Reviewed, UniProtKB/Swiss-Prot A3N1Z1 (CDD_ACTP2)

Names and origin

Protein names

Recommended name:
    Cytidine deaminase
    EC=3.5.4.5
Alternative name(s):
    Cytidine aminohydrolase
      Short name=CDA

Gene names

Name:	cdd
Ordered Locus Names:	APL_1343

Organism

Actinobacillus pleuropneumoniae serotype 5b (strain L20) [Complete proteome] [HAMAP]

Taxonomic identifier

416269 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length	297 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis By similarity.
Catalytic activity	Cytidine + H2O = uridine + NH3. HAMAP MF_01558
Cofactor	Binds 1 zinc ion By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the cytidine and deoxycytidylate deaminase family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	cytidine deaminase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 297	297	Cytidine deaminase HAMAP MF_01558		PRO_0000318622
Regions
	Region	95 – 97	3	Substrate binding By similarity
Sites
	Active site	110	1	Proton donor By similarity
	Metal binding	108	1	Zinc; catalytic By similarity
	Metal binding	135	1	Zinc; catalytic By similarity
	Metal binding	138	1	Zinc; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	A3N1Z1-1 [UniParc]. Last modified April 3, 2007. Version 1. Checksum: BB3AE44FAC5CEAEF	FASTA	297	32,812
	10 20 30 40 50 60 MPTLFALKER IAQVVQEKND PIVTAVATTL AEQQYNACFS AEQVKLWKRQ FKCSSVELAL 70 80 90 100 110 120 ACLPIAACYA LVPISNFYVG AVAIGESGRF YFGANQEFNA QAIQQTVHAE QSAISHAWLA 130 140 150 160 170 180 GETAITDMVV NYTPCGHCRQ FMNELNSAKT LKIHLPHSQN NLLRQYLPDS FGPKDLNIEK 190 200 210 220 230 240 VLFDQQTHSL PLRGDLLTQA AIQTAAQSYA PYSKSLSGIA LQVGEQIICG RYAENAAFNP 250 260 270 280 290 SFLPLQSALN YRRLSGKSDE RISRIVMAES KGTTSHRQMS EALAESFLGL NLEYIEV

References

[1]	"The complete genome sequence of Actinobacillus pleuropneumoniae L20 (serotype 5b)." Foote S.J., Bosse J.T., Bouevitch A.B., Langford P.R., Young N.M., Nash J.H.E. J. Bacteriol. 190:1495-1496(2008) [PubMed: 18065534] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000569 Genomic DNA. Translation: ABN74427.1.
RefSeq	YP_001054032.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A3N1Z1.
Genome annotation databases
GeneID	4848536.
GenomeReviews	Gene locus APL_1343 in contig CP000569_GR.
KEGG	apl:APL_1343.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	FSPCGHC.
Family and domain databases
HAMAP	MF_01558. [Tree]
InterPro	IPR016192. APOBEC/CMP_deaminase_Zn-bd. IPR002125. CMP_dCMP_Zn_bd. IPR013171. Cyd/dCyd_deaminase_Zn_bd. [Graphical view]
Pfam	PF00383. dCMP_cyt_deam_1. 1 hit. PF08211. dCMP_cyt_deam_2. 1 hit. [Graphical view]
PROSITE	PS00903. CYT_DCMP_DEAMINASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDD_ACTP2

Accession

Primary (citable) accession number: A3N1Z1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	April 3, 2007
Last modified:	November 3, 2009
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)