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Protein

dCTP deaminase

Gene

dcd

Organism
Actinobacillus pleuropneumoniae serotype 5b (strain L20)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the deamination of dCTP to dUTP.UniRule annotation

Catalytic activityi

dCTP + H2O = dUTP + NH3.UniRule annotation

Pathwayi: dUMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes dUMP from dCTP (dUTP route).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. dCTP deaminase (dcd)
  2. Deoxyuridine 5'-triphosphate nucleotidohydrolase (dut)
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP (dUTP route), the pathway dUMP biosynthesis and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei128dCTPUniRule annotation1
Active sitei138Proton donor/acceptorUniRule annotation1
Binding sitei171dCTPUniRule annotation1
Binding sitei178dCTPUniRule annotation1
Binding sitei182dCTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi110 – 115dCTP bindingUniRule annotation6
Nucleotide bindingi136 – 138dCTP bindingUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandNucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00610; UER00665

Names & Taxonomyi

Protein namesi
Recommended name:
dCTP deaminaseUniRule annotation (EC:3.5.4.13UniRule annotation)
Alternative name(s):
Deoxycytidine triphosphate deaminaseUniRule annotation
Gene namesi
Name:dcdUniRule annotation
Ordered Locus Names:APL_0835
OrganismiActinobacillus pleuropneumoniae serotype 5b (strain L20)
Taxonomic identifieri416269 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeActinobacillus
Proteomesi
  • UP000001432 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000096721 – 194dCTP deaminaseAdd BLAST194

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi416269.APL_0835

Structurei

3D structure databases

ProteinModelPortaliA3N0J5
SMRiA3N0J5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dCTP deaminase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DHP Bacteria
COG0717 LUCA
HOGENOMiHOG000228601
KOiK01494
OMAiGWIDAGF

Family and domain databases

CDDicd07557 trimeric_dUTPase, 1 hit
Gene3Di2.70.40.10, 1 hit
HAMAPiMF_00146 dCTP_deaminase, 1 hit
InterProiView protein in InterPro
IPR010550 dCTP_deam_bac
IPR011962 dCTP_deaminase
IPR036157 dUTPase-like_sf
IPR033704 dUTPase_trimeric
PfamiView protein in Pfam
PF06559 DCD, 1 hit
SUPFAMiSSF51283 SSF51283, 1 hit
TIGRFAMsiTIGR02274 dCTP_deam, 1 hit

Sequencei

Sequence statusi: Complete.

A3N0J5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLCDTDIER YLDEGIIEII PRPSNEKITG ATVDVRLGNS FRVFREHATP
60 70 80 90 100
YIDLSGPREE VTAQLHKVMS EEIIIADGEA FFLHPGELAL ATTLESVTLP
110 120 130 140 150
DNVVGWLDGR SSLARLGLMV HVTAHRIDPG WQGKIVLEFF NAGKLPLALR
160 170 180 190
PNMAIGALSF EILSGHAAKP YNARKDAKYK NQQSAVSSRI NQDD
Length:194
Mass (Da):21,476
Last modified:April 3, 2007 - v1
Checksum:iF3E7DD3222E34047
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000569 Genomic DNA Translation: ABN73931.1
RefSeqiWP_005597311.1, NC_009053.1

Genome annotation databases

EnsemblBacteriaiABN73931; ABN73931; APL_0835
GeneIDi4849342
KEGGiapl:APL_0835

Similar proteinsi

Entry informationi

Entry nameiDCD_ACTP2
AccessioniPrimary (citable) accession number: A3N0J5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: April 25, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health