Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A3N700

- HEM3_BURP6

UniProt

A3N700 - HEM3_BURP6

Protein

Porphobilinogen deaminase

Gene

hemC

Organism
Burkholderia pseudomallei (strain 668)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (03 Apr 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.UniRule annotation

    Catalytic activityi

    4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3.UniRule annotation

    Cofactori

    Binds 1 dipyrromethane group covalently.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. hydroxymethylbilane synthase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. peptidyl-pyrromethane cofactor linkage Source: InterPro
    2. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Porphyrin biosynthesis

    Enzyme and pathway databases

    BioCyciBPSE320373:GJ9C-1070-MONOMER.
    UniPathwayiUPA00251; UER00319.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Porphobilinogen deaminaseUniRule annotation (EC:2.5.1.61UniRule annotation)
    Short name:
    PBGUniRule annotation
    Alternative name(s):
    Hydroxymethylbilane synthaseUniRule annotation
    Short name:
    HMBSUniRule annotation
    Pre-uroporphyrinogen synthaseUniRule annotation
    Gene namesi
    Name:hemCUniRule annotation
    Ordered Locus Names:BURPS668_1071
    OrganismiBurkholderia pseudomallei (strain 668)
    Taxonomic identifieri320373 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
    ProteomesiUP000002153: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 329329Porphobilinogen deaminasePRO_1000047740Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei250 – 2501S-(dipyrrolylmethanemethyl)cysteineUniRule annotation

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi320373.BURPS668_1071.

    Structurei

    3D structure databases

    ProteinModelPortaliA3N700.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HMBS family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0181.
    HOGENOMiHOG000228587.
    KOiK01749.
    OMAiGIECRTD.
    OrthoDBiEOG6HB9Z6.

    Family and domain databases

    Gene3Di3.30.160.40. 1 hit.
    HAMAPiMF_00260. Porphobil_deam.
    InterProiIPR000860. 4pyrrol_synth_OHMeBilane_synth.
    IPR022419. Porphobilin_deaminase_cofac_BS.
    IPR022417. Porphobilin_deaminase_N.
    IPR022418. Porphobilinogen_deaminase_C.
    [Graphical view]
    PANTHERiPTHR11557. PTHR11557. 1 hit.
    PfamiPF01379. Porphobil_deam. 1 hit.
    PF03900. Porphobil_deamC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001438. 4pyrrol_synth_OHMeBilane_synth. 1 hit.
    PRINTSiPR00151. PORPHBDMNASE.
    SUPFAMiSSF54782. SSF54782. 1 hit.
    TIGRFAMsiTIGR00212. hemC. 1 hit.
    PROSITEiPS00533. PORPHOBILINOGEN_DEAM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A3N700-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSETLPAEL PATLTIASRE SRLAMWQAEH VRDALRKLYP ACDVKILGMT    50
    TRGDQILDRT LSKVGGKGLF VKELESALAD GRADLAVHSL KDVPMVLPEG 100
    FALAAVMSRE DPRDAFVSND YASLDALPAG AVVGTSSLRR EAMLRARHPR 150
    LDVRPLRGNL DTRLAKLDRG DYAAIILAAA GLKRLGLAAR IRALLDVDDS 200
    LPAAGQGALG IEIAARRADV AAWLAPLHDH ASALAVEAER AVSRALGGSC 250
    EVPLAAHAVW RGGELHLTGS VSTTDGARVL AAHAHARAAT AADALALGRR 300
    VSDALERQGA RAIVDALVAA SAQAQKGGA 329
    Length:329
    Mass (Da):34,437
    Last modified:April 3, 2007 - v1
    Checksum:i0867C598860852BD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000570 Genomic DNA. Translation: ABN82304.1.
    RefSeqiYP_001058121.1. NC_009074.1.

    Genome annotation databases

    EnsemblBacteriaiABN82304; ABN82304; BURPS668_1071.
    GeneIDi4883458.
    KEGGibpd:BURPS668_1071.
    PATRICi19248097. VBIBurPse82117_1021.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000570 Genomic DNA. Translation: ABN82304.1 .
    RefSeqi YP_001058121.1. NC_009074.1.

    3D structure databases

    ProteinModelPortali A3N700.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 320373.BURPS668_1071.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABN82304 ; ABN82304 ; BURPS668_1071 .
    GeneIDi 4883458.
    KEGGi bpd:BURPS668_1071.
    PATRICi 19248097. VBIBurPse82117_1021.

    Phylogenomic databases

    eggNOGi COG0181.
    HOGENOMi HOG000228587.
    KOi K01749.
    OMAi GIECRTD.
    OrthoDBi EOG6HB9Z6.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00319 .
    BioCyci BPSE320373:GJ9C-1070-MONOMER.

    Family and domain databases

    Gene3Di 3.30.160.40. 1 hit.
    HAMAPi MF_00260. Porphobil_deam.
    InterProi IPR000860. 4pyrrol_synth_OHMeBilane_synth.
    IPR022419. Porphobilin_deaminase_cofac_BS.
    IPR022417. Porphobilin_deaminase_N.
    IPR022418. Porphobilinogen_deaminase_C.
    [Graphical view ]
    PANTHERi PTHR11557. PTHR11557. 1 hit.
    Pfami PF01379. Porphobil_deam. 1 hit.
    PF03900. Porphobil_deamC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001438. 4pyrrol_synth_OHMeBilane_synth. 1 hit.
    PRINTSi PR00151. PORPHBDMNASE.
    SUPFAMi SSF54782. SSF54782. 1 hit.
    TIGRFAMsi TIGR00212. hemC. 1 hit.
    PROSITEi PS00533. PORPHOBILINOGEN_DEAM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. DeShazer D., Woods D.E., Nierman W.C.
      Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 668.

    Entry informationi

    Entry nameiHEM3_BURP6
    AccessioniPrimary (citable) accession number: A3N700
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The porphobilinogen subunits are added to the dipyrromethane group.UniRule annotation

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3