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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Actinobacillus pleuropneumoniae serotype 5b (strain L20)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylformylglycinamidine synthase (purL)
  2. Phosphoribosylformylglycinamidine cyclo-ligase (purM)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processPurine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00074; UER00129

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:APL_1095
OrganismiActinobacillus pleuropneumoniae serotype 5b (strain L20)
Taxonomic identifieri416269 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeActinobacillus
Proteomesi
  • UP000001432 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000464161 – 345Phosphoribosylformylglycinamidine cyclo-ligaseAdd BLAST345

Proteomic databases

PRIDEiA3N1A1

Interactioni

Protein-protein interaction databases

STRINGi416269.APL_1095

Structurei

3D structure databases

ProteinModelPortaliA3N1A1
SMRiA3N1A1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CXB Bacteria
COG0150 LUCA
HOGENOMiHOG000229091
KOiK01933
OMAiNHCVNDI

Family and domain databases

CDDicd02196 PurM, 1 hit
Gene3Di3.30.1330.10, 1 hit
3.90.650.10, 1 hit
HAMAPiMF_00741 AIRS, 1 hit
InterProiView protein in InterPro
IPR010918 PurM-like_C_dom
IPR036676 PurM-like_C_sf
IPR016188 PurM-like_N
IPR036921 PurM-like_N_sf
IPR004733 PurM_cligase
PANTHERiPTHR10520 PTHR10520, 1 hit
PfamiView protein in Pfam
PF00586 AIRS, 1 hit
PF02769 AIRS_C, 1 hit
SUPFAMiSSF55326 SSF55326, 1 hit
SSF56042 SSF56042, 1 hit
TIGRFAMsiTIGR00878 purM, 1 hit

Sequencei

Sequence statusi: Complete.

A3N1A1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNTQLSYKD AGVDIHAGNE LVERIKGDVK RTRRPEVMGG LGGFGALCAL
60 70 80 90 100
PTKYKEPILV SGTDGVGTKL RLAIDLNKHD TIGQDLVAMC VNDLVVQGAE
110 120 130 140 150
PLFFLDYYAT GKLEVDVAAD VIKGIADGCE ISGCALVGGE TAEMPGMYHE
160 170 180 190 200
GDYDLAGFCV GVVEKSEIID GSAVKAGDVL LALASSGPHS NGYSLIRKVI
210 220 230 240 250
EVSGANPATD TLEGKPLSEH LLAPTKIYVK SVLQLIKQAD VHAIAHLTGG
260 270 280 290 300
GFWENIPRVL PATAKAVIDE KSWEWPAAFK WLQEKGNISR YEMYRTFNCG
310 320 330 340
VGMVIALPEK DIETALAVLK QAGENAWVIG KIENLGEGSE QVEII
Length:345
Mass (Da):36,867
Last modified:April 3, 2007 - v1
Checksum:iEFFC3A21C33411CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000569 Genomic DNA Translation: ABN74187.1
RefSeqiWP_005597960.1, NC_009053.1

Genome annotation databases

EnsemblBacteriaiABN74187; ABN74187; APL_1095
GeneIDi4850427
KEGGiapl:APL_1095

Similar proteinsi

Entry informationi

Entry nameiPUR5_ACTP2
AccessioniPrimary (citable) accession number: A3N1A1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: May 23, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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