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Reviewed, UniProtKB/Swiss-Prot A3MYI4 (DCUP_ACTP2)

Last modified November 3, 2009. Version 19. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Uroporphyrinogen decarboxylase
      Short name=URO-D
      Short name=UPD
    EC=4.1.1.37
Gene names
Name: hemE
Ordered Locus Names: APL_0112
OrganismActinobacillus pleuropneumoniae serotype 5b (strain L20) [Complete proteome] [HAMAP]
Taxonomic identifier416269 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

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Protein attributes

Sequence length354 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity.

Catalytic activity

Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the uroporphyrinogen decarboxylase family.

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Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Cellular componentCytoplasm
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processporphyrin biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionuroporphyrinogen decarboxylase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 354354Uroporphyrinogen decarboxylase HAMAP MF_00218
PRO_1000023867

Regions

Region27 – 315Substrate binding By similarity

Sites

Binding site771Substrate By similarity
Binding site1541Substrate By similarity
Binding site2091Substrate By similarity
Binding site3271Substrate By similarity
Site771Transition state stabilizer By similarity

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Sequences

Sequence LengthMass (Da)Tools
A3MYI4-1 [UniParc].

Last modified April 3, 2007. Version 1.
Checksum: DD57D5BF88FF587C

FASTA35439,360
        10         20         30         40         50         60 
MNQLKNDRYL KALLREPVDM TPVWMMRQAG RYLPEYKATR AEAGDFMALC RNADLACEVT 

        70         80         90        100        110        120 
LQPLRRYALD AAILFSDILT VPDAMGLGLS FGAGEGPKFA RPIENKAQVD NLPIPDPESE 

       130        140        150        160        170        180 
LQYVMNAVRT IRRELKGEVP LIGFSGSPWT LATYMVEGGS SKAFTKIKKM MYADPKILHA 

       190        200        210        220        230        240 
LLDKLADSVI LYLNAQIKAG AQAVMVFDTW GGVLAHNEYK EFSLRYMHKI VDGLIRENEG 

       250        260        270        280        290        300 
RKVPVTLFTK GGGLWLEAIA ETGCDAVGLD WTVDIADARR RVGHKVALQG NMDPSVLYAQ 

       310        320        330        340        350 
PERIELEVKQ ILAGFGQGSG HVFNLGHGIH QDVPEQSPKV FVDAVHEYSK QYHK

« Hide

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References

[1]"The complete genome sequence of Actinobacillus pleuropneumoniae L20 (serotype 5b)."
Foote S.J., Bosse J.T., Bouevitch A.B., Langford P.R., Young N.M., Nash J.H.E.
J. Bacteriol. 190:1495-1496(2008) [PubMed: 18065534] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

CP000569 Genomic DNA. Translation: ABN73220.1.
RefSeqYP_001052825.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA3MYI4.

Genome annotation databases

GeneID4849940.
GenomeReviewsGene locus APL_0112 in contig CP000569_GR.
KEGGapl:APL_0112.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAVFTKGGG.

Family and domain databases

HAMAPMF_00218.
[Tree]
InterProIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
PANTHERPTHR21091:SF2. HemE. 1 hit.
PfamPF01208. URO-D. 1 hit.
[Graphical view]
ProDomPD003225. Uro_decarbxyls. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR01464. hemE. 1 hit.
PROSITEPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameDCUP_ACTP2
AccessionPrimary (citable) accession number: A3MYI4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: November 3, 2009
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents