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A3N1B8 (RLMC_ACTP2) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
23S rRNA (uracil(747)-C(5))-methyltransferase RlmC
EC=2.1.1.189
Alternative name(s):
23S rRNA(m5U747)-methyltransferase
Gene names
Name:rlmC
Ordered Locus Names:APL_1112
OrganismActinobacillus pleuropneumoniae serotype 5b (strain L20) [Complete proteome] [HAMAP]
Taxonomic identifier416269 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus ›

Protein attributes

Sequence length391 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA By similarity. HAMAP-Rule MF_01012

Catalytic activity

S-adenosyl-L-methionine + uracil(747) in 23S rRNA = S-adenosyl-L-homocysteine + 5-methyluracil(747) in 23S rRNA. HAMAP-Rule MF_01012

Sequence similarities

Belongs to the methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 39139123S rRNA (uracil(747)-C(5))-methyltransferase RlmC HAMAP-Rule MF_01012
PRO_0000414815

Sites

Active site3491Nucleophile By similarity
Metal binding51Iron-sulfur (4Fe-4S) By similarity
Metal binding131Iron-sulfur (4Fe-4S) By similarity
Metal binding161Iron-sulfur (4Fe-4S) By similarity
Metal binding951Iron-sulfur (4Fe-4S) By similarity
Binding site2201S-adenosyl-L-methionine By similarity
Binding site2491S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding site2761S-adenosyl-L-methionine By similarity
Binding site3221S-adenosyl-L-methionine By similarity

Sequences

Sequence LengthMass (Da)Tools
A3N1B8 [UniParc].

Last modified April 3, 2007. Version 1.
Checksum: 2C9EC0D1C2A8773C

FASTA39144,153
        10         20         30         40         50         60 
MILNCPHFQQ QDCVSCQWLE KPYATQLTDK EIDLKRLISP FILQNFTEIL PPVQSSQKQF 

        70         80         90        100        110        120 
RNKAKMVVSG SVERPILGIL KDQTDPQSGI DLCDCPLYPT EFEALFPILK DFIARAGLVP 

       130        140        150        160        170        180 
YNISKKKGEL KYILITQSRY NQSIMLRFVL KSEQKRPLVE RELPNLLAKL PKDSVVSLNI 

       190        200        210        220        230        240 
QPQHAAILEG ETEIFLTEKT TIEENFNDIP LFIRPQGFFQ TNPNVASQLY ATAQNWIKDL 

       250        260        270        280        290        300 
AIQQFWDLFC GVGGFGLHCA KALQEKNENV QLTGIEISAS AIASATKSAE QLQLKNITFA 

       310        320        330        340        350        360 
SLDSAQFALN EKSATPDLVI VNPPRRGIGK PLAEFLNQLG TPYLIYSSCN ARTMAQDFEA 

       370        380        390 
LSNYSLQKVQ LFDMFPHTSH YEVLTFLVKK S

« Hide

References

[1]"The complete genome sequence of Actinobacillus pleuropneumoniae L20 (serotype 5b)."
Foote S.J., Bosse J.T., Bouevitch A.B., Langford P.R., Young N.M., Nash J.H.E.
J. Bacteriol. 190:1495-1496(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: L20.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000569 Genomic DNA. Translation: ABN74204.1.
RefSeqYP_001053809.1. NC_009053.1.

3D structure databases

ProteinModelPortalA3N1B8.
ModBaseSearch...

Protein-protein interaction databases

STRING416269.APL_1112.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABN74204; ABN74204; APL_1112.
GeneID4848460.
KEGGapl:APL_1112.
PATRIC20747136. VBIActPle94089_1160.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2265.
HOGENOMHOG000218547.
KOK03212.
OMAQPQHAAI.
ProtClustDBPRK03522.

Enzyme and pathway databases

BioCycAPLE416269:GHV7-1185-MONOMER.

Family and domain databases

HAMAPMF_01012. 23SrRNA_methyltr_RlmC.
InterProIPR011825. 23SrRNA_MeTrfase_RlmC.
IPR010280. U5_MeTrfase.
[Graphical view]
PfamPF05958. tRNA_U5-meth_tr. 1 hit.
[Graphical view]
TIGRFAMsTIGR02085. meth_trns_rumB. 1 hit.
PROSITEPS01230. TRMA_1. 1 hit.
PS01231. TRMA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRLMC_ACTP2
AccessionPrimary (citable) accession number: A3N1B8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: April 3, 2007
Last modified: May 1, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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