Reviewed, UniProtKB/Swiss-Prot A3N2S7 (MTLD_ACTP2)

Names and origin

Protein names

Recommended name:
    Mannitol-1-phosphate 5-dehydrogenase
    EC=1.1.1.17

Gene names

Name:	mtlD
Ordered Locus Names:	APL_1629

Organism

Actinobacillus pleuropneumoniae serotype 5b (strain L20) [Complete proteome] [HAMAP]

Taxonomic identifier

416269 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length	379 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. HAMAP MF_00196
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 379	379	Mannitol-1-phosphate 5-dehydrogenase HAMAP MF_00196		PRO_1000011790
Regions
	Nucleotide binding	3 – 14	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	A3N2S7-1 [UniParc]. Last modified April 3, 2007. Version 1. Checksum: A0D7AE4413FD71B5	FASTA	379	41,648
	10 20 30 40 50 60 MNALHFGAGN IGRGFIGKLL ADSGVFVTFA DINQTQIDQI NQNKQYGVKI VGDASRVEVV 70 80 90 100 110 120 KNIAAINSKD EEAVIEQVKS VELITTAVGP NVLGFIAPLF AKALAARLEA GNTQPLNIIA 130 140 150 160 170 180 CENMVRGTSF FKAKIFENLT DSQQAEIEKF VGFVDSAVDR IVPPAELNEA DPLEVTVEEF 190 200 210 220 230 240 SEWIVDKTQF KGQIPDIKGM ELTDNLMAFV ERKLFTLNTG HLISAYLGKQ AGVKWIKEAI 250 260 270 280 290 300 AIDSVKAAVK ATMEESGAVL IKRYNFDPQA HAAYIEKILK RFANPYLNDD VNRVGREPIR 310 320 330 340 350 360 KLSPNDRLIK PLLGTLEYGL PHKNLVNGVV MALQYRNEED PQAVELAQFI ADNGVAAAVE 370 KYTGLTNQEV IDQVVALYN

References

[1]	"The complete genome sequence of Actinobacillus pleuropneumoniae L20 (serotype 5b)." Foote S.J., Bosse J.T., Bouevitch A.B., Langford P.R., Young N.M., Nash J.H.E. J. Bacteriol. 190:1495-1496(2008) [PubMed: 18065534] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000569 Genomic DNA. Translation: ABN74713.1.
RefSeq	YP_001054318.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A3N2S7.
Genome annotation databases
GeneID	4849415.
GenomeReviews	Gene locus APL_1629 in contig CP000569_GR.
KEGG	apl:APL_1629.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	VDRIVPN.
Family and domain databases
HAMAP	MF_00196. [Tree]
InterPro	IPR013328. DH_multihelical. IPR013118. Mannitol_DH_C. IPR000669. Mannitol_DH_core. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
PROSITE	PS00974. MANNITOL_DHGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_ACTP2

Accession

Primary (citable) accession number: A3N2S7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	April 3, 2007
Last modified:	November 3, 2009
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)