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Protein

Glycerol-3-phosphate acyltransferase

Gene

plsB

Organism
Actinobacillus pleuropneumoniae serotype 5b (strain L20)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate.UniRule annotation

Pathwayi: CDP-diacylglycerol biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glycerol-3-phosphate acyltransferase (plsB)
  2. no protein annotated in this organism
  3. Phosphatidate cytidylyltransferase (cdsA)
This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00557; UER00612.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate acyltransferaseUniRule annotation (EC:2.3.1.15UniRule annotation)
Short name:
GPATUniRule annotation
Gene namesi
Name:plsBUniRule annotation
Ordered Locus Names:APL_1107
OrganismiActinobacillus pleuropneumoniae serotype 5b (strain L20)
Taxonomic identifieri416269 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeActinobacillus
Proteomesi
  • UP000001432 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000494261 – 824Glycerol-3-phosphate acyltransferaseAdd BLAST824

Interactioni

Protein-protein interaction databases

STRINGi416269.APL_1107.

Structurei

3D structure databases

ProteinModelPortaliA3N1B3.
SMRiA3N1B3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi302 – 307HXXXXD motif6

Domaini

The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.UniRule annotation

Sequence similaritiesi

Belongs to the GPAT/DAPAT family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E55. Bacteria.
COG2937. LUCA.
HOGENOMiHOG000218231.
KOiK00631.
OMAiEVIYVPC.

Family and domain databases

HAMAPiMF_00393. Glyc3P_acyltrans. 1 hit.
InterProiView protein in InterPro
IPR022284. GPAT/DHAPAT.
IPR028354. GPAT_PlsB.
IPR002123. Plipid/glycerol_acylTrfase.
PANTHERiPTHR12563. PTHR12563. 1 hit.
PfamiView protein in Pfam
PF01553. Acyltransferase. 1 hit.
PIRSFiPIRSF500064. GPAT. 1 hit.
PIRSF000437. GPAT_DHAPAT. 1 hit.
SMARTiView protein in SMART
SM00563. PlsC. 1 hit.
TIGRFAMsiTIGR03703. plsB. 1 hit.

Sequencei

Sequence statusi: Complete.

A3N1B3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLLNFYRK VLNVPLSLLV KSRAIPTDPV KELNLNLEQP IIYVLPYTSQ
60 70 80 90 100
TDLLILQKNC LSLNLPDPLQ NNELNGQSLP RYVFLDEGRR FFKSKGAKSE
110 120 130 140 150
TESIFYRYLD LHRNNESLDV QLIPASVLWG RSPGKESEPH LRLMSSFQRI
160 170 180 190 200
ISMIWFGRDN FVRFSQALSL KYMVAEHGAD EGIAQKLARV AKIHFAKQRY
210 220 230 240 250
SAMGPRLPDR QAMFNKIIQS PAIKVAIEEE AKTKKISIEK ARQEAEKIVN
260 270 280 290 300
EIAADVSHES LRIADRVLSW LWNKLYQGIN VQNGDRVRKL ALEGHEIVYV
310 320 330 340 350
PCHRSHMDYL LLSYLLYHQG LVPPHIAAGI NLNFFPAGPI FRSWGAFFIR
360 370 380 390 400
RTFKGNRLYS TIFREYLAEL FYRGYSVEYF IEGGRSRTGR LLEPKTGMMS
410 420 430 440 450
MTLQALQRGL TRPISIVPVY IGYEHVLEVD TYAKELRGAE KEKENAGLVL
460 470 480 490 500
RVIKKLKNLG QCYVNFAEPI QVNNYLNQHF PEWKESQAED SRPKWLNEAV
510 520 530 540 550
DSVAHQVMIN INKAAAINAK NLIGSVLLAS RQRALAREQL IEQVDSYLQL
560 570 580 590 600
FKNVSYSDDA IVPNDNAEEM LNHVLTLPRS GVISEKDSFG EMIRLDRESA
610 620 630 640 650
VLMTYYRNNI QHLFVLPSLV ASIILHHESV SKDLIIKTVN RIYPFLKAEL
660 670 680 690 700
FLHFEENDVR NQVEAILTEF SAQRIVKYES DVLQINCVRV RALQLHAAGV
710 720 730 740 750
REILQRYYIS LSILLEHPEI SRAALEKESR SIAQRLSILH GINAPEFFDK
760 770 780 790 800
ALFSTFSASL KAQGYFDSEG NCILEKAKEA EEILRSLISV EVQLTIQGAM
810 820
EKVEEVENTE TVVKTAEAVT EKNE
Length:824
Mass (Da):94,244
Last modified:April 3, 2007 - v1
Checksum:i87574D88EC923FD2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000569 Genomic DNA. Translation: ABN74199.1.
RefSeqiWP_009875486.1. NC_009053.1.

Genome annotation databases

EnsemblBacteriaiABN74199; ABN74199; APL_1107.
GeneIDi4849349.
KEGGiapl:APL_1107.
PATRICifig|416269.6.peg.1155.

Similar proteinsi

Entry informationi

Entry nameiPLSB_ACTP2
AccessioniPrimary (citable) accession number: A3N1B3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: August 30, 2017
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families