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A3N0N2

- SYL_ACTP2

UniProt

A3N0N2 - SYL_ACTP2

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Actinobacillus pleuropneumoniae serotype 5b (strain L20)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei622 – 6221ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAPLE416269:GHV7-885-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:APL_0872
OrganismiActinobacillus pleuropneumoniae serotype 5b (strain L20)
Taxonomic identifieri416269 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeActinobacillus
ProteomesiUP000001432: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 861861Leucine--tRNA ligasePRO_1000009286Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi416269.APL_0872.

Structurei

3D structure databases

ProteinModelPortaliA3N0N2.
SMRiA3N0N2. Positions 228-413.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi619 – 6235"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3N0N2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQQQYNPSAI EPKVQQFWAE NKVFKAVKDV TKEKYYCLSM LPYPSGKLHM
60 70 80 90 100
GHVRNYTIGD VVSRYQRMIG KNVLQPMGWD AFGLPAEGAA VKNNTAPAKW
110 120 130 140 150
TYENIEYMKG QLKMLGFSYD WDREVTTCRP EYYKWEQWFF TELYKKGLVY
160 170 180 190 200
KKTSTVNWCP NDATVLANEQ VHEGCCWRCD TPVEQREIPQ WFIKITDYAE
210 220 230 240 250
ELLTHLDNLP QWPDQVKTMQ RNWIGRSEGV EITFKIAGSN AELPVYTTRP
260 270 280 290 300
DTFFGVSYVA IAAAHPLAEM AAENNPALAE FIREAKNTKV AEAELATMEK
310 320 330 340 350
KGMATGLFAI HPLTGKEVPV WVANFVLMHY GTGAVMAVPA HDERDFEFAQ
360 370 380 390 400
KYGLQINQVI QPLDGSEWDF SKAAYTEHGK LINSAEFDDL NFEQAFNAIA
410 420 430 440 450
DKLESMKVGK RQVNFRLRDW GVSRQRYWGA PIPMMTTEDG EVVTVPMQDL
460 470 480 490 500
PVILPEDVVM NGVQSPIKAD PEWAKTTYNG KPALKETDTF DTFMESSWYY
510 520 530 540 550
ARYTCPQYHE GMLDSDEANY WLPVDQYIGG IEHATMHLLY FRFFHKLLRD
560 570 580 590 600
AGILNSDEPA TKLLCQGMVL ADAFYYTSPT NERIWVSPTQ VTLERDEKGR
610 620 630 640 650
IIKATDPEGR ELVHSGMTKM SKSKNNGIDP QEMVEKYGAD TVRLFMMFAS
660 670 680 690 700
PAEMTLEWQE SGVEGAKRFL GRVWNLVYEY SQNPATAALD VAALSKAQKE
710 720 730 740 750
LRRDVHKTIA KVSDDIGRRQ TFNTAIAAIM ELMNKLTKAP LENEQDKAVM
760 770 780 790 800
AEALSAVVRM LYPITPHICF ELWQALGNND TIDFAPWVVA DESAMVEDEK
810 820 830 840 850
LVVVQVNGKV RGKVTVSATA TEDEVKAIAK ADANVAKFLE GVEIVKEIYV
860
PYKMLSFAVK A
Length:861
Mass (Da):97,751
Last modified:April 3, 2007 - v1
Checksum:i3F8A8665AFF303D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000569 Genomic DNA. Translation: ABN73968.1.
RefSeqiYP_001053573.1. NC_009053.1.

Genome annotation databases

EnsemblBacteriaiABN73968; ABN73968; APL_0872.
GeneIDi4849039.
KEGGiapl:APL_0872.
PATRICi20746632. VBIActPle94089_0911.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000569 Genomic DNA. Translation: ABN73968.1 .
RefSeqi YP_001053573.1. NC_009053.1.

3D structure databases

ProteinModelPortali A3N0N2.
SMRi A3N0N2. Positions 228-413.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 416269.APL_0872.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABN73968 ; ABN73968 ; APL_0872 .
GeneIDi 4849039.
KEGGi apl:APL_0872.
PATRICi 20746632. VBIActPle94089_0911.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci APLE416269:GHV7-885-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Actinobacillus pleuropneumoniae L20 (serotype 5b)."
    Foote S.J., Bosse J.T., Bouevitch A.B., Langford P.R., Young N.M., Nash J.H.E.
    J. Bacteriol. 190:1495-1496(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: L20.

Entry informationi

Entry nameiSYL_ACTP2
AccessioniPrimary (citable) accession number: A3N0N2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: October 29, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3