Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A3MZI4

- FTHS_ACTP2

UniProt

A3MZI4 - FTHS_ACTP2

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Actinobacillus pleuropneumoniae serotype 5b (strain L20)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi64 – 718ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAPLE416269:GHV7-476-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:APL_0466
OrganismiActinobacillus pleuropneumoniae serotype 5b (strain L20)
Taxonomic identifieri416269 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeActinobacillus
ProteomesiUP000001432: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Formate--tetrahydrofolate ligasePRO_0000300513Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi416269.APL_0466.

Structurei

3D structure databases

ProteinModelPortaliA3MZI4.
SMRiA3MZI4. Positions 4-554.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiGIEHEAS.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3MZI4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKSDVEIAQA ATMQPIHKIA EKLGLNADQI EQYGKYKAKI NPTDAFKLPA
60 70 80 90 100
KNGKLILVTA INPTPAGEGK TTVTIGLTDA LNQLGKNAVV AAREPSLGPV
110 120 130 140 150
FGVKGGAAGG GYAQVLPMED INLHFTGDFH AITSANNLLA ALLDNHIYQG
160 170 180 190 200
NALNIDTKRV LWRRVIDMND RQLRNVLGGL GNPTDGVIRP DGFDITVASE
210 220 230 240 250
VMAIFCLAKD LADLKTRLGN ILVAYTKDKQ PVYAKDLNAH GAMAALLKDA
260 270 280 290 300
IKPNLVQTIE GSPAFIHGGP FANIAHGCNS VTATRLALHL GDYAVTEAGF
310 320 330 340 350
GADLGAEKFC DIKCRLADLK PDVAVVVATV KALKYNGGVE KANLAEENLT
360 370 380 390 400
ALQQGLPNLL KHISNLKNVF GLPVVVALNR FVSDTDAELA LIQTACAKQG
410 420 430 440 450
VEVSLTEVWG KGGAGGVDLA QKVLKAIDEQ ENRFNFVYDV NESVQNKIKA
460 470 480 490 500
IAQKIYGADD VNFSAEALAE IKNLEKLGLD KLPICMAKTQ YSLSDNAKLL
510 520 530 540 550
GCPSGFTVTV RSISVSAGAG FIVAICGSIM RMPGLPKVPA ANRIDVDENG

LITGLF
Length:556
Mass (Da):58,955
Last modified:April 3, 2007 - v1
Checksum:iAD5278FBF34F08E5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000569 Genomic DNA. Translation: ABN73570.1.
RefSeqiYP_001053175.1. NC_009053.1.

Genome annotation databases

EnsemblBacteriaiABN73570; ABN73570; APL_0466.
GeneIDi4850530.
KEGGiapl:APL_0466.
PATRICi20745760. VBIActPle94089_0482.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000569 Genomic DNA. Translation: ABN73570.1 .
RefSeqi YP_001053175.1. NC_009053.1.

3D structure databases

ProteinModelPortali A3MZI4.
SMRi A3MZI4. Positions 4-554.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 416269.APL_0466.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABN73570 ; ABN73570 ; APL_0466 .
GeneIDi 4850530.
KEGGi apl:APL_0466.
PATRICi 20745760. VBIActPle94089_0482.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi GIEHEAS.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci APLE416269:GHV7-476-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Actinobacillus pleuropneumoniae L20 (serotype 5b)."
    Foote S.J., Bosse J.T., Bouevitch A.B., Langford P.R., Young N.M., Nash J.H.E.
    J. Bacteriol. 190:1495-1496(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: L20.

Entry informationi

Entry nameiFTHS_ACTP2
AccessioniPrimary (citable) accession number: A3MZI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: April 3, 2007
Last modified: October 1, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3