A3N3P6 (A3N3P6_ACTP2) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
DNA mismatch repair protein mutL HAMAP MF_00149

Gene names

Name:	mutL HAMAP MF_00149
Ordered Locus Names:	APL_1958

Organism

Actinobacillus pleuropneumoniae serotype 5b (strain L20) [Complete proteome] [HAMAP] EMBL ABN75032.1

Taxonomic identifier

416269 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length	622 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex By similarity. HAMAP MF_00149 SAAS SAAS020667
Sequence similarities	Belongs to the DNA mismatch repair mutL/hexB family. HAMAP MF_00149

Ontologies

Keywords
Biological process	DNA damage DNA repair HAMAP MF_00149 SAAS SAAS020667
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	mismatch repair Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro mismatched DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A3N3P6 [UniParc]. Last modified April 3, 2007. Version 1. Checksum: 2DFE5BDA12D58125	FASTA	622	69,428
	10 20 30 40 50 60 MNKPLIHILP PQLANQIAAG EVVERPASVV KELVENSLDA GANQIQIDIE KGGAQLIRIR 70 80 90 100 110 120 DNGCGIGKQD LALALARHAT SKISSLEDLE MILSLGFRGE ALASISSVSR LTLTSRPAGQ 130 140 150 160 170 180 AEAWQAYAQG REMEVEIQPA SHPVGTTIEV ANLFFNTPAR RKFLRTDKTE FTHIDEVVRR 190 200 210 220 230 240 IALAKPNIGF TLTHNGKTVR QYRKVQDNSV EQQQRRVAAI CGDDFIQNAI HIDWQHGDLH 250 260 270 280 290 300 LHGWIGLPNI SRPQNDLCYS YVNGRMMRDK TINHAIRQAY EATDMPEGNY PAFVVFLDID 310 320 330 340 350 360 PSQVDVNVHP AKHEVRFHQG RLVHDFILQG VQTALQGQSE IGLTDQVNEP LPSYQRDTNR 370 380 390 400 410 420 MAAGGNSFLA PQQAVEFSEN FVKPTASRMP SYSPRTTSVS KSAQKWYGEL ISQPQPQSDN 430 440 450 460 470 480 RQDFVEPKTN AAPVIFAQER VEAEHKPIQS VPMKSDHWQP LAIVQNQALL LKADQQFYLI 490 500 510 520 530 540 SLEKLARLRF QTQLAKGESQ ALLIPLNLSL DEVQAQHWQI LKAPLAELGF VISEKAWQGQ 550 560 570 580 590 600 IRLSLSQVPR LLREQNLQQI LLGLLTAQAV DLVEFFAKFA PIPTSYSLAE AVNWLAETEQ 610 620 SAKSELEKLK VAVDFSAFLA IC

References

[1]	"The complete genome sequence of Actinobacillus pleuropneumoniae L20 (serotype 5b)." Foote S.J., Bosse J.T., Bouevitch A.B., Langford P.R., Young N.M., Nash J.H.E. J. Bacteriol. 190:1495-1496(2008) [PubMed: 18065534] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000569 Genomic DNA. Translation: ABN75032.1.
RefSeq	YP_001054637.1. NC_009053.1.
3D structure databases
ProteinModelPortal	A3N3P6.
SMR	A3N3P6. Positions 6-336.
ModBase	Search...
Protein-protein interaction databases
STRING	A3N3P6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4848584.
GenomeReviews	Gene locus APL_1958 in contig CP000569_GR.
KEGG	apl:APL_1958.
PATRIC	20749012. VBIActPle94089_2039.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0323.
HOGENOM	HBG520262.
OMA	EVANLFF.
PhylomeDB	A3N3P6.
ProtClustDB	PRK00095.
Family and domain databases
HAMAP	MF_00149. DNA_mis_repair. [Tree]
InterPro	IPR003594. ATPase-like_ATP-bd. IPR002099. DNA_mismatch_repair. IPR013507. DNA_mismatch_repair_C. IPR014762. DNA_mismatch_repair_CS. IPR020667. DNA_mismatch_repair_MutL. IPR014763. DNA_mismatch_repair_N. IPR014790. MutL_C. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. [Graphical view]
Gene3D	G3DSA:3.30.565.10. ATP_bd_ATPase. 1 hit. G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
KO	K03572.
PANTHER	PTHR10073. DNA_mis_repair. 1 hit.
Pfam	PF01119. DNA_mis_repair. 1 hit. PF02518. HATPase_c. 1 hit. PF08676. MutL_C. 1 hit. [Graphical view]
SMART	SM00387. HATPase_c. 1 hit. SM00853. MutL_C. 1 hit. [Graphical view]
SUPFAM	SSF55874. ATP_bd_ATPase. 1 hit. SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMs	TIGR00585. Mutl. 1 hit.
PROSITE	PS00058. DNA_MISMATCH_REPAIR_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A3N3P6_ACTP2

Accession

Primary (citable) accession number: A3N3P6

Entry history

Integrated into UniProtKB/TrEMBL:	April 3, 2007
Last sequence update:	April 3, 2007
Last modified:	December 14, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)