Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Porphobilinogen deaminase

Gene

hemC

Organism
Burkholderia pseudomallei (strain 668)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.UniRule annotation

Catalytic activityi

4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3.UniRule annotation

Cofactori

dipyrromethaneUniRule annotationNote: Binds 1 dipyrromethane group covalently.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. hydroxymethylbilane synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. peptidyl-pyrromethane cofactor linkage Source: InterPro
  2. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Porphyrin biosynthesis

Enzyme and pathway databases

BioCyciBPSE320373:GJ9C-1070-MONOMER.
UniPathwayiUPA00251; UER00319.

Names & Taxonomyi

Protein namesi
Recommended name:
Porphobilinogen deaminaseUniRule annotation (EC:2.5.1.61UniRule annotation)
Short name:
PBGUniRule annotation
Alternative name(s):
Hydroxymethylbilane synthaseUniRule annotation
Short name:
HMBSUniRule annotation
Pre-uroporphyrinogen synthaseUniRule annotation
Gene namesi
Name:hemCUniRule annotation
Ordered Locus Names:BURPS668_1071
OrganismiBurkholderia pseudomallei (strain 668)
Taxonomic identifieri320373 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
ProteomesiUP000002153: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 329329Porphobilinogen deaminasePRO_1000047740Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei250 – 2501S-(dipyrrolylmethanemethyl)cysteineUniRule annotation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi320373.BURPS668_1071.

Structurei

3D structure databases

ProteinModelPortaliA3N700.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HMBS family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0181.
HOGENOMiHOG000228587.
KOiK01749.
OMAiGIECRTD.
OrthoDBiEOG6HB9Z6.

Family and domain databases

Gene3Di3.30.160.40. 1 hit.
HAMAPiMF_00260. Porphobil_deam.
InterProiIPR000860. 4pyrrol_synth_OHMeBilane_synth.
IPR022419. Porphobilin_deaminase_cofac_BS.
IPR022417. Porphobilin_deaminase_N.
IPR022418. Porphobilinogen_deaminase_C.
[Graphical view]
PANTHERiPTHR11557. PTHR11557. 1 hit.
PfamiPF01379. Porphobil_deam. 1 hit.
PF03900. Porphobil_deamC. 1 hit.
[Graphical view]
PIRSFiPIRSF001438. 4pyrrol_synth_OHMeBilane_synth. 1 hit.
PRINTSiPR00151. PORPHBDMNASE.
SUPFAMiSSF54782. SSF54782. 1 hit.
TIGRFAMsiTIGR00212. hemC. 1 hit.
PROSITEiPS00533. PORPHOBILINOGEN_DEAM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3N700-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNSETLPAEL PATLTIASRE SRLAMWQAEH VRDALRKLYP ACDVKILGMT
60 70 80 90 100
TRGDQILDRT LSKVGGKGLF VKELESALAD GRADLAVHSL KDVPMVLPEG
110 120 130 140 150
FALAAVMSRE DPRDAFVSND YASLDALPAG AVVGTSSLRR EAMLRARHPR
160 170 180 190 200
LDVRPLRGNL DTRLAKLDRG DYAAIILAAA GLKRLGLAAR IRALLDVDDS
210 220 230 240 250
LPAAGQGALG IEIAARRADV AAWLAPLHDH ASALAVEAER AVSRALGGSC
260 270 280 290 300
EVPLAAHAVW RGGELHLTGS VSTTDGARVL AAHAHARAAT AADALALGRR
310 320
VSDALERQGA RAIVDALVAA SAQAQKGGA
Length:329
Mass (Da):34,437
Last modified:April 3, 2007 - v1
Checksum:i0867C598860852BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000570 Genomic DNA. Translation: ABN82304.1.
RefSeqiWP_011851244.1. NC_009074.1.
YP_001058121.1. NC_009074.1.

Genome annotation databases

EnsemblBacteriaiABN82304; ABN82304; BURPS668_1071.
GeneIDi4883458.
KEGGibpd:BURPS668_1071.
PATRICi19248097. VBIBurPse82117_1021.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000570 Genomic DNA. Translation: ABN82304.1.
RefSeqiWP_011851244.1. NC_009074.1.
YP_001058121.1. NC_009074.1.

3D structure databases

ProteinModelPortaliA3N700.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi320373.BURPS668_1071.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABN82304; ABN82304; BURPS668_1071.
GeneIDi4883458.
KEGGibpd:BURPS668_1071.
PATRICi19248097. VBIBurPse82117_1021.

Phylogenomic databases

eggNOGiCOG0181.
HOGENOMiHOG000228587.
KOiK01749.
OMAiGIECRTD.
OrthoDBiEOG6HB9Z6.

Enzyme and pathway databases

UniPathwayiUPA00251; UER00319.
BioCyciBPSE320373:GJ9C-1070-MONOMER.

Family and domain databases

Gene3Di3.30.160.40. 1 hit.
HAMAPiMF_00260. Porphobil_deam.
InterProiIPR000860. 4pyrrol_synth_OHMeBilane_synth.
IPR022419. Porphobilin_deaminase_cofac_BS.
IPR022417. Porphobilin_deaminase_N.
IPR022418. Porphobilinogen_deaminase_C.
[Graphical view]
PANTHERiPTHR11557. PTHR11557. 1 hit.
PfamiPF01379. Porphobil_deam. 1 hit.
PF03900. Porphobil_deamC. 1 hit.
[Graphical view]
PIRSFiPIRSF001438. 4pyrrol_synth_OHMeBilane_synth. 1 hit.
PRINTSiPR00151. PORPHBDMNASE.
SUPFAMiSSF54782. SSF54782. 1 hit.
TIGRFAMsiTIGR00212. hemC. 1 hit.
PROSITEiPS00533. PORPHOBILINOGEN_DEAM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. DeShazer D., Woods D.E., Nierman W.C.
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 668.

Entry informationi

Entry nameiHEM3_BURP6
AccessioniPrimary (citable) accession number: A3N700
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: January 7, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The porphobilinogen subunits are added to the dipyrromethane group.UniRule annotation

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.