Reviewed, UniProtKB/Swiss-Prot A3N011 (ACKA_ACTP2)

Names and origin

Protein names

Recommended name:
    Acetate kinase
    EC=2.7.2.1
Alternative name(s):
    Acetokinase

Gene names

Name:	ackA
Ordered Locus Names:	APL_0645

Organism

Actinobacillus pleuropneumoniae serotype 5b (strain L20) [Complete proteome] [HAMAP]

Taxonomic identifier

416269 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length	402 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + acetate = ADP + acetyl phosphate. HAMAP MF_00020 ATP + propanoate = ADP + propanoyl phosphate. HAMAP MF_00020
Pathway	Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2. HAMAP MF_00020
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the acetokinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	organic acid metabolic process Inferred from electronic annotation. Source: InterPro phosphorylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 402	402	Acetate kinase HAMAP MF_00020		PRO_1000002204

Sequences

	Sequence		Length	Mass (Da)
	A3N011-1 [UniParc]. Last modified April 3, 2007. Version 1. Checksum: F2602BACCD1866D9	FASTA	402	43,583
	10 20 30 40 50 60 MSKNLILILN CGSSSLKFAV LDPKTGDEKL SGLAEAFNLE DARIKWKLHG EKGNADLGAG 70 80 90 100 110 120 AAHSEALTFI ANELLSEELR SSIGAIGHRI VHGGEQFTSS VVINDDVVKG IEHAIQFAPL 130 140 150 160 170 180 HNPAHLIGIK EAFRIFPELK EKNVAVFDTA FHQTMPEEAF LYALPYKLYK EHGIRRYGAH 190 200 210 220 230 240 GTSHLFITSQ VAELAGKPVD QTNAIICHLG NGGSVSVVRN GKCIDTSMGL TPLEGLVMGT 250 260 270 280 290 300 RSGDIDPAIV FYLYKNLGMS MEQIEDTLVK KSGLLGLTEV TSDCRYAEDN YEDASKPEAK 310 320 330 340 350 360 RALDVYSYRL AKYIGAYMAI LGDDHLDAIA FTGGIGENSG HVRELALNHL KLFGVKLDVE 370 380 390 400 RNLAARFGKS GVITADDSTF KAVVIPTNEE LVIAQDTAKL AL

References

[1]	"The complete genome sequence of Actinobacillus pleuropneumoniae L20 (serotype 5b)." Foote S.J., Bosse J.T., Bouevitch A.B., Langford P.R., Young N.M., Nash J.H.E. J. Bacteriol. 190:1495-1496(2008) [PubMed: 18065534] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000569 Genomic DNA. Translation: ABN73747.1.
RefSeq	YP_001053352.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A3N011.
Genome annotation databases
GeneID	4848842.
GenomeReviews	Gene locus APL_0645 in contig CP000569_GR.
KEGG	apl:APL_0645.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	PHLKDKN.
Family and domain databases
HAMAP	MF_00020. [Tree]
InterPro	IPR000890. Acetate/butyrate_kinase. IPR004372. AckA. [Graphical view]
PANTHER	PTHR21060. Acetate_kin. 1 hit. PTHR21060:SF11. AckA. 1 hit.
Pfam	PF00871. Acetate_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000722. Acetate_prop_kin. 1 hit.
PRINTS	PR00471. ACETATEKNASE.
TIGRFAMs	TIGR00016. ackA. 1 hit.
PROSITE	PS01075. ACETATE_KINASE_1. 1 hit. PS01076. ACETATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACKA_ACTP2

Accession

Primary (citable) accession number: A3N011

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	April 3, 2007
Last modified:	November 3, 2009
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)