A3N2A2 (GLMM_ACTP2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoglucosamine mutase
EC=5.4.2.10

Gene names

Name:	glmM
Ordered Locus Names:	APL_1454

Organism

Actinobacillus pleuropneumoniae serotype 5b (strain L20) [Complete proteome] [HAMAP]

Taxonomic identifier

416269 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length	444 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate By similarity. HAMAP MF_01554_B
Catalytic activity	Alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate. HAMAP MF_01554_B
Cofactor	Binds 1 magnesium ion per subunit By similarity. HAMAP MF_01554_B
Post-translational modification	Activated by phosphorylation By similarity. HAMAP MF_01554_B
Sequence similarities	Belongs to the phosphohexose mutase family.

Ontologies

Keywords
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: InterPro phosphoglucosamine mutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 444	444	Phosphoglucosamine mutase HAMAP MF_01554_B		PRO_0000301271
Sites
	Active site	102	1	Phosphoserine intermediate By similarity
	Metal binding	102	1	Magnesium; via phosphate group By similarity
	Metal binding	241	1	Magnesium By similarity
	Metal binding	243	1	Magnesium By similarity
	Metal binding	245	1	Magnesium By similarity
Amino acid modifications
	Modified residue	102	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A3N2A2 [UniParc]. Last modified April 3, 2007. Version 1. Checksum: AA09923726E63D68	FASTA	444	47,313
	10 20 30 40 50 60 MAERKYFGTD GVRGKVGQFP ITPDFALKLG WAAGKILATQ GTKQVLIGKD TRISGYMLES 70 80 90 100 110 120 ALEAGLAAAG LSAAFVGPMP TPAIAYLTRT FRAEAGIVIS ASHNPYYDNG IKFFSSVGEK 130 140 150 160 170 180 LPDEVEEAIE ALLDQPMDCV ESAQLGKAMR INDAAGRYIE FCKGTFPANA SLKGYKIVVD 190 200 210 220 230 240 CANGATYHIA PNVMRELGAE VIEIGTKPDG LNINEKCGAT DIKALQKVVV ESGADVGLAY 250 260 270 280 290 300 DGDGDRIMMV DHLGNKVDGD QILFIIAREA LRSGKLHGGV VGTLMSNMGL EVALKHLAIP 310 320 330 340 350 360 FTRANVGDRY VLEQLKEKGW KLGGENSGHI IVLDKNTTGD GIIASLEVLA AMEAHKMSLN 370 380 390 400 410 420 DLARAVPLFP QVLINVRFEG GKNPLESDAV KAVAADVEKR LAGKGRILLR KSGTEPLIRV 430 440 MVECEDGALA QSCAEEIVEA VKSN

References

[1]	"The complete genome sequence of Actinobacillus pleuropneumoniae L20 (serotype 5b)." Foote S.J., Bosse J.T., Bouevitch A.B., Langford P.R., Young N.M., Nash J.H.E. J. Bacteriol. 190:1495-1496(2008) [PubMed: 18065534] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: L20.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000569 Genomic DNA. Translation: ABN74538.1.
RefSeq	YP_001054143.1. NC_009053.1.
3D structure databases
ProteinModelPortal	A3N2A2.
ModBase	Search...
Protein-protein interaction databases
STRING	A3N2A2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4849540.
GenomeReviews	Gene locus APL_1454 in contig CP000569_GR.
KEGG	apl:APL_1454.
PATRIC	20747895. VBIActPle94089_1513.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1109.
HOGENOM	HBG644964.
OMA	GVGSTHL.
PhylomeDB	A3N2A2.
ProtClustDB	PRK10887.
Enzyme and pathway databases
BioCyc	APLE416269:APL_1454-MONOMER.
Family and domain databases
HAMAP	MF_01554_B. GlmM_B. [Tree]
InterPro	IPR005844. A-D-PHexomutase_a/b/a-I. IPR016055. A-D-PHexomutase_a/b/a-I/II/III. IPR005845. A-D-PHexomutase_a/b/a-II. IPR005846. A-D-PHexomutase_a/b/a-III. IPR005843. A-D-PHexomutase_C. IPR016066. A-D-PHexomutase_CS. IPR005841. Alpha-D-phosphohexomutase_SF. IPR006352. GlmM. [Graphical view]
Gene3D	G3DSA:3.40.120.10. A-D-PHexomutase_a/b/a-I/II/III. 3 hits.
KO	K03431.
Pfam	PF02878. PGM_PMM_I. 1 hit. PF02879. PGM_PMM_II. 1 hit. PF02880. PGM_PMM_III. 1 hit. PF00408. PGM_PMM_IV. 1 hit. [Graphical view]
PRINTS	PR00509. PGMPMM.
SUPFAM	SSF53738. A-D-PHexomutase_a/b/a-I/II/III. 3 hits.
TIGRFAMs	TIGR01455. GlmM. 1 hit.
PROSITE	PS00710. PGM_PMM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLMM_ACTP2

Accession

Primary (citable) accession number: A3N2A2

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	April 3, 2007
Last modified:	December 14, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program