Skip Header

Contribute Send feedback
Read comments (?) or add your own

A3MYR5 (AROB_ACTP2) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:APL_0193
OrganismActinobacillus pleuropneumoniae serotype 5b (strain L20) [Complete proteome] [HAMAP]
Taxonomic identifier416269 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length366 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

Divalent metal cations By similarity. HAMAP MF_00110

NAD By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm By similarity HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3663663-dehydroquinate synthase HAMAP MF_00110
PRO_1000094444

Sequences

Sequence LengthMass (Da)Tools
A3MYR5 [UniParc].

Last modified April 3, 2007. Version 1.
Checksum: F3C60FC8D52DE93A

FASTA36640,043
        10         20         30         40         50         60 
MLQVNVELKE RRYPITIGAG LLGDPNSYSS LKAGDKVMIV SNPTVAAHYL ATVTNTLNGL 

        70         80         90        100        110        120 
GCSVDSVLIP DGEKYKTLDS LNMIFTALLE KNHNRDTTLI ALGGGVIGDV AGYAAASYQR 

       130        140        150        160        170        180 
GIRFIQIPTT LLAQVDSSVG GKTAVNHPLG KNMIGAFYQP ISVIIDTNTL QTLPKREVSA 

       190        200        210        220        230        240 
GLAEVIKYGA IFDIHFFEWL ESNIHHLVAL KQNELEYCIQ RCCQLKADVV ARDETEKGDR 

       250        260        270        280        290        300 
ALLNLGHTFG HAIEAHLGYG NWLHGEAVSV GMLEAAELSR ILGDLSAQDV SRLERLLAQA 

       310        320        330        340        350        360 
VLPTISPDGM EPSEYLPYMW RDKKVLGGQL RLVLLKSLGK AYVTAQASEQ QVLSAIERFT 


QREFHE

« Hide

References

[1]"The complete genome sequence of Actinobacillus pleuropneumoniae L20 (serotype 5b)."
Foote S.J., Bosse J.T., Bouevitch A.B., Langford P.R., Young N.M., Nash J.H.E.
J. Bacteriol. 190:1495-1496(2008) [PubMed: 18065534] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: L20.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000569 Genomic DNA. Translation: ABN73301.1.
RefSeqYP_001052906.1. NC_009053.1.

3D structure databases

ProteinModelPortalA3MYR5.
ModBaseSearch...

Protein-protein interaction databases

STRINGA3MYR5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4849357.
GenomeReviewsGene locus APL_0193 in contig CP000569_GR.
KEGGapl:APL_0193.
PATRIC20745176. VBIActPle94089_0197.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0337.
HOGENOMHBG632303.
OMAVMALEMS.
PhylomeDBA3MYR5.
ProtClustDBPRK00002.

Enzyme and pathway databases

BioCycAPLE416269:APL_0193-MONOMER.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_ACTP2
AccessionPrimary (citable) accession number: A3MYR5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 3, 2007
Last modified: December 14, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents