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A3MX72

- SYW_PYRCJ

UniProt

A3MX72 - SYW_PYRCJ

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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Pyrobaculum calidifontis (strain JCM 11548 / VA1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPCAL410359:GIX2-1865-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:Pcal_1822
OrganismiPyrobaculum calidifontis (strain JCM 11548 / VA1)
Taxonomic identifieri410359 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
ProteomesiUP000001431: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 374374Tryptophan--tRNA ligasePRO_1000018997Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi410359.Pcal_1822.

Structurei

3D structure databases

ProteinModelPortaliA3MX72.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi81 – 899"HIGH" region
Motifi258 – 2625"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0180.
HOGENOMiHOG000224742.
KOiK01867.
OMAiEFVVTPW.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00140_A. Trp_tRNA_synth_A.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR020653. Tryptophan-tRNA-ligase_arc.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.
TIGRFAMsiTIGR00233. trpS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3MX72-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDEEFVVTPW EVRGRVDYQK LMQQFGARPL TQAEVSLLEK YAGEVHPLIR
60 70 80 90 100
RGFFYAHRDL DAILKWHGEG KPWALYTGRG PSGPVHIGHM VPWILLKWLS
110 120 130 140 150
DKFGVEVYFQ MTDDEKFYDD PEMRLEEATK WAYENALDVI ALGFTPDKLH
160 170 180 190 200
LIIDTKDIKP LYPIAAKVAK KLTWNTVKAT FGFTDSTNIG LIFYPSLQIA
210 220 230 240 250
VAFLPTELHG RPTPVLIPCA IDQDPYFRLA RDIAESLGYP KPATLYSKFI
260 270 280 290 300
MALTGESKMS ASNPNSAIYT IDDEKTIRRK IANAYTGGRP TAEEQRRLGG
310 320 330 340 350
NPDVCPVYHY HMLFDPDDAS VEKIYHSCKS GALLCGECKQ MLYEKIRKFV
360 370
KQHQEAREKA RDKVDAYRLS SKLS
Length:374
Mass (Da):42,675
Last modified:April 3, 2007 - v1
Checksum:i23BE96FD004632BA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000561 Genomic DNA. Translation: ABO09239.1.
RefSeqiWP_011850497.1. NC_009073.1.
YP_001056705.1. NC_009073.1.

Genome annotation databases

EnsemblBacteriaiABO09239; ABO09239; Pcal_1822.
GeneIDi4909500.
KEGGipcl:Pcal_1822.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000561 Genomic DNA. Translation: ABO09239.1 .
RefSeqi WP_011850497.1. NC_009073.1.
YP_001056705.1. NC_009073.1.

3D structure databases

ProteinModelPortali A3MX72.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 410359.Pcal_1822.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABO09239 ; ABO09239 ; Pcal_1822 .
GeneIDi 4909500.
KEGGi pcl:Pcal_1822.

Phylogenomic databases

eggNOGi COG0180.
HOGENOMi HOG000224742.
KOi K01867.
OMAi EFVVTPW.

Enzyme and pathway databases

BioCyci PCAL410359:GIX2-1865-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00140_A. Trp_tRNA_synth_A.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR020653. Tryptophan-tRNA-ligase_arc.
[Graphical view ]
PANTHERi PTHR10055. PTHR10055. 1 hit.
Pfami PF00579. tRNA-synt_1b. 1 hit.
[Graphical view ]
PRINTSi PR01039. TRNASYNTHTRP.
TIGRFAMsi TIGR00233. trpS. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCM 11548 / VA1.

Entry informationi

Entry nameiSYW_PYRCJ
AccessioniPrimary (citable) accession number: A3MX72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: October 29, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3