Reviewed, UniProtKB/Swiss-Prot A3N063 (AROA_ACTP2)

Names and origin

Protein names

Recommended name:
    3-phosphoshikimate 1-carboxyvinyltransferase
    EC=2.5.1.19
Alternative name(s):
    5-enolpyruvylshikimate-3-phosphate synthase
      Short name=EPSP synthase
      Short name=EPSPS

Gene names

Name:	aroA
Ordered Locus Names:	APL_0699

Organism

Actinobacillus pleuropneumoniae serotype 5b (strain L20) [Complete proteome] [HAMAP]

Taxonomic identifier

416269 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length	432 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 432	432	3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210		PRO_1000012405

Sequences

	Sequence		Length	Mass (Da)
	A3N063-1 [UniParc]. Last modified April 3, 2007. Version 1. Checksum: DED9B435A8FD4B2A	FASTA	432	46,910
	10 20 30 40 50 60 MEKITLAPIS RVEGEINLPG SKSLSNRALL LAALAKGTTK VTNLLDSDDI RHMLNALKAL 70 80 90 100 110 120 GVNYSLSEDK TVCTVEGVGG AFNWKNGLAL FLGNAGTAMR PLTAALCLKG SSEAEVVLTG 130 140 150 160 170 180 EPRMKERPIK HLVDALRQAG ASVQYLENEG YPPVAIRNSG LKGGKVQIDG SISSQFLTAL 190 200 210 220 230 240 LMAAPLAEGD MEIEIIGELV SKPYIDITLA MMKDFGVKVE NRNYQTFVVK GNQSYLSPEK 250 260 270 280 290 300 YLVEGDASSA SYFLAAGAIK GKVKVTGIGK NSIQGDRLFA NVLEAMGAKI TWGDDFIQAE 310 320 330 340 350 360 QGKLKGVDMD MNHIPDAAMT IATAALFAEG ETVIRNIYNW RVKETDRLTA MATELRKVGA 370 380 390 400 410 420 TVEEGEDFIR IQPLPLTQFQ HAEIATYNDH RMAMCFSLIA LSDTPVTILD PKCTAKTFPT 430 YFTEFEKLSE RT

References

[1]	"The complete genome sequence of Actinobacillus pleuropneumoniae L20 (serotype 5b)." Foote S.J., Bosse J.T., Bouevitch A.B., Langford P.R., Young N.M., Nash J.H.E. J. Bacteriol. 190:1495-1496(2008) [PubMed: 18065534] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000569 Genomic DNA. Translation: ABN73799.1.
RefSeq	YP_001053404.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A3N063.
Genome annotation databases
GeneID	4848647.
GenomeReviews	Gene locus APL_0699 in contig CP000569_GR.
KEGG	apl:APL_0699.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	EIDTYND.
Family and domain databases
HAMAP	MF_00210. [Tree]
InterPro	IPR016228. EPSP_synthase. IPR001986. EPSP_synthase_core. IPR006264. EPSP_synthase_subgroup. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 1 hit.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
ProDom	PD001867. EPSP_synth. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01356. aroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. 1 hit. PS00885. EPSP_SYNTHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA_ACTP2

Accession

Primary (citable) accession number: A3N063

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	April 3, 2007
Last modified:	November 3, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)