Reviewed, UniProtKB/Swiss-Prot A3N1I1 (ARLY_ACTP2)

Names and origin

Protein names

Recommended name:
    Argininosuccinate lyase
      Short name=ASAL
    EC=4.3.2.1
Alternative name(s):
    Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	APL_1179

Organism

Actinobacillus pleuropneumoniae serotype 5b (strain L20) [Complete proteome] [HAMAP]

Taxonomic identifier

416269 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length	458 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm Probable HAMAP MF_00006.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 458	458	Argininosuccinate lyase HAMAP MF_00006		PRO_1000000447

Sequences

	Sequence		Length	Mass (Da)
	A3N1I1-1 [UniParc]. Last modified April 3, 2007. Version 1. Checksum: DF256A9ABA0A06A0	FASTA	458	51,036
	10 20 30 40 50 60 MALWGGRFKQ EADAKFKFFN DSLRFDYRLA LQDIDGSIGW AKAITSVGIL TEQEHQQLVV 70 80 90 100 110 120 ALKELRAEIE SNIAIILRDD AEDIHSWVES KLIEKVGDLG KKLHTGRSRN DQVAVDMKMW 130 140 150 160 170 180 CKVQAVVLQE RIRNLQHKLV ETAEANQNAV MPGYTHLQRA QPITFAHWCM AYYEMLERDF 190 200 210 220 230 240 SRLTDAYKRM HTCPLGSGAL AGTAYSIDRD ALAQDLGFAI GTRNSLDSVS DRDHVLELLS 250 260 270 280 290 300 TASISMVHLS RFAEDLIFFN SGESAFLELS DRVTSGSSLM PQKKNPDACE LIRGKSGRVF 310 320 330 340 350 360 GALSGLLTTL KGLPLAYNKD MQEDKEGIFD AMETWQACLE IGALVLEDIN VNVERTREAA 370 380 390 400 410 420 QQGYSNATEL ADYLVAKGIP FREAHHIVGE AVVYAISKRE PLEALSVAEF KQFHPVIDED 430 440 450 VYPILSLESC LEKRSAKGGV NPERVREAIE AAKVNLGA

References

[1]	"The complete genome sequence of Actinobacillus pleuropneumoniae L20 (serotype 5b)." Foote S.J., Bosse J.T., Bouevitch A.B., Langford P.R., Young N.M., Nash J.H.E. J. Bacteriol. 190:1495-1496(2008) [PubMed: 18065534] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000569 Genomic DNA. Translation: ABN74267.1.
RefSeq	YP_001053872.1.
3D structure databases
SMR	A3N1I1. Positions 3-457.
ModBase	Search...
Protein-protein interaction databases
STRING	A3N1I1.
Genome annotation databases
GeneID	4849954.
GenomeReviews	Gene locus APL_1179 in contig CP000569_GR.
KEGG	apl:APL_1179.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0165.
HOGENOM	HBG539632.
OMA	MAEDLIF.
PhylomeDB	A3N1I1.
Family and domain databases
HAMAP	MF_00006. Arg_succ_lyase. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR020557. Fumarate_lyase_CS. IPR008948. L-Aspartase-like. [Graphical view]
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
TIGRFAMs	TIGR00838. argH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_ACTP2

Accession

Primary (citable) accession number: A3N1I1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	April 3, 2007
Last modified:	February 9, 2010
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)