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Protein

23S rRNA (uracil(747)-C(5))-methyltransferase RlmC

Gene

rlmC

Organism
Actinobacillus pleuropneumoniae serotype 5b (strain L20)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + uracil(747) in 23S rRNA = S-adenosyl-L-homocysteine + 5-methyluracil(747) in 23S rRNA.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi5Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi13Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi16Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi95Iron-sulfur (4Fe-4S)UniRule annotation1
Binding sitei220S-adenosyl-L-methionineUniRule annotation1
Binding sitei249S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei276S-adenosyl-L-methionineUniRule annotation1
Binding sitei322S-adenosyl-L-methionineUniRule annotation1
Active sitei349NucleophileUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processrRNA processing
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciAPLE416269:G1G87-1161-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
23S rRNA (uracil(747)-C(5))-methyltransferase RlmCUniRule annotation (EC:2.1.1.189UniRule annotation)
Alternative name(s):
23S rRNA(m5U747)-methyltransferaseUniRule annotation
Gene namesi
Name:rlmCUniRule annotation
Ordered Locus Names:APL_1112
OrganismiActinobacillus pleuropneumoniae serotype 5b (strain L20)
Taxonomic identifieri416269 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeActinobacillus
Proteomesi
  • UP000001432 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004148151 – 39123S rRNA (uracil(747)-C(5))-methyltransferase RlmCAdd BLAST391

Interactioni

Protein-protein interaction databases

STRINGi416269.APL_1112

Structurei

3D structure databases

ProteinModelPortaliA3N1B8
SMRiA3N1B8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107SFS Bacteria
COG2265 LUCA
HOGENOMiHOG000218547
KOiK03212
OMAiSCQWLEK

Family and domain databases

HAMAPiMF_01012 23SrRNA_methyltr_RlmC, 1 hit
InterProiView protein in InterPro
IPR011825 23SrRNA_MeTrfase_RlmC
IPR030390 MeTrfase_TrmA_AS
IPR030391 MeTrfase_TrmA_CS
IPR029063 SAM-dependent_MTases
IPR010280 U5_MeTrfase_fam
PANTHERiPTHR11061 PTHR11061, 1 hit
PfamiView protein in Pfam
PF05958 tRNA_U5-meth_tr, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR02085 meth_trns_rumB, 1 hit
PROSITEiView protein in PROSITE
PS51687 SAM_MT_RNA_M5U, 1 hit
PS01230 TRMA_1, 1 hit
PS01231 TRMA_2, 1 hit

Sequencei

Sequence statusi: Complete.

A3N1B8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILNCPHFQQ QDCVSCQWLE KPYATQLTDK EIDLKRLISP FILQNFTEIL
60 70 80 90 100
PPVQSSQKQF RNKAKMVVSG SVERPILGIL KDQTDPQSGI DLCDCPLYPT
110 120 130 140 150
EFEALFPILK DFIARAGLVP YNISKKKGEL KYILITQSRY NQSIMLRFVL
160 170 180 190 200
KSEQKRPLVE RELPNLLAKL PKDSVVSLNI QPQHAAILEG ETEIFLTEKT
210 220 230 240 250
TIEENFNDIP LFIRPQGFFQ TNPNVASQLY ATAQNWIKDL AIQQFWDLFC
260 270 280 290 300
GVGGFGLHCA KALQEKNENV QLTGIEISAS AIASATKSAE QLQLKNITFA
310 320 330 340 350
SLDSAQFALN EKSATPDLVI VNPPRRGIGK PLAEFLNQLG TPYLIYSSCN
360 370 380 390
ARTMAQDFEA LSNYSLQKVQ LFDMFPHTSH YEVLTFLVKK S
Length:391
Mass (Da):44,153
Last modified:April 3, 2007 - v1
Checksum:i2C9EC0D1C2A8773C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000569 Genomic DNA Translation: ABN74204.1
RefSeqiWP_009875490.1, NC_009053.1

Genome annotation databases

EnsemblBacteriaiABN74204; ABN74204; APL_1112
GeneIDi4848460
KEGGiapl:APL_1112
PATRICifig|416269.6.peg.1160

Similar proteinsi

Entry informationi

Entry nameiRLMC_ACTP2
AccessioniPrimary (citable) accession number: A3N1B8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: April 3, 2007
Last modified: May 23, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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