; UER00946.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydroorotate dehydrogenase (quinone) (EC:1.3.5.2)
Alternative name(s):
DHOdehase
Short name:
DHOD
Short name:
DHODase
Dihydroorotate oxidase
Gene namesi
Name:pyrD
Ordered Locus Names:BURPS668_1809
OrganismiBurkholderia pseudomallei (strain 668)
Taxonomic identifieri320373 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
ProteomesiUP000002153: Chromosome I

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 342342Dihydroorotate dehydrogenase (quinone)UniRule annotationPRO_1000024163Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi320373.BURPS668_1809.

Structurei

3D structure databases

ProteinModelPortaliA3N925.
SMRiA3N925. Positions 5-339.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni114 – 1185Substrate binding By similarity
Regioni249 – 2502Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0167.
HOGENOMiHOG000225103.
KOiK00254.
OMAiGECIDAF.
OrthoDBiEOG65BDN8.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00225. DHO_dh_type2.
InterProiIPR013785. Aldolase_TIM.
IPR012135. Dihydroorotate_DH_1_2.
IPR005719. Dihydroorotate_DH_2.
IPR001295. Dihydroorotate_DH_CS.
[Graphical view]
PfamiPF01180. DHO_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000164. DHO_oxidase. 1 hit.
TIGRFAMsiTIGR01036. pyrD_sub2. 1 hit.
PROSITEiPS00911. DHODEHASE_1. 1 hit.
PS00912. DHODEHASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3N925-1 [UniParc]FASTAAdd to Basket

« Hide

MFSSLYPLAR ASLFKMDAED AHHLTLRMLG AAGRTGLACA LSPRVPDAPR    50
TVMGLSFRNP VGLAAGLDKD GAAIDGFAAL GFGFIEVGTV TPRAQPGNPR 100
PRLFRLPEAD AIINRMGFNN SGVDQFVKNV QAARYRGVLG LNIGKNADTP 150
IERAADDYLY CLERVYPFAS YVTINISSPN TKNLRQLQGA GELDALLAAL 200
KDKQRRLADL HGKLVPLALK IAPDLDDEQV KEIAATLLRH DIEGVIATNT 250
TLSREAVKGL PHADEAGGLS GRPVFDASNA VIRKLRAELG DAVPIIGVGG 300
IFSGEDARAK LAAGAALVQL YTGFIYRGPA LVAECVKAIA RG 342
Length:342
Mass (Da):36,305
Last modified:April 3, 2007 - v1
Checksum:i5E7244A6476813E7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000570 Genomic DNA. Translation: ABN82176.1.
RefSeqiWP_011851553.1. NC_009074.1.
YP_001058846.1. NC_009074.1.

Genome annotation databases

EnsemblBacteriaiABN82176; ABN82176; BURPS668_1809.
GeneIDi4881949.
KEGGibpd:BURPS668_1809.
PATRICi19249485. VBIBurPse82117_1701.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000570 Genomic DNA. Translation: ABN82176.1 .
RefSeqi WP_011851553.1. NC_009074.1.
YP_001058846.1. NC_009074.1.

3D structure databases

ProteinModelPortali A3N925.
SMRi A3N925. Positions 5-339.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 320373.BURPS668_1809.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABN82176 ; ABN82176 ; BURPS668_1809 .
GeneIDi 4881949.
KEGGi bpd:BURPS668_1809.
PATRICi 19249485. VBIBurPse82117_1701.

Phylogenomic databases

eggNOGi COG0167.
HOGENOMi HOG000225103.
KOi K00254.
OMAi GECIDAF.
OrthoDBi EOG65BDN8.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00946 .
BioCyci BPSE320373:GJ9C-1806-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00225. DHO_dh_type2.
InterProi IPR013785. Aldolase_TIM.
IPR012135. Dihydroorotate_DH_1_2.
IPR005719. Dihydroorotate_DH_2.
IPR001295. Dihydroorotate_DH_CS.
[Graphical view ]
Pfami PF01180. DHO_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000164. DHO_oxidase. 1 hit.
TIGRFAMsi TIGR01036. pyrD_sub2. 1 hit.
PROSITEi PS00911. DHODEHASE_1. 1 hit.
PS00912. DHODEHASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. DeShazer D., Woods D.E., Nierman W.C.
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 668.

Entry informationi

Entry nameiPYRD_BURP6
AccessioniPrimary (citable) accession number: A3N925
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: September 3, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi