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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Pyrobaculum calidifontis (strain JCM 11548 / VA1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:Pcal_1822
OrganismiPyrobaculum calidifontis (strain JCM 11548 / VA1)
Taxonomic identifieri410359 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
Proteomesi
  • UP000001431 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000189971 – 374Tryptophan--tRNA ligaseAdd BLAST374

Proteomic databases

PRIDEiA3MX72

Interactioni

Protein-protein interaction databases

STRINGi410359.Pcal_1822

Structurei

3D structure databases

ProteinModelPortaliA3MX72
SMRiA3MX72
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi81 – 89"HIGH" region9
Motifi258 – 262"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01887 Archaea
COG0180 LUCA
HOGENOMiHOG000224742
KOiK01867
OMAiADILHPQ
OrthoDBiPOG093Z034D

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00140_A Trp_tRNA_synth_A, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR020653 Tryptophan-tRNA-ligase_arc
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A3MX72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEEFVVTPW EVRGRVDYQK LMQQFGARPL TQAEVSLLEK YAGEVHPLIR
60 70 80 90 100
RGFFYAHRDL DAILKWHGEG KPWALYTGRG PSGPVHIGHM VPWILLKWLS
110 120 130 140 150
DKFGVEVYFQ MTDDEKFYDD PEMRLEEATK WAYENALDVI ALGFTPDKLH
160 170 180 190 200
LIIDTKDIKP LYPIAAKVAK KLTWNTVKAT FGFTDSTNIG LIFYPSLQIA
210 220 230 240 250
VAFLPTELHG RPTPVLIPCA IDQDPYFRLA RDIAESLGYP KPATLYSKFI
260 270 280 290 300
MALTGESKMS ASNPNSAIYT IDDEKTIRRK IANAYTGGRP TAEEQRRLGG
310 320 330 340 350
NPDVCPVYHY HMLFDPDDAS VEKIYHSCKS GALLCGECKQ MLYEKIRKFV
360 370
KQHQEAREKA RDKVDAYRLS SKLS
Length:374
Mass (Da):42,675
Last modified:April 3, 2007 - v1
Checksum:i23BE96FD004632BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000561 Genomic DNA Translation: ABO09239.1

Genome annotation databases

EnsemblBacteriaiABO09239; ABO09239; Pcal_1822
KEGGipcl:Pcal_1822

Similar proteinsi

Entry informationi

Entry nameiSYW_PYRCJ
AccessioniPrimary (citable) accession number: A3MX72
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: May 23, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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