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A3N063 (AROA_ACTP2) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-phosphoshikimate 1-carboxyvinyltransferase
EC=2.5.1.19
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS
Gene names
Name:aroA
Ordered Locus Names:APL_0699
OrganismActinobacillus pleuropneumoniae serotype 5b (strain L20) [Complete proteome] [HAMAP]
Taxonomic identifier416269 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length432 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210

Subunit structure

Monomer By similarity. HAMAP MF_00210

Subcellular location

Cytoplasm By similarity HAMAP MF_00210.

Sequence similarities

Belongs to the EPSP synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-phosphoshikimate 1-carboxyvinyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4324323-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210
PRO_1000012405

Sequences

Sequence LengthMass (Da)Tools
A3N063 [UniParc].

Last modified April 3, 2007. Version 1.
Checksum: DED9B435A8FD4B2A

FASTA43246,910
        10         20         30         40         50         60 
MEKITLAPIS RVEGEINLPG SKSLSNRALL LAALAKGTTK VTNLLDSDDI RHMLNALKAL 

        70         80         90        100        110        120 
GVNYSLSEDK TVCTVEGVGG AFNWKNGLAL FLGNAGTAMR PLTAALCLKG SSEAEVVLTG 

       130        140        150        160        170        180 
EPRMKERPIK HLVDALRQAG ASVQYLENEG YPPVAIRNSG LKGGKVQIDG SISSQFLTAL 

       190        200        210        220        230        240 
LMAAPLAEGD MEIEIIGELV SKPYIDITLA MMKDFGVKVE NRNYQTFVVK GNQSYLSPEK 

       250        260        270        280        290        300 
YLVEGDASSA SYFLAAGAIK GKVKVTGIGK NSIQGDRLFA NVLEAMGAKI TWGDDFIQAE 

       310        320        330        340        350        360 
QGKLKGVDMD MNHIPDAAMT IATAALFAEG ETVIRNIYNW RVKETDRLTA MATELRKVGA 

       370        380        390        400        410        420 
TVEEGEDFIR IQPLPLTQFQ HAEIATYNDH RMAMCFSLIA LSDTPVTILD PKCTAKTFPT 

       430 
YFTEFEKLSE RT

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References

[1]"The complete genome sequence of Actinobacillus pleuropneumoniae L20 (serotype 5b)."
Foote S.J., Bosse J.T., Bouevitch A.B., Langford P.R., Young N.M., Nash J.H.E.
J. Bacteriol. 190:1495-1496(2008) [PubMed: 18065534] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: L20.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000569 Genomic DNA. Translation: ABN73799.1.
RefSeqYP_001053404.1. NC_009053.1.

3D structure databases

ProteinModelPortalA3N063.
ModBaseSearch...

Protein-protein interaction databases

STRINGA3N063.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4848647.
GenomeReviewsGene locus APL_0699 in contig CP000569_GR.
KEGGapl:APL_0699.
PATRIC20746264. VBIActPle94089_0733.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0128.
HOGENOMHBG646626.
OMAGADIEWG.
PhylomeDBA3N063.
ProtClustDBPRK02427.

Enzyme and pathway databases

BioCycAPLE416269:APL_0699-MONOMER.

Family and domain databases

HAMAPMF_00210. EPSP_synth.
[Tree]
InterProIPR001986. Enolpyruvate_Tfrase_dom.
IPR006264. EPSP_synthase.
IPR023193. EPSP_synthase_CS.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
[Graphical view]
Gene3DG3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KOK00800.
PfamPF00275. EPSP_synthase. 1 hit.
[Graphical view]
PIRSFPIRSF000505. EPSPS. 1 hit.
SUPFAMSSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMsTIGR01356. AroA. 1 hit.
PROSITEPS00104. EPSP_SYNTHASE_1. 1 hit.
PS00885. EPSP_SYNTHASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROA_ACTP2
AccessionPrimary (citable) accession number: A3N063
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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