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A3N700

- HEM3_BURP6

UniProt

A3N700 - HEM3_BURP6

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Protein
Porphobilinogen deaminase
Gene
hemC, BURPS668_1071
Organism
Burkholderia pseudomallei (strain 668)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps By similarity.UniRule annotation

Catalytic activityi

4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3.UniRule annotation

Cofactori

Binds 1 dipyrromethane group covalently By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. hydroxymethylbilane synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. peptidyl-pyrromethane cofactor linkage Source: InterPro
  2. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Porphyrin biosynthesis

Enzyme and pathway databases

BioCyciBPSE320373:GJ9C-1070-MONOMER.
UniPathwayiUPA00251; UER00319.

Names & Taxonomyi

Protein namesi
Recommended name:
Porphobilinogen deaminase (EC:2.5.1.61)
Short name:
PBG
Alternative name(s):
Hydroxymethylbilane synthase
Short name:
HMBS
Pre-uroporphyrinogen synthase
Gene namesi
Name:hemC
Ordered Locus Names:BURPS668_1071
OrganismiBurkholderia pseudomallei (strain 668)
Taxonomic identifieri320373 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
ProteomesiUP000002153: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 329329Porphobilinogen deaminaseUniRule annotation
PRO_1000047740Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei250 – 2501S-(dipyrrolylmethanemethyl)cysteine By similarity

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi320373.BURPS668_1071.

Structurei

3D structure databases

ProteinModelPortaliA3N700.

Family & Domainsi

Sequence similaritiesi

Belongs to the HMBS family.

Phylogenomic databases

eggNOGiCOG0181.
HOGENOMiHOG000228587.
KOiK01749.
OMAiGIECRTD.
OrthoDBiEOG6HB9Z6.

Family and domain databases

Gene3Di3.30.160.40. 1 hit.
HAMAPiMF_00260. Porphobil_deam.
InterProiIPR000860. 4pyrrol_synth_OHMeBilane_synth.
IPR022419. Porphobilin_deaminase_cofac_BS.
IPR022417. Porphobilin_deaminase_N.
IPR022418. Porphobilinogen_deaminase_C.
[Graphical view]
PANTHERiPTHR11557. PTHR11557. 1 hit.
PfamiPF01379. Porphobil_deam. 1 hit.
PF03900. Porphobil_deamC. 1 hit.
[Graphical view]
PIRSFiPIRSF001438. 4pyrrol_synth_OHMeBilane_synth. 1 hit.
PRINTSiPR00151. PORPHBDMNASE.
SUPFAMiSSF54782. SSF54782. 1 hit.
TIGRFAMsiTIGR00212. hemC. 1 hit.
PROSITEiPS00533. PORPHOBILINOGEN_DEAM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3N700-1 [UniParc]FASTAAdd to Basket

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MNSETLPAEL PATLTIASRE SRLAMWQAEH VRDALRKLYP ACDVKILGMT    50
TRGDQILDRT LSKVGGKGLF VKELESALAD GRADLAVHSL KDVPMVLPEG 100
FALAAVMSRE DPRDAFVSND YASLDALPAG AVVGTSSLRR EAMLRARHPR 150
LDVRPLRGNL DTRLAKLDRG DYAAIILAAA GLKRLGLAAR IRALLDVDDS 200
LPAAGQGALG IEIAARRADV AAWLAPLHDH ASALAVEAER AVSRALGGSC 250
EVPLAAHAVW RGGELHLTGS VSTTDGARVL AAHAHARAAT AADALALGRR 300
VSDALERQGA RAIVDALVAA SAQAQKGGA 329
Length:329
Mass (Da):34,437
Last modified:April 3, 2007 - v1
Checksum:i0867C598860852BD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000570 Genomic DNA. Translation: ABN82304.1.
RefSeqiYP_001058121.1. NC_009074.1.

Genome annotation databases

EnsemblBacteriaiABN82304; ABN82304; BURPS668_1071.
GeneIDi4883458.
KEGGibpd:BURPS668_1071.
PATRICi19248097. VBIBurPse82117_1021.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000570 Genomic DNA. Translation: ABN82304.1 .
RefSeqi YP_001058121.1. NC_009074.1.

3D structure databases

ProteinModelPortali A3N700.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 320373.BURPS668_1071.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABN82304 ; ABN82304 ; BURPS668_1071 .
GeneIDi 4883458.
KEGGi bpd:BURPS668_1071.
PATRICi 19248097. VBIBurPse82117_1021.

Phylogenomic databases

eggNOGi COG0181.
HOGENOMi HOG000228587.
KOi K01749.
OMAi GIECRTD.
OrthoDBi EOG6HB9Z6.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00319 .
BioCyci BPSE320373:GJ9C-1070-MONOMER.

Family and domain databases

Gene3Di 3.30.160.40. 1 hit.
HAMAPi MF_00260. Porphobil_deam.
InterProi IPR000860. 4pyrrol_synth_OHMeBilane_synth.
IPR022419. Porphobilin_deaminase_cofac_BS.
IPR022417. Porphobilin_deaminase_N.
IPR022418. Porphobilinogen_deaminase_C.
[Graphical view ]
PANTHERi PTHR11557. PTHR11557. 1 hit.
Pfami PF01379. Porphobil_deam. 1 hit.
PF03900. Porphobil_deamC. 1 hit.
[Graphical view ]
PIRSFi PIRSF001438. 4pyrrol_synth_OHMeBilane_synth. 1 hit.
PRINTSi PR00151. PORPHBDMNASE.
SUPFAMi SSF54782. SSF54782. 1 hit.
TIGRFAMsi TIGR00212. hemC. 1 hit.
PROSITEi PS00533. PORPHOBILINOGEN_DEAM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. DeShazer D., Woods D.E., Nierman W.C.
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 668.

Entry informationi

Entry nameiHEM3_BURP6
AccessioniPrimary (citable) accession number: A3N700
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: May 14, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The porphobilinogen subunits are added to the dipyrromethane group By similarity.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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