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Protein

60 kDa chaperonin

Gene

groL

Organism
Actinobacillus pleuropneumoniae serotype 5b (strain L20)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperoninUniRule annotation
Alternative name(s):
GroEL proteinUniRule annotation
Protein Cpn60UniRule annotation
Gene namesi
Name:groLUniRule annotation
Synonyms:groELUniRule annotation
Ordered Locus Names:APL_1012
OrganismiActinobacillus pleuropneumoniae serotype 5b (strain L20)
Taxonomic identifieri416269 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeActinobacillus
Proteomesi
  • UP000001432 Componenti: Chromosome

Subcellular locationi

A3N120:
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000257471 – 54760 kDa chaperoninAdd BLAST547

Proteomic databases

PRIDEiA3N120.

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation

Protein-protein interaction databases

STRINGi416269.APL_1012.

Structurei

3D structure databases

ProteinModelPortaliA3N120.
SMRiA3N120.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ9. Bacteria.
COG0459. LUCA.
HOGENOMiHOG000076290.
KOiK04077.
OMAiTDTDKME.

Family and domain databases

CDDicd03344. GroEL. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiView protein in InterPro
IPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
PANTHERiPTHR11353. PTHR11353. 1 hit.
PfamiView protein in Pfam
PF00118. Cpn60_TCP1. 1 hit.
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF48592. SSF48592. 2 hits.
SSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiView protein in PROSITE
PS00296. CHAPERONINS_CPN60. 1 hit.

Sequencei

Sequence statusi: Complete.

A3N120-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAKDVKFGN DARVKMLKGV NVLADAVKVT LGPKGRNVVL DKAYGAPTIT
60 70 80 90 100
KDGVSVAREI ELEDKFENMG AQMVKEVASK ANDAAGDGTT TATVLAQAIV
110 120 130 140 150
NEGLKAVAAG MNPMDLKRGI DKAVVAVVEE LKAISKPCET SKEIEQVGTI
160 170 180 190 200
SANSDETVGK LIAQAMEKVG KEGVITVEDG TGLDDALDVV EGMQFDRGYL
210 220 230 240 250
SPYFINKPEA GTVELENPYI ILVDKKISNI REILPVLEAV AKAGKPLLIV
260 270 280 290 300
AEDIEGEALA TLVVNTMRGI VKVAAVKAPG FGDRRKAMLQ DIAILTAGTV
310 320 330 340 350
ISEEIGMELE KATLEELGQA KRVVITKDNT TIIDGIGDEA QIKARVAQIR
360 370 380 390 400
QQIEDSTSDY DKEKLQERVA KLACGVAVIK VGAATEVAMK EKKDRVDDAL
410 420 430 440 450
HATRAAVEEG IVPGGGVALV RAASKVAATL TGDNEEQNVG IKLALRAMEA
460 470 480 490 500
PLRQIVTNAG EEASVVARNV KDGNGNYGYN AGTEQYGDML EMGILDPTKV
510 520 530 540
TRSALQFAAS IAGLMITTEC MITDLPKEEK LDPAAAMGGM GGMGGMI
Length:547
Mass (Da):57,646
Last modified:April 3, 2007 - v1
Checksum:iE0300C0BF41BEF15
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000569 Genomic DNA. Translation: ABN74106.1.
RefSeqiWP_009874825.1. NC_009053.1.

Genome annotation databases

EnsemblBacteriaiABN74106; ABN74106; APL_1012.
GeneIDi4849874.
KEGGiapl:APL_1012.
PATRICifig|416269.6.peg.1059.

Similar proteinsi

Entry informationi

Entry nameiCH60_ACTP2
AccessioniPrimary (citable) accession number: A3N120
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: October 25, 2017
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families