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Protein

Probable malate:quinone oxidoreductase

Gene

mqo

Organism
Actinobacillus pleuropneumoniae serotype 5b (strain L20)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-malate + a quinone = oxaloacetate + reduced quinone.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable malate:quinone oxidoreductase (mqo)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandFAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01008.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable malate:quinone oxidoreductaseUniRule annotation (EC:1.1.5.4UniRule annotation)
Alternative name(s):
MQOUniRule annotation
Malate dehydrogenase [quinone]UniRule annotation
Gene namesi
Name:mqoUniRule annotation
Ordered Locus Names:APL_1414
OrganismiActinobacillus pleuropneumoniae serotype 5b (strain L20)
Taxonomic identifieri416269 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeActinobacillus
Proteomesi
  • UP000001432 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003254841 – 491Probable malate:quinone oxidoreductaseAdd BLAST491

Interactioni

Protein-protein interaction databases

STRINGi416269.APL_1414.

Structurei

3D structure databases

ProteinModelPortaliA3N262.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MQO family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DWT. Bacteria.
COG0579. LUCA.
HOGENOMiHOG000109379.
KOiK00116.
OMAiPQHDMAL.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
HAMAPiMF_00212. MQO. 1 hit.
InterProiView protein in InterPro
IPR036188. FAD/NAD-bd_sf.
IPR006231. MQO.
PfamiView protein in Pfam
PF06039. Mqo. 1 hit.
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR01320. mal_quin_oxido. 1 hit.

Sequencei

Sequence statusi: Complete.

A3N262-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQDSSSALES YSDVTLIGAG IMSGTLGAFL TELAPEKSLA IFEKLSAVGL
60 70 80 90 100
ESSNEWNNAG TGHSALCELN YTEQKANGEV SVERAVKICE DFQLSLQLWS
110 120 130 140 150
YLVETGRIQA PREFIHRIPH ISFVQGEQNA QFLQKRYQSL AQSHLFEGMQ
160 170 180 190 200
FSRDHQQLAQ WMPLMMQNRD SNETLAASYI QYGTDVNFGE LTRKLFDYLV
210 220 230 240 250
KQKAELNLNH TVKNIQRLAN GEWKLTVVDQ QGQKRVHRSK FVFIGGGGGA
260 270 280 290 300
LPLLQKSGIT DGKNVGGFPV SGLFMVCNNP EVIAKHNAKV YGKAKLGAPP
310 320 330 340 350
MSVPHLDTRF IEGKQSLLFG PFAGFTLKFL KQGSVLDLPT SVTPTNFCSV
360 370 380 390 400
TKAGIKNLPL AHYLMKQAML TKAQRMADLR EFVPDAKDED WDVVVAGQRV
410 420 430 440 450
QVIKGGEMRF GTEVIRAEDG SLAALLGASP GASTSVKAML DVLVSCFAAE
460 470 480 490
LPQWQAKLTQ MLPSYGKALR NEPQLYAQIK QRVDQVLALA N
Length:491
Mass (Da):54,074
Last modified:April 3, 2007 - v1
Checksum:iCB55915CE9BDA023
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000569 Genomic DNA. Translation: ABN74498.1.
RefSeqiWP_009875515.1. NC_009053.1.

Genome annotation databases

EnsemblBacteriaiABN74498; ABN74498; APL_1414.
GeneIDi4850549.
KEGGiapl:APL_1414.
PATRICifig|416269.6.peg.1473.

Similar proteinsi

Entry informationi

Entry nameiMQO_ACTP2
AccessioniPrimary (citable) accession number: A3N262
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: April 3, 2007
Last modified: October 25, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families