Reviewed, UniProtKB/Swiss-Prot A3N1E1 (G6PI_ACTP2)

Names and origin

Protein names

Recommended name:
    Glucose-6-phosphate isomerase
      Short name=GPI
    EC=5.3.1.9
Alternative name(s):
    Phosphoglucose isomerase
      Short name=PGI
    Phosphohexose isomerase
      Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	APL_1137

Organism

Actinobacillus pleuropneumoniae serotype 5b (strain L20) [Complete proteome] [HAMAP]

Taxonomic identifier

416269 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length	546 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_00473 Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: HAMAP glycolysis Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 546	546	Glucose-6-phosphate isomerase HAMAP MF_00473		PRO_1000013936
Sites
	Active site	353	1	Proton donor By similarity
	Active site	384	1	By similarity
	Active site	512	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A3N1E1-1 [UniParc]. Last modified April 3, 2007. Version 1. Checksum: 6787F092BEE82DEE	FASTA	546	60,415
	10 20 30 40 50 60 MQNINPTQTA AWSALEQHKA DNLNIPQLFA EDANRFDKYH LNFEQQILVD FSKNAINQKT 70 80 90 100 110 120 LELLRQLANE CGLASATEAM FSGQKINRTE NRAVLHTALR NRSNTPVLVD GKDVMPEVNA 130 140 150 160 170 180 VLAKMKDFCE RIISGSWKGY TGKAITDVIN IGIGGSDLGP YMVTEALRPY KNHLNMHFVS 190 200 210 220 230 240 NVDGTHIAEV LKKVNPETTL VLVASKTFTT QETMTNALTA REWLLAAVKD ESAVAKHFAA 250 260 270 280 290 300 LSTNAKEVAK FGIDTANMFE FWDWVGGRYS LWSAIGLSIA LSLGFENFEA LLSGAHAMDN 310 320 330 340 350 360 HFRTAPIEKN IPTTLALIGI WNSNFLGAET EALLPYDQYL HRFAAYFQQG NMESNGKFVG 370 380 390 400 410 420 RDGSPVTHQT GPIVWGEPGT NGQHAFYQLI HQGTKLIPCD FIAPAQTHNP VGDHHAKLLS 430 440 450 460 470 480 NFFAQTEALA FGKSKETVEA EFVAAGKNLA DVAEIVPFKV FTGNKPTNSI LVQKITPFTL 490 500 510 520 530 540 GALIAMYEHK IFVQGVIFNI YSFDQWGVEL GKQLANRILP ELQNAEKISS HDSSTNGLIN QFKAWR

References

[1]	"The complete genome sequence of Actinobacillus pleuropneumoniae L20 (serotype 5b)." Foote S.J., Bosse J.T., Bouevitch A.B., Langford P.R., Young N.M., Nash J.H.E. J. Bacteriol. 190:1495-1496(2008) [PubMed: 18065534] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000569 Genomic DNA. Translation: ABN74227.1.
RefSeq	YP_001053832.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A3N1E1.
Genome annotation databases
GeneID	4849562.
GenomeReviews	Gene locus APL_1137 in contig CP000569_GR.
KEGG	apl:APL_1137.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	GPKIVSQ.
Family and domain databases
HAMAP	MF_00473. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_ACTP2

Accession

Primary (citable) accession number: A3N1E1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	April 3, 2007
Last modified:	November 3, 2009
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)