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A3N3M9 (HEMH_ACTP2) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:APL_1937
OrganismActinobacillus pleuropneumoniae serotype 5b (strain L20) [Complete proteome] [HAMAP]
Taxonomic identifier416269 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length319 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 319319Ferrochelatase HAMAP MF_00323
PRO_1000019270

Sites

Metal binding1931Iron By similarity
Metal binding2741Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
A3N3M9 [UniParc].

Last modified April 3, 2007. Version 1.
Checksum: 8C6602FC6356C3BE

FASTA31936,279
        10         20         30         40         50         60 
MNTNKIGVLL ANLGTPDEPT TPAVKRYLKQ FLSDPRVIDL PKFKWQFILN YMILPKRSPK 

        70         80         90        100        110        120 
VAKLYREIWT EQGSPLLAIS RQQQQALQDY FNRQNQNVLV ELGMSYGNPS IESATDRLIK 

       130        140        150        160        170        180 
AGVSKIIVLP LYPQYSSTTT ASVLDAFARG LTQQRNIVPF EFIHSYHNDP LYIQALANTI 

       190        200        210        220        230        240 
RLADDEKLLF SFHGIPKRYQ TEGDFYPEHC QKTAQLVADK LSLSNEQWLV TYQSRFGDEE 

       250        260        270        280        290        300 
WLQPYTDETL EKLPSQGVKK IAVICAGFSA DCLETLEEIA EENKENFLNA GGQSYRYIPA 

       310 
LNANTDHINA LAKLIEAKI

« Hide

References

[1]"The complete genome sequence of Actinobacillus pleuropneumoniae L20 (serotype 5b)."
Foote S.J., Bosse J.T., Bouevitch A.B., Langford P.R., Young N.M., Nash J.H.E.
J. Bacteriol. 190:1495-1496(2008) [PubMed: 18065534] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: L20.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000569 Genomic DNA. Translation: ABN75015.1.
RefSeqYP_001054620.1. NC_009053.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA3N3M9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4850278.
GenomeReviewsGene locus APL_1937 in contig CP000569_GR.
KEGGapl:APL_1937.
PATRIC20748968. VBIActPle94089_2017.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0276.
HOGENOMHBG697135.
OMATIEEIGM.
PhylomeDBA3N3M9.
ProtClustDBCLSK965681.

Enzyme and pathway databases

BioCycAPLE416269:APL_1937-MONOMER.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_ACTP2
AccessionPrimary (citable) accession number: A3N3M9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: December 14, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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