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Reviewed, UniProtKB/Swiss-Prot A3N298 (F16PA_ACTP2)

Last modified November 3, 2009. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Fructose-1,6-bisphosphatase class 1
      Short name=FBPase class 1
    EC=3.1.3.11
Alternative name(s):
    D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Gene names
Name: fbp
Ordered Locus Names: APL_1450
OrganismActinobacillus pleuropneumoniae serotype 5b (strain L20) [Complete proteome] [HAMAP]
Taxonomic identifier416269 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

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Protein attributes

Sequence length334 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. HAMAP MF_01855

Cofactor

Binds 2 magnesium ions per subunit By similarity.

Pathway

Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_01855

Subunit structure

Homotetramer By similarity.

Subcellular location

Cytoplasm Potential.

Sequence similarities

Belongs to the FBPase class 1 family.

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Ontologies

Keywords
   Biological processCarbohydrate metabolism
   Cellular componentCytoplasm
   LigandMagnesium
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processcarbohydrate biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionfructose 1,6-bisphosphate 1-phosphatase activity

Inferred from electronic annotation. Source: HAMAP

magnesium ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 334334Fructose-1,6-bisphosphatase class 1 HAMAP MF_01855
PRO_0000364453

Regions

Region116 – 1194Substrate binding By similarity

Sites

Metal binding901Magnesium 1 By similarity
Metal binding1131Magnesium 1 By similarity
Metal binding1131Magnesium 2 By similarity
Metal binding1151Magnesium 1; via carbonyl oxygen By similarity
Metal binding1161Magnesium 2 By similarity
Metal binding2781Magnesium 2 By similarity
Binding site2091Substrate By similarity
Binding site2421Substrate By similarity
Binding site2721Substrate By similarity

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Sequences

Sequence LengthMass (Da)Tools
A3N298-1 [UniParc].

Last modified April 3, 2007. Version 1.
Checksum: 7F4AE0AF9728F1FC

FASTA33436,937
        10         20         30         40         50         60 
MKTLGEFIIE KQAEYPEAKG ELSGILSSIR LAAKIIHREI NRAGLSQDIL GVAGSENIQG 

        70         80         90        100        110        120 
EAQMKLDVFA NETMKKALLA REEVAGFASE EDDNFVAFEN DRAKNAKYIL MTDPLDGSSN 

       130        140        150        160        170        180 
IDVNVSVGTI FSIYKRVSPI GSPVTMEDFL QEGRKQVASG YVTYGSSTML VYTTGNGVNG 

       190        200        210        220        230        240 
FTYDPSLGLF ILSHPDMKIP TEGKYYSINE GQYVTFPMGV KKFIKYCQES DEATKRPYSS 

       250        260        270        280        290        300 
RYIGSLVSDF HRNLLKGGIY IYPTSTVYPK GKLRLLYEGN PMAFLAEQAG GMATDGFNPI 

       310        320        330 
LDIKPSELHQ RVPFFVGSTS MVKQADKFMQ ECAE

« Hide

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References

[1]"The complete genome sequence of Actinobacillus pleuropneumoniae L20 (serotype 5b)."
Foote S.J., Bosse J.T., Bouevitch A.B., Langford P.R., Young N.M., Nash J.H.E.
J. Bacteriol. 190:1495-1496(2008) [PubMed: 18065534] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

CP000569 Genomic DNA. Translation: ABN74534.1.
RefSeqYP_001054139.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA3N298.

Genome annotation databases

GeneID4849228.
GenomeReviewsGene locus APL_1450 in contig CP000569_GR.
KEGGapl:APL_1450.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAQRHWEAP.

Family and domain databases

HAMAPMF_01855.
[Tree]
InterProIPR000146. Fructose_bisphosphatase.
IPR020548. Fructose_bisphosphatase_AS.
[Graphical view]
PANTHERPTHR11556. In_FB_phphtase. 1 hit.
PfamPF00316. FBPase. 1 hit.
[Graphical view]
PRINTSPR00115. F16BPHPHTASE.
ProDomPD001491. In_FB_phphtase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEPS00124. FBPASE. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameF16PA_ACTP2
AccessionPrimary (citable) accession number: A3N298
Entry history
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: April 3, 2007
Last modified: November 3, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents