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Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Pyrobaculum calidifontis (strain JCM 11548 / VA1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamyl-tRNA reductase 2 (hemA2), Glutamyl-tRNA reductase 1 (hemA1)
  2. Glutamate-1-semialdehyde 2,1-aminomutase (hemL)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu), the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processPorphyrin biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00251; UER00317

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
Short name:
GSAUniRule annotation
Alternative name(s):
Glutamate-1-semialdehyde aminotransferaseUniRule annotation
Short name:
GSA-ATUniRule annotation
Gene namesi
Name:hemLUniRule annotation
Ordered Locus Names:Pcal_1717
OrganismiPyrobaculum calidifontis (strain JCM 11548 / VA1)
Taxonomic identifieri410359 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
Proteomesi
  • UP000001431 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000599991 – 441Glutamate-1-semialdehyde 2,1-aminomutaseAdd BLAST441

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei273N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiA3MWW7

Interactioni

Protein-protein interaction databases

STRINGi410359.Pcal_1717

Structurei

3D structure databases

ProteinModelPortaliA3MWW7
SMRiA3MWW7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00918 Archaea
COG0001 LUCA
HOGENOMiHOG000020210
KOiK01845
OMAiWGPLIFG
OrthoDBiPOG093Z024H

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00375 HemL_aminotrans_3, 1 hit
InterProiView protein in InterPro
IPR004639 4pyrrol_synth_GluAld_NH2Trfase
IPR005814 Aminotrans_3
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR00713 hemL, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit

Sequencei

Sequence statusi: Complete.

A3MWW7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFDVQFLKV FDGVLMLFER AKAVFPGGVN SPARALKHLP TPLVAKAASG
60 70 80 90 100
PYLYTDRGRL VDFCLAFGAI ILGHAHPKVR RAVEEQLARG WIYALLTEEE
110 120 130 140 150
VLFAEKIRAH VPSVEKMRFV NSGTEATMNA VRLARGFTGR DYIIKFDGNF
160 170 180 190 200
HGSHDYVLVK AGSGAATWGI PTSAGIPSDV VKMTVVVPYN DVDAFVKAVR
210 220 230 240 250
EVGDRLAAVI VEPIAGNYGL ILPEVEFLKA LREETERVGA LLIFDEVITG
260 270 280 290 300
FRVGLGGAQG LYGVVPDLTT LGKVIGGGFP IGVFGGKSFI MDLVAPQGPV
310 320 330 340 350
YNAGTFNAHP VSIAAGLAVL EELEGGQVYS VANDAARRMA EGIRDLAERV
360 370 380 390 400
GFDVVVKHIA SMFQFYFKKG DVKTPQDVRE SNEKLYLKLH ELAIGHGVYL
410 420 430 440
APSQFEVNFT SAAHTAEVVE EALGALEKVF RELRREVGGN S
Length:441
Mass (Da):47,718
Last modified:April 3, 2007 - v1
Checksum:i4378A5746A3C2705
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000561 Genomic DNA Translation: ABO09134.1

Genome annotation databases

EnsemblBacteriaiABO09134; ABO09134; Pcal_1717
KEGGipcl:Pcal_1717

Similar proteinsi

Entry informationi

Entry nameiGSA_PYRCJ
AccessioniPrimary (citable) accession number: A3MWW7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: April 3, 2007
Last modified: May 23, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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