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Reviewed, UniProtKB/Swiss-Prot A3MZC4 (DXR_ACTP2)

Last modified November 3, 2009. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    1-deoxy-D-xylulose 5-phosphate reductoisomerase
      Short name=DXP reductoisomerase
    EC=1.1.1.267
Alternative name(s):
    1-deoxyxylulose-5-phosphate reductoisomerase
    2-C-methyl-D-erythritol 4-phosphate synthase
Gene names
Name: dxr
Ordered Locus Names: APL_0406
OrganismActinobacillus pleuropneumoniae serotype 5b (strain L20) [Complete proteome] [HAMAP]
Taxonomic identifier416269 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

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Protein attributes

Sequence length396 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity.

Catalytic activity

2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH. HAMAP MF_00183

Cofactor

Divalent cation By similarity.

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6. HAMAP MF_00183

Sequence similarities

Belongs to the DXR family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3963961-deoxy-D-xylulose 5-phosphate reductoisomerase HAMAP MF_00183
PRO_1000020210

Regions

Nucleotide binding7 – 3630NADP By similarity

Sites

Metal binding1501Divalent metal cation By similarity
Metal binding1521Divalent metal cation By similarity
Metal binding2311Divalent metal cation By similarity
Binding site1251Substrate By similarity
Binding site1521Substrate By similarity
Binding site1861Substrate By similarity
Binding site2091Substrate By similarity
Binding site2311Substrate By similarity

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Sequences

Sequence LengthMass (Da)Tools
A3MZC4-1 [UniParc].

Last modified April 3, 2007. Version 1.
Checksum: 9EDED25FB562E95F

FASTA39642,953
        10         20         30         40         50         60 
MKKLVILGST GSIGKSTLSV VEQNKTEYEV FGLVGGKNVE LMAAQCLLFQ PKFAALDDEN 

        70         80         90        100        110        120 
AAKALEEQLR QLNVKTEVLS GQKAICELSA HPEVDMVMAA IVGAAGLLPT LSAVKAGKKV 

       130        140        150        160        170        180 
LLANKESLVT CGQIFIDEAR KSGAQLLPVD SEHNAIFQSL PPDAQQKVGF CPLAELGVSK 

       190        200        210        220        230        240 
IILTGSGGPF RVKPLDEFAA ITPAQAVAHP NWSMGKKISV DSATMMNKGL EYIEARWLFN 

       250        260        270        280        290        300 
ASAEEMEIII HPQSIIHSMV RYIDGSVIAQ MGNPDMCTPI AHTMAYPKRI NAGVAPLDFF 

       310        320        330        340        350        360 
KLKELTFIEP DFARYPNLKL AIDAFAEGQY ATTAMNAANE VAVEAFLNER IRFIDIVNVN 

       370        380        390 
RTVVENIAPV QVKEIADVLH IDKLARELAE QAVINL

« Hide

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References

[1]"The complete genome sequence of Actinobacillus pleuropneumoniae L20 (serotype 5b)."
Foote S.J., Bosse J.T., Bouevitch A.B., Langford P.R., Young N.M., Nash J.H.E.
J. Bacteriol. 190:1495-1496(2008) [PubMed: 18065534] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

CP000569 Genomic DNA. Translation: ABN73510.1.
RefSeqYP_001053115.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA3MZC4.

Genome annotation databases

GeneID4850032.
GenomeReviewsGene locus APL_0406 in contig CP000569_GR.
KEGGapl:APL_0406.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAIHSMVEY.

Family and domain databases

HAMAPMF_00183.
[Tree]
InterProIPR003821. DXP_reductoisomerase.
IPR013644. DXP_reductoisomerase_C.
IPR013512. DXP_reductoisomerase_N.
[Graphical view]
PfamPF08436. DXP_redisom_C. 1 hit.
PF02670. DXP_reductoisom. 1 hit.
[Graphical view]
PIRSFPIRSF006205. Dxp_reductismrs. 1 hit.
TIGRFAMsTIGR00243. Dxr. 1 hit.
ProtoNetSearch...

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Entry information

Entry nameDXR_ACTP2
AccessionPrimary (citable) accession number: A3MZC4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: November 3, 2009
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents