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A3N039 (SYN_ACTP2) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Asparagine--tRNA ligase
EC=6.1.1.22
Alternative name(s):
Asparaginyl-tRNA synthetase
Short name=AsnRS
Gene names
Name:asnS
Ordered Locus Names:APL_0675
OrganismActinobacillus pleuropneumoniae serotype 5b (strain L20) [Complete proteome] [HAMAP]
Taxonomic identifier416269 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length467 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn). HAMAP MF_00534

Subunit structure

Homodimer By similarity. HAMAP MF_00534

Subcellular location

Cytoplasm HAMAP MF_00534.

Sequence similarities

Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processasparaginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

asparagine-tRNA ligase activity

Inferred from electronic annotation. Source: EC

nucleic acid binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 467467Asparagine--tRNA ligase HAMAP MF_00534
PRO_1000051373

Sequences

Sequence LengthMass (Da)Tools
A3N039 [UniParc].

Last modified April 3, 2007. Version 1.
Checksum: 6EAEDBAEF1446C92

FASTA46752,727
        10         20         30         40         50         60 
MSKFPTVSEI LSGKVAVGEE VAVRGWVRTR RDSKAGLSFL AVYDGSCFDP IQSIINNDLA 

        70         80         90        100        110        120 
NYNDEVLRLT AGCSVIVTGK VVESPAEGQA VELHATHVEV VGWVEDPDTY PMAAKRHSIE 

       130        140        150        160        170        180 
YLREVAHLRP RTNLIGAVAR VRHCLAQAIH RFFNEQGFYW VATPLITASD TEGAGEMFRV 

       190        200        210        220        230        240 
STLDLENLPR TEEGKVDFSQ DFFGKESFLT VSGQLNGETY ACALSKVYTF GPTFRAENSN 

       250        260        270        280        290        300 
TTRHLAEFWM VEPEFAFATL ADNAKLAEDM LKYVFKAVLE ERKDDMQFFA KHIDKDVITR 

       310        320        330        340        350        360 
LENFIAAPFA QVDYTDAIEI LLKSGKEFEF PVSWGIDLSS EHERFLAEEY FKSPVVVKNY 

       370        380        390        400        410        420 
PKDIKAFYMR LNDDGKTVAA MDVLAPGIGE IIGGSQREER LDVLDTRMVE MGLNPEDYWW 

       430        440        450        460 
YRDLRKYGTV PHSGFGLGFE RLIVYVTGLQ NIREVIPFPR APRNANF

« Hide

References

[1]"The complete genome sequence of Actinobacillus pleuropneumoniae L20 (serotype 5b)."
Foote S.J., Bosse J.T., Bouevitch A.B., Langford P.R., Young N.M., Nash J.H.E.
J. Bacteriol. 190:1495-1496(2008) [PubMed: 18065534] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: L20.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000569 Genomic DNA. Translation: ABN73775.1.
RefSeqYP_001053380.1. NC_009053.1.

3D structure databases

ProteinModelPortalA3N039.
ModBaseSearch...

Protein-protein interaction databases

STRINGA3N039.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4850404.
GenomeReviewsGene locus APL_0675 in contig CP000569_GR.
KEGGapl:APL_0675.
PATRIC20746210. VBIActPle94089_0706.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0017.
HOGENOMHBG745843.
OMAAIHRFFH.
PhylomeDBA3N039.
ProtClustDBPRK03932.

Enzyme and pathway databases

BioCycAPLE416269:APL_0675-MONOMER.

Family and domain databases

HAMAPMF_00534. Asn_tRNA_synth.
[Tree]
InterProIPR004364. aa-tRNA-synt_II.
IPR018150. aa-tRNA-synt_II-like.
IPR006195. aa-tRNA-synth_II.
IPR004522. Asn-tRNA-synth_IIb.
IPR002312. Asp/Asn-tRNA-synth_IIb.
IPR012340. NA-bd_OB-fold.
IPR016027. NA-bd_OB-fold-like.
IPR004365. NA-bd_OB_tRNA-helicase.
[Graphical view]
Gene3DG3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit.
KOK01893.
PANTHERPTHR22594. aa-tRNA-synt_II. 1 hit.
PTHR22594:SF6. PTHR22594:SF6. 1 hit.
PfamPF00152. tRNA-synt_2. 1 hit.
PF01336. tRNA_anti. 1 hit.
[Graphical view]
PRINTSPR01042. TRNASYNTHASP.
SUPFAMSSF50249. Nucleic_acid_OB. 1 hit.
TIGRFAMsTIGR00457. AsnS. 1 hit.
PROSITEPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYN_ACTP2
AccessionPrimary (citable) accession number: A3N039
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries

SIMILARITY comments

Index of protein domains and families

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