Reviewed, UniProtKB/Swiss-Prot A3N048 (DAPB_ACTP2)

Names and origin

Protein names

Recommended name:
    Dihydrodipicolinate reductase
      Short name=DHPR
    EC=1.3.1.26

Gene names

Name:	dapB
Ordered Locus Names:	APL_0684

Organism

Actinobacillus pleuropneumoniae serotype 5b (strain L20) [Complete proteome] [HAMAP]

Taxonomic identifier

416269 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length	269 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2,3,4,5-tetrahydrodipicolinate + NAD(P)(+) = 2,3-dihydrodipicolinate + NAD(P)H.
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; tetrahydrodipicolinate from L-aspartate: step 4/4.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the dihydrodipicolinate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	binding Inferred from electronic annotation. Source: InterPro dihydrodipicolinate reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 269	269	Dihydrodipicolinate reductase		PRO_1000008530

Sequences

	Sequence		Length	Mass (Da)
	A3N048-1 [UniParc]. Last modified April 3, 2007. Version 1. Checksum: 13A5AD0DC7E1C752	FASTA	269	28,701
	10 20 30 40 50 60 MTLKIGIVGA GGRMGRNLIT AVQNAEGVEL GAAFERKGSS LVGADAGEVA GIGATGVKIS 70 80 90 100 110 120 DDLNQNTNFD VLIDFTRPEG TLEHIKFCVA NGKKMVIGTT GFDDAGKQAI QTAAEQISIV 130 140 150 160 170 180 FASNYSVGVN LVFKLLEKAA KVMGDYCDIE VIEAHHRHKV DAPSGTALSM GEHIAKTLGR 190 200 210 220 230 240 DLKTHGVFAR EGITGERKRD EIGFATIRAG DVVGEHSVWF ADEGERVEIA HKASSRMTFA 250 260 NGAVRAAKWL NTKQNGLFDM TDVLDLNNL

References

[1]	"The complete genome sequence of Actinobacillus pleuropneumoniae L20 (serotype 5b)." Foote S.J., Bosse J.T., Bouevitch A.B., Langford P.R., Young N.M., Nash J.H.E. J. Bacteriol. 190:1495-1496(2008) [PubMed: 18065534] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000569 Genomic DNA. Translation: ABN73784.1.
RefSeq	YP_001053389.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4849484.
GenomeReviews	Gene locus APL_0684 in contig CP000569_GR.
KEGG	apl:APL_0684.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00102. [Tree]
InterPro	IPR000846. DapB. IPR011770. DapB_bac/pln. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 2 hits.
PANTHER	PTHR20836. DapB_bac/pln. 1 hit.
Pfam	PF05173. DapB_C. 1 hit. PF01113. DapB_N. 1 hit. [Graphical view]
ProDom	PD004105. DapB. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00036. dapB. 1 hit.
PROSITE	PS01298. DAPB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPB_ACTP2

Accession

Primary (citable) accession number: A3N048

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	April 3, 2007
Last modified:	November 25, 2008
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)