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Protein

23S rRNA (uracil(747)-C(5))-methyltransferase RlmC

Gene

rlmC

Organism
Actinobacillus pleuropneumoniae serotype 5b (strain L20)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + uracil(747) in 23S rRNA = S-adenosyl-L-homocysteine + 5-methyluracil(747) in 23S rRNA.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi5 – 51Iron-sulfur (4Fe-4S)UniRule annotation
Metal bindingi13 – 131Iron-sulfur (4Fe-4S)UniRule annotation
Metal bindingi16 – 161Iron-sulfur (4Fe-4S)UniRule annotation
Metal bindingi95 – 951Iron-sulfur (4Fe-4S)UniRule annotation
Binding sitei220 – 2201S-adenosyl-L-methionineUniRule annotation
Binding sitei249 – 2491S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
Binding sitei276 – 2761S-adenosyl-L-methionineUniRule annotation
Binding sitei322 – 3221S-adenosyl-L-methionineUniRule annotation
Active sitei349 – 3491NucleophileUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciAPLE416269:GHV7-1125-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
23S rRNA (uracil(747)-C(5))-methyltransferase RlmCUniRule annotation (EC:2.1.1.189UniRule annotation)
Alternative name(s):
23S rRNA(m5U747)-methyltransferaseUniRule annotation
Gene namesi
Name:rlmCUniRule annotation
Ordered Locus Names:APL_1112
OrganismiActinobacillus pleuropneumoniae serotype 5b (strain L20)
Taxonomic identifieri416269 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeActinobacillus
Proteomesi
  • UP000001432 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 39139123S rRNA (uracil(747)-C(5))-methyltransferase RlmCPRO_0000414815Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi416269.APL_1112.

Structurei

3D structure databases

ProteinModelPortaliA3N1B8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107SFS. Bacteria.
COG2265. LUCA.
HOGENOMiHOG000218547.
KOiK03212.
OMAiQTNSYAL.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01012. 23SrRNA_methyltr_RlmC. 1 hit.
InterProiIPR011825. 23SrRNA_MeTrfase_RlmC.
IPR030390. MeTrfase_TrmA_AS.
IPR030391. MeTrfase_TrmA_CS.
IPR029063. SAM-dependent_MTases.
IPR010280. U5_MeTrfase_fam.
[Graphical view]
PfamiPF05958. tRNA_U5-meth_tr. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR02085. meth_trns_rumB. 1 hit.
PROSITEiPS51687. SAM_MT_RNA_M5U. 1 hit.
PS01230. TRMA_1. 1 hit.
PS01231. TRMA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3N1B8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILNCPHFQQ QDCVSCQWLE KPYATQLTDK EIDLKRLISP FILQNFTEIL
60 70 80 90 100
PPVQSSQKQF RNKAKMVVSG SVERPILGIL KDQTDPQSGI DLCDCPLYPT
110 120 130 140 150
EFEALFPILK DFIARAGLVP YNISKKKGEL KYILITQSRY NQSIMLRFVL
160 170 180 190 200
KSEQKRPLVE RELPNLLAKL PKDSVVSLNI QPQHAAILEG ETEIFLTEKT
210 220 230 240 250
TIEENFNDIP LFIRPQGFFQ TNPNVASQLY ATAQNWIKDL AIQQFWDLFC
260 270 280 290 300
GVGGFGLHCA KALQEKNENV QLTGIEISAS AIASATKSAE QLQLKNITFA
310 320 330 340 350
SLDSAQFALN EKSATPDLVI VNPPRRGIGK PLAEFLNQLG TPYLIYSSCN
360 370 380 390
ARTMAQDFEA LSNYSLQKVQ LFDMFPHTSH YEVLTFLVKK S
Length:391
Mass (Da):44,153
Last modified:April 3, 2007 - v1
Checksum:i2C9EC0D1C2A8773C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000569 Genomic DNA. Translation: ABN74204.1.
RefSeqiWP_009875490.1. NC_009053.1.

Genome annotation databases

EnsemblBacteriaiABN74204; ABN74204; APL_1112.
GeneIDi4848460.
KEGGiapl:APL_1112.
PATRICi20747136. VBIActPle94089_1160.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000569 Genomic DNA. Translation: ABN74204.1.
RefSeqiWP_009875490.1. NC_009053.1.

3D structure databases

ProteinModelPortaliA3N1B8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi416269.APL_1112.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABN74204; ABN74204; APL_1112.
GeneIDi4848460.
KEGGiapl:APL_1112.
PATRICi20747136. VBIActPle94089_1160.

Phylogenomic databases

eggNOGiENOG4107SFS. Bacteria.
COG2265. LUCA.
HOGENOMiHOG000218547.
KOiK03212.
OMAiQTNSYAL.

Enzyme and pathway databases

BioCyciAPLE416269:GHV7-1125-MONOMER.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01012. 23SrRNA_methyltr_RlmC. 1 hit.
InterProiIPR011825. 23SrRNA_MeTrfase_RlmC.
IPR030390. MeTrfase_TrmA_AS.
IPR030391. MeTrfase_TrmA_CS.
IPR029063. SAM-dependent_MTases.
IPR010280. U5_MeTrfase_fam.
[Graphical view]
PfamiPF05958. tRNA_U5-meth_tr. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR02085. meth_trns_rumB. 1 hit.
PROSITEiPS51687. SAM_MT_RNA_M5U. 1 hit.
PS01230. TRMA_1. 1 hit.
PS01231. TRMA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRLMC_ACTP2
AccessioniPrimary (citable) accession number: A3N1B8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: April 3, 2007
Last modified: September 7, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.