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A3N3E5

- LLDD_ACTP2

UniProt

A3N3E5 - LLDD_ACTP2

Protein

L-lactate dehydrogenase

Gene

lldD

Organism
Actinobacillus pleuropneumoniae serotype 5b (strain L20)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain.UniRule annotation

    Catalytic activityi

    (S)-lactate + an oxidized electron acceptor = pyruvate + a reduced electron acceptor.UniRule annotation

    Cofactori

    FMN.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei24 – 241SubstrateUniRule annotation
    Binding sitei106 – 1061FMNUniRule annotation
    Binding sitei127 – 1271FMNUniRule annotation
    Binding sitei129 – 1291SubstrateUniRule annotation
    Binding sitei155 – 1551FMNUniRule annotation
    Binding sitei164 – 1641SubstrateUniRule annotation
    Binding sitei251 – 2511FMNUniRule annotation
    Active sitei275 – 2751Proton acceptorUniRule annotation
    Binding sitei278 – 2781SubstrateUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi306 – 33025FMNUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. FMN binding Source: InterPro
    2. L-lactate dehydrogenase (cytochrome) activity Source: InterPro

    GO - Biological processi

    1. lactate oxidation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Flavoprotein, FMN

    Enzyme and pathway databases

    BioCyciAPLE416269:GHV7-1916-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    L-lactate dehydrogenaseUniRule annotation (EC:1.1.-.-UniRule annotation)
    Gene namesi
    Name:lldDUniRule annotation
    Ordered Locus Names:APL_1849
    OrganismiActinobacillus pleuropneumoniae serotype 5b (strain L20)
    Taxonomic identifieri416269 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeActinobacillus
    ProteomesiUP000001432: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

    GO - Cellular componenti

    1. plasma membrane Source: UniProtKB-HAMAP

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 381381L-lactate dehydrogenasePRO_1000068976Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi416269.APL_1849.

    Structurei

    3D structure databases

    ProteinModelPortaliA3N3E5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 380380FMN hydroxy acid dehydrogenaseUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.UniRule annotation
    Contains 1 FMN hydroxy acid dehydrogenase domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1304.
    HOGENOMiHOG000217464.
    KOiK00101.
    OMAiDCTLLGR.
    OrthoDBiEOG6HMXBG.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01559. L_lact_dehydr.
    InterProiIPR013785. Aldolase_TIM.
    IPR012133. Alpha-hydoxy_acid_DH_FMN.
    IPR000262. FMN-dep_DH.
    IPR008259. FMN_hydac_DH_AS.
    IPR020920. L-lactate_DHase_bac.
    [Graphical view]
    PfamiPF01070. FMN_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000138. Al-hdrx_acd_dh. 1 hit.
    PROSITEiPS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
    PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A3N3E5-1 [UniParc]FASTAAdd to Basket

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    MIISSANDYR EAARRRVPPF MFHYADGGSF SERTLERNVT DLADLALRQR    50
    VLKDMSQLDT EIELFGEKLA MPAVLAPVGA CGMYARRGEV QAAQAAENKG 100
    IPFTLSTVSI CPIEEVTAAI KRPMWFQLYV LKDRGFMKHV LERAKAAGCS 150
    TLVFTVDMPT PGARYRDRHS GMSGDYKEIR RALQAVTHPF WAWDVGIKGK 200
    PHTLGNVSAY TGKAVGLDDY VVWLGENFDP SISWKDLEWI RDFWDGPMVI 250
    KGILDPEDAK DAVRFGADGI VVSNHGGRQL DGALSSARAL PSIADAVKGD 300
    IKILADSGIR NGLDIVRMLA LGADATMLGR AFVYALGAAG KAGVENMLDI 350
    FKKEMHVAMT LTSNQKISDI TRDALVDLSK L 381
    Length:381
    Mass (Da):41,752
    Last modified:April 3, 2007 - v1
    Checksum:i7F0C4EF49810528F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000569 Genomic DNA. Translation: ABN74931.1.
    RefSeqiYP_001054536.1. NC_009053.1.

    Genome annotation databases

    EnsemblBacteriaiABN74931; ABN74931; APL_1849.
    GeneIDi4849717.
    KEGGiapl:APL_1849.
    PATRICi20748783. VBIActPle94089_1925.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000569 Genomic DNA. Translation: ABN74931.1 .
    RefSeqi YP_001054536.1. NC_009053.1.

    3D structure databases

    ProteinModelPortali A3N3E5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 416269.APL_1849.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABN74931 ; ABN74931 ; APL_1849 .
    GeneIDi 4849717.
    KEGGi apl:APL_1849.
    PATRICi 20748783. VBIActPle94089_1925.

    Phylogenomic databases

    eggNOGi COG1304.
    HOGENOMi HOG000217464.
    KOi K00101.
    OMAi DCTLLGR.
    OrthoDBi EOG6HMXBG.

    Enzyme and pathway databases

    BioCyci APLE416269:GHV7-1916-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01559. L_lact_dehydr.
    InterProi IPR013785. Aldolase_TIM.
    IPR012133. Alpha-hydoxy_acid_DH_FMN.
    IPR000262. FMN-dep_DH.
    IPR008259. FMN_hydac_DH_AS.
    IPR020920. L-lactate_DHase_bac.
    [Graphical view ]
    Pfami PF01070. FMN_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000138. Al-hdrx_acd_dh. 1 hit.
    PROSITEi PS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
    PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Actinobacillus pleuropneumoniae L20 (serotype 5b)."
      Foote S.J., Bosse J.T., Bouevitch A.B., Langford P.R., Young N.M., Nash J.H.E.
      J. Bacteriol. 190:1495-1496(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: L20.

    Entry informationi

    Entry nameiLLDD_ACTP2
    AccessioniPrimary (citable) accession number: A3N3E5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3