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A3MWW7

- GSA_PYRCJ

UniProt

A3MWW7 - GSA_PYRCJ

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Protein
Glutamate-1-semialdehyde 2,1-aminomutase
Gene
hemL, Pcal_1717
Organism
Pyrobaculum calidifontis (strain JCM 11548 / VA1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciPCAL410359:GIX2-1753-MONOMER.
UniPathwayiUPA00251; UER00317.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase (EC:5.4.3.8)
Short name:
GSA
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name:
GSA-AT
Gene namesi
Name:hemL
Ordered Locus Names:Pcal_1717
OrganismiPyrobaculum calidifontis (strain JCM 11548 / VA1)
Taxonomic identifieri410359 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
ProteomesiUP000001431: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 441441Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation
PRO_1000059999Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei273 – 2731N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Protein-protein interaction databases

STRINGi410359.Pcal_1717.

Structurei

3D structure databases

ProteinModelPortaliA3MWW7.
SMRiA3MWW7. Positions 15-434.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0001.
HOGENOMiHOG000020210.
KOiK01845.
OMAiRAIKPYP.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A3MWW7-1 [UniParc]FASTAAdd to Basket

« Hide

MPFDVQFLKV FDGVLMLFER AKAVFPGGVN SPARALKHLP TPLVAKAASG    50
PYLYTDRGRL VDFCLAFGAI ILGHAHPKVR RAVEEQLARG WIYALLTEEE 100
VLFAEKIRAH VPSVEKMRFV NSGTEATMNA VRLARGFTGR DYIIKFDGNF 150
HGSHDYVLVK AGSGAATWGI PTSAGIPSDV VKMTVVVPYN DVDAFVKAVR 200
EVGDRLAAVI VEPIAGNYGL ILPEVEFLKA LREETERVGA LLIFDEVITG 250
FRVGLGGAQG LYGVVPDLTT LGKVIGGGFP IGVFGGKSFI MDLVAPQGPV 300
YNAGTFNAHP VSIAAGLAVL EELEGGQVYS VANDAARRMA EGIRDLAERV 350
GFDVVVKHIA SMFQFYFKKG DVKTPQDVRE SNEKLYLKLH ELAIGHGVYL 400
APSQFEVNFT SAAHTAEVVE EALGALEKVF RELRREVGGN S 441
Length:441
Mass (Da):47,718
Last modified:April 3, 2007 - v1
Checksum:i4378A5746A3C2705
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000561 Genomic DNA. Translation: ABO09134.1.
RefSeqiWP_011850393.1. NC_009073.1.
YP_001056600.1. NC_009073.1.

Genome annotation databases

EnsemblBacteriaiABO09134; ABO09134; Pcal_1717.
GeneIDi4908200.
KEGGipcl:Pcal_1717.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000561 Genomic DNA. Translation: ABO09134.1 .
RefSeqi WP_011850393.1. NC_009073.1.
YP_001056600.1. NC_009073.1.

3D structure databases

ProteinModelPortali A3MWW7.
SMRi A3MWW7. Positions 15-434.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 410359.Pcal_1717.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABO09134 ; ABO09134 ; Pcal_1717 .
GeneIDi 4908200.
KEGGi pcl:Pcal_1717.

Phylogenomic databases

eggNOGi COG0001.
HOGENOMi HOG000020210.
KOi K01845.
OMAi RAIKPYP.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .
BioCyci PCAL410359:GIX2-1753-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCM 11548 / VA1.

Entry informationi

Entry nameiGSA_PYRCJ
AccessioniPrimary (citable) accession number: A3MWW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: April 3, 2007
Last modified: September 3, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3