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A3MYI4 (DCUP_ACTP2) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uroporphyrinogen decarboxylase

Short name=UPD
Short name=URO-D
EC=4.1.1.37
Gene names
Name:hemE
Ordered Locus Names:APL_0112
OrganismActinobacillus pleuropneumoniae serotype 5b (strain L20) [Complete proteome] [HAMAP]
Taxonomic identifier416269 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeActinobacillus

Protein attributes

Sequence length354 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP-Rule MF_00218

Catalytic activity

Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP-Rule MF_00218

Pathway

Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP-Rule MF_00218

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00218

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00218.

Sequence similarities

Belongs to the uroporphyrinogen decarboxylase family.

Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Cellular componentCytoplasm
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processprotoporphyrinogen IX biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionuroporphyrinogen decarboxylase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 354354Uroporphyrinogen decarboxylase HAMAP-Rule MF_00218
PRO_1000023867

Regions

Region27 – 315Substrate binding By similarity

Sites

Binding site771Substrate By similarity
Binding site1541Substrate By similarity
Binding site2091Substrate By similarity
Binding site3271Substrate By similarity
Site771Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
A3MYI4 [UniParc].

Last modified April 3, 2007. Version 1.
Checksum: DD57D5BF88FF587C

FASTA35439,360
        10         20         30         40         50         60 
MNQLKNDRYL KALLREPVDM TPVWMMRQAG RYLPEYKATR AEAGDFMALC RNADLACEVT 

        70         80         90        100        110        120 
LQPLRRYALD AAILFSDILT VPDAMGLGLS FGAGEGPKFA RPIENKAQVD NLPIPDPESE 

       130        140        150        160        170        180 
LQYVMNAVRT IRRELKGEVP LIGFSGSPWT LATYMVEGGS SKAFTKIKKM MYADPKILHA 

       190        200        210        220        230        240 
LLDKLADSVI LYLNAQIKAG AQAVMVFDTW GGVLAHNEYK EFSLRYMHKI VDGLIRENEG 

       250        260        270        280        290        300 
RKVPVTLFTK GGGLWLEAIA ETGCDAVGLD WTVDIADARR RVGHKVALQG NMDPSVLYAQ 

       310        320        330        340        350 
PERIELEVKQ ILAGFGQGSG HVFNLGHGIH QDVPEQSPKV FVDAVHEYSK QYHK 

« Hide

References

[1]"The complete genome sequence of Actinobacillus pleuropneumoniae L20 (serotype 5b)."
Foote S.J., Bosse J.T., Bouevitch A.B., Langford P.R., Young N.M., Nash J.H.E.
J. Bacteriol. 190:1495-1496(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: L20.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000569 Genomic DNA. Translation: ABN73220.1.
RefSeqYP_001052825.1. NC_009053.1.

3D structure databases

ProteinModelPortalA3MYI4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING416269.APL_0112.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABN73220; ABN73220; APL_0112.
GeneID4849940.
KEGGapl:APL_0112.
PATRIC20745014. VBIActPle94089_0116.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0407.
HOGENOMHOG000253896.
KOK01599.
OMATLATYMI.
OrthoDBEOG6VXF6H.
ProtClustDBPRK00115.

Enzyme and pathway databases

BioCycAPLE416269:GHV7-117-MONOMER.
UniPathwayUPA00251; UER00321.

Family and domain databases

HAMAPMF_00218. URO_D.
InterProIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
PANTHERPTHR21091:SF2. PTHR21091:SF2. 1 hit.
PfamPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsTIGR01464. hemE. 1 hit.
PROSITEPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDCUP_ACTP2
AccessionPrimary (citable) accession number: A3MYI4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: February 19, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways