A3N3P3 (PROA_ACTP2) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 42.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Gamma-glutamyl phosphate reductase Short name=GPR EC=1.2.1.41 Alternative name(s): Glutamate-5-semialdehyde dehydrogenase Glutamyl-gamma-semialdehyde dehydrogenase Short name=GSA dehydrogenase | ||||
| Gene names |
| ||||
| Organism | Actinobacillus pleuropneumoniae serotype 5b (strain L20) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 416269 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus |
Protein attributes
| Sequence length | 412 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. HAMAP MF_00412 |
| Catalytic activity | L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH. HAMAP MF_00412 |
| Pathway | Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2. HAMAP MF_00412 |
| Subcellular location | Cytoplasm By similarity HAMAP MF_00412. |
| Sequence similarities | Belongs to the gamma-glutamyl phosphate reductase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Proline biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | proline biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | NADP binding Inferred from electronic annotation. Source: InterPro glutamate-5-semialdehyde dehydrogenase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 412 | 412 | Gamma-glutamyl phosphate reductase HAMAP MF_00412 | PRO_1000049931 | |||
Sequences
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References
| [1] | "The complete genome sequence of Actinobacillus pleuropneumoniae L20 (serotype 5b)." Foote S.J., Bosse J.T., Bouevitch A.B., Langford P.R., Young N.M., Nash J.H.E. J. Bacteriol. 190:1495-1496(2008) [PubMed: 18065534] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: L20. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000569 Genomic DNA. Translation: ABN75029.1. |
| RefSeq | YP_001054634.1. NC_009053.1. |
3D structure databases | |
| ProteinModelPortal | A3N3P3. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | A3N3P3. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 4848580. |
| GenomeReviews | Gene locus APL_1951 in contig CP000569_GR. |
| KEGG | apl:APL_1951. |
| PATRIC | 20748996. VBIActPle94089_2031. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG0014. |
| HOGENOM | HBG318080. |
| OMA | QYPAACN. |
| PhylomeDB | A3N3P3. |
| ProtClustDB | PRK00197. |
Enzyme and pathway databases | |
| BioCyc | APLE416269:APL_1951-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00412. ProA. [Tree] |
| InterPro | IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. IPR000965. G-glutamylP_reductase. IPR012134. Glu-5-SA_DH. [Graphical view] |
| Gene3D | G3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit. G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 2 hits. |
| KO | K00147. |
| PANTHER | PTHR11063:SF1. GSA_DH. 1 hit. |
| Pfam | PF00171. Aldedh. 1 hit. [Graphical view] |
| PIRSF | PIRSF000151. GPR. 1 hit. |
| SUPFAM | SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit. |
| TIGRFAMs | TIGR00407. ProA. 1 hit. |
| PROSITE | PS01223. PROA. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | PROA_ACTP2 | ||||||||
| Accession | Primary (citable) accession number: A3N3P3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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