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A3MZI4

- FTHS_ACTP2

UniProt

A3MZI4 - FTHS_ACTP2

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Actinobacillus pleuropneumoniae serotype 5b (strain L20)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi64 – 718ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciAPLE416269:GHV7-476-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:APL_0466
    OrganismiActinobacillus pleuropneumoniae serotype 5b (strain L20)
    Taxonomic identifieri416269 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeActinobacillus
    ProteomesiUP000001432: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 556556Formate--tetrahydrofolate ligasePRO_0000300513Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi416269.APL_0466.

    Structurei

    3D structure databases

    ProteinModelPortaliA3MZI4.
    SMRiA3MZI4. Positions 4-554.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiGIEHEAS.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A3MZI4-1 [UniParc]FASTAAdd to Basket

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    MKSDVEIAQA ATMQPIHKIA EKLGLNADQI EQYGKYKAKI NPTDAFKLPA    50
    KNGKLILVTA INPTPAGEGK TTVTIGLTDA LNQLGKNAVV AAREPSLGPV 100
    FGVKGGAAGG GYAQVLPMED INLHFTGDFH AITSANNLLA ALLDNHIYQG 150
    NALNIDTKRV LWRRVIDMND RQLRNVLGGL GNPTDGVIRP DGFDITVASE 200
    VMAIFCLAKD LADLKTRLGN ILVAYTKDKQ PVYAKDLNAH GAMAALLKDA 250
    IKPNLVQTIE GSPAFIHGGP FANIAHGCNS VTATRLALHL GDYAVTEAGF 300
    GADLGAEKFC DIKCRLADLK PDVAVVVATV KALKYNGGVE KANLAEENLT 350
    ALQQGLPNLL KHISNLKNVF GLPVVVALNR FVSDTDAELA LIQTACAKQG 400
    VEVSLTEVWG KGGAGGVDLA QKVLKAIDEQ ENRFNFVYDV NESVQNKIKA 450
    IAQKIYGADD VNFSAEALAE IKNLEKLGLD KLPICMAKTQ YSLSDNAKLL 500
    GCPSGFTVTV RSISVSAGAG FIVAICGSIM RMPGLPKVPA ANRIDVDENG 550
    LITGLF 556
    Length:556
    Mass (Da):58,955
    Last modified:April 3, 2007 - v1
    Checksum:iAD5278FBF34F08E5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000569 Genomic DNA. Translation: ABN73570.1.
    RefSeqiYP_001053175.1. NC_009053.1.

    Genome annotation databases

    EnsemblBacteriaiABN73570; ABN73570; APL_0466.
    GeneIDi4850530.
    KEGGiapl:APL_0466.
    PATRICi20745760. VBIActPle94089_0482.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000569 Genomic DNA. Translation: ABN73570.1 .
    RefSeqi YP_001053175.1. NC_009053.1.

    3D structure databases

    ProteinModelPortali A3MZI4.
    SMRi A3MZI4. Positions 4-554.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 416269.APL_0466.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABN73570 ; ABN73570 ; APL_0466 .
    GeneIDi 4850530.
    KEGGi apl:APL_0466.
    PATRICi 20745760. VBIActPle94089_0482.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi GIEHEAS.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci APLE416269:GHV7-476-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Actinobacillus pleuropneumoniae L20 (serotype 5b)."
      Foote S.J., Bosse J.T., Bouevitch A.B., Langford P.R., Young N.M., Nash J.H.E.
      J. Bacteriol. 190:1495-1496(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: L20.

    Entry informationi

    Entry nameiFTHS_ACTP2
    AccessioniPrimary (citable) accession number: A3MZI4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3