Reviewed, UniProtKB/Swiss-Prot A3N123 (DEOC_ACTP2)

Names and origin

Protein names

Recommended name:
    Deoxyribose-phosphate aldolase
    EC=4.1.2.4
Alternative name(s):
    Phosphodeoxyriboaldolase
      Short name=Deoxyriboaldolase
      Short name=DERA

Gene names

Name:	deoC
Ordered Locus Names:	APL_1015

Organism

Actinobacillus pleuropneumoniae serotype 5b (strain L20) [Complete proteome] [HAMAP]

Taxonomic identifier

416269 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length	258 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. HAMAP MF_00592
Pathway	Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2. HAMAP MF_00592
Subcellular location	Cytoplasm By similarity HAMAP MF_00592.
Sequence similarities	Belongs to the deoC/fbaB aldolase family. DeoC type 2 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate catabolic process Inferred from electronic annotation. Source: HAMAP deoxyribonucleotide catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	deoxyribose-phosphate aldolase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 258	258	Deoxyribose-phosphate aldolase HAMAP MF_00592		PRO_1000072591
Sites
	Active site	166	1	Schiff-base intermediate with acetaldehyde By similarity
	Active site	200	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A3N123-1 [UniParc]. Last modified April 3, 2007. Version 1. Checksum: C2E9E0BC72CA1D54	FASTA	258	27,680
	10 20 30 40 50 60 MSLKDSAKIA LSLMDLTTLN DNDTDEKVIT LCQQGKTEFG TPAAVCVYPR FVPIARKALK 70 80 90 100 110 120 AQGTEQVKIA TVTNFPHGNN DIDIAVAETK AAVAYGADEV DVVFPYKALM AGNEQIGFEL 130 140 150 160 170 180 VQQCKAVCQA SNVLLKVIIE TGELKTAELI RKASEISIKA GADFIKTSTG KVPVNATLEY 190 200 210 220 230 240 ARIMLETIRD LNVADRVGFK AAGGVKTAEE AAQYLALAQE ILGHDWVNSD HFRFGASSLL 250 TNLLAALNGQ ANQKVSGY

References

[1]	"The complete genome sequence of Actinobacillus pleuropneumoniae L20 (serotype 5b)." Foote S.J., Bosse J.T., Bouevitch A.B., Langford P.R., Young N.M., Nash J.H.E. J. Bacteriol. 190:1495-1496(2008) [PubMed: 18065534] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000569 Genomic DNA. Translation: ABN74109.1.
RefSeq	YP_001053714.1.
3D structure databases
SMR	A3N123. Positions 3-235.
ModBase	Search...
Protein-protein interaction databases
STRING	A3N123.
Genome annotation databases
GeneID	4849634.
GenomeReviews	Gene locus APL_1015 in contig CP000569_GR.
KEGG	apl:APL_1015.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0274.
HOGENOM	HBG636421.
OMA	NEQIGFE.
PhylomeDB	A3N123.
Family and domain databases
HAMAP	MF_00592. DeoC_type2. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR011343. DeoC. IPR002915. DeoC/AroFGH_arch. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHER	PTHR10889. DeoC. 1 hit.
Pfam	PF01791. DeoC. 1 hit. [Graphical view]
PIRSF	PIRSF001357. DeoC. 1 hit.
TIGRFAMs	TIGR00126. deoC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DEOC_ACTP2

Accession

Primary (citable) accession number: A3N123

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	April 3, 2007
Last modified:	February 9, 2010
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)