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A3N3F7 (DAPD_ACTP2) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase

EC=2.3.1.117
Alternative name(s):
Tetrahydrodipicolinate N-succinyltransferase
Short name=THDP succinyltransferase
Short name=THP succinyltransferase
Short name=Tetrahydropicolinate succinylase
Gene names
Name:dapD
Ordered Locus Names:APL_1861
OrganismActinobacillus pleuropneumoniae serotype 5b (strain L20) [Complete proteome] [HAMAP]
Taxonomic identifier416269 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeActinobacillus

Protein attributes

Sequence length274 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O = CoA + N-succinyl-L-2-amino-6-oxoheptanedioate. HAMAP-Rule MF_00811

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 1/3. HAMAP-Rule MF_00811

Subunit structure

Homotrimer By similarity. HAMAP-Rule MF_00811

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00811.

Sequence similarities

Belongs to the transferase hexapeptide repeat family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2742742,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase HAMAP-Rule MF_00811
PRO_1000047113

Sites

Binding site1031Substrate By similarity
Binding site1401Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
A3N3F7 [UniParc].

Last modified April 3, 2007. Version 1.
Checksum: 91B1CB6831599E4D

FASTA27429,692
        10         20         30         40         50         60 
MSLQAIIEAA FERRAEITPK TVDAETRAAI EEVIEGLDSG KYRVAEKIDG EWVTHQWLKK 

        70         80         90        100        110        120 
AVLLSFRIND NQIIDGAETK YYDKVALKFA DYTEERFAQE GFRVVPSATV RKGAYISKNC 

       130        140        150        160        170        180 
VLMPSYVNIG AYVGEGTMVD TWATVGSCAQ IGKNVHLSGG VGIGGVLEPL QANPTIIGDN 

       190        200        210        220        230        240 
CFIGARSEVV EGVIVEDGCV ISMGVFIGQS TRIYDRETGE IHYGRVPAGS VVVSGSLPSK 

       250        260        270 
CGKYSLYCAV IVKKVDAKTL GKVGINELLR TIEE 

« Hide

References

[1]"The complete genome sequence of Actinobacillus pleuropneumoniae L20 (serotype 5b)."
Foote S.J., Bosse J.T., Bouevitch A.B., Langford P.R., Young N.M., Nash J.H.E.
J. Bacteriol. 190:1495-1496(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: L20.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000569 Genomic DNA. Translation: ABN74943.1.
RefSeqYP_001054548.1. NC_009053.1.

3D structure databases

ProteinModelPortalA3N3F7.
SMRA3N3F7. Positions 3-273.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING416269.APL_1861.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABN74943; ABN74943; APL_1861.
GeneID4848540.
KEGGapl:APL_1861.
PATRIC20748807. VBIActPle94089_1937.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2171.
HOGENOMHOG000003295.
KOK00674.
OMAYIARNTV.
OrthoDBEOG68H8BV.

Enzyme and pathway databases

BioCycAPLE416269:GHV7-1928-MONOMER.
UniPathwayUPA00034; UER00019.

Family and domain databases

Gene3D1.10.166.10. 1 hit.
HAMAPMF_00811. DapD.
InterProIPR005664. DapD_Trfase_Hexpep_rpt_fam.
IPR001451. Hexapep_transf.
IPR018357. Hexapep_transf_CS.
IPR023180. THP_succinylTrfase_dom1.
IPR011004. Trimer_LpxA-like.
[Graphical view]
PANTHERPTHR19136:SF52. PTHR19136:SF52. 1 hit.
PfamPF00132. Hexapep. 1 hit.
PF14805. THDPS_N_2. 1 hit.
[Graphical view]
SUPFAMSSF51161. SSF51161. 1 hit.
TIGRFAMsTIGR00965. dapD. 1 hit.
PROSITEPS00101. HEXAPEP_TRANSFERASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDAPD_ACTP2
AccessionPrimary (citable) accession number: A3N3F7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways